CAS Number54-31-9
SynonymsMirfat; furesis; Odemase; Frumex; furosedon; Durafurid; Furosemide,5-(Aminosulfonyl)-4-chloro-2-([2-furanylmethyl]amino)benzoicacid; Frusemide; frusid; dryptal; Frusetic; Errolon; trofurit; Nicorol; EINECS 200-203-6; Urex; macasirool; lasilix; Furosemid; Oedemex; Discoid; katlex; Impugan; profemin; desdemin; Furosemide; Fusid; 4-Chloro-2-[(2-furylmethyl)amino]-5-sulfamoylbenzoic acid; Lasix; Eutensin
Molecular FormulaC12H11ClN2O5S
Molecular Weight330.74
Purity99%
Density1.6±0.1 g/cm3
Boiling Point582.1±60.0 °C at 760 mmHg
Melting Point220 °C (dec.)(lit.)
Appearanceliquid
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 54-31-9 |
| Catalog No. | 2A-9010663 |
| Chinese Name | 呋噻米 |
| Synonyms | Mirfat; furesis; Odemase; Frumex; furosedon; Durafurid; Furosemide,5-(Aminosulfonyl)-4-chloro-2-([2-furanylmethyl]amino)benzoicacid; Frusemide; frusid; dryptal; Frusetic; Errolon; trofurit; Nicorol; EINECS 200-203-6; Urex; macasirool; lasilix; Furosemid; Oedemex; Discoid; katlex; Impugan; profemin; desdemin; Furosemide; Fusid; 4-Chloro-2-[(2-furylmethyl)amino]-5-sulfamoylbenzoic acid; Lasix; Eutensin |
| Molecular Formula | C12H11ClN2O5S |
| Molecular Weight | 330.74 |
| Purity | 99 |
| Density | 1.6±0.1 g/cm3 |
| Boiling Point | 582.1±60.0 °C at 760 mmHg |
| Melting Point | 220 °C (dec.)(lit.) |
| Appearance | liquid |
| Storage Condition | This product should be sealed and stored in a cool |
| Application | Furosemide (Lasix) is an inhibitor of the Na+/2Cl-/K+ (NKCC) co-transport channel. |
| HTC | 2942000000 |
| MDL Number | MFCD00010549 |
| SMILES | NS(=O)(=O)c1cc(C(O)=O)c(NCc2ccco2)cc1Cl |
| InChI | 1S/C12H11ClN2O5S/c13-9-5-10(15-6-7-2-1-3-20-7)8(12(16)17)4-11(9)21(14,18)19/h1-5,15H,6H2,(H,16,17)(H2,14,18,19) |
| InChI Key | ZZUFCTLCJUWOSV-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | Transport |
| MSDS | msds/10663_1_54_31_9.pdf |
| Bioactivity | Furosemide (Lasix) is a loop diuretic inhibitor of Na+/2Cl-/K+ (NKCC) cotransporter of which used in the treatment of congestive heart failure and edema.Target: NKCC Furosemide (INN/BAN) or frusemide is a loop diuretic used in the treatment of congestive heart failure and edema. It is most commonly marketed by Sanofi under the brand name Lasix, and also under the brand names Fusid and Frumex. It has also been used to prevent Thoroughbred and Standardbred race horses from bleeding through the nose during races.Along with some other diuretics, furosemide is also included on the World Anti-Doping Agency's banned drug list due to its alleged use as a masking agent for other drugs.Furosemide, like other loop diuretics, acts by inhibiting NKCC2, the luminal Na-K-2Cl symporter in the thick ascending limb of the loop of Henle. The action on the distal tubules is independent of any inhibitory effect on carbonic anhydrase or aldosterone; it also abolishes the corticomedullary osmotic gradient and blocks negative, as well as positive, free water clearance.Because of the large NaCl absorptive capacity of the loop of Henle, diuresis is not limited by development of acidosis, as it is with the carbonic anhydrase inhibitors. Additionally, furosemide is a noncompetitive subtype-specific blocker of GABA-A receptors. Furosemide has been reported to reversibly antagonize GABA-evoked currents of α6β2γ2 receptors at uM concentrations, but not α1β2γ2 receptors. During development, the α6β2γ2 receptor increases in expression in cerebellar granule neurons, corresponding to increased sensitivity to furosemide Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> NKCC Research Areas >> Metabolic Disease References [1]. Rais-Bahrami K, et al. Use of furosemide and hearing loss in neonatal intensive care survivors. Am J Perinatol. 2004 Aug;21(6):329-32. [2]. Tia S, et al. Developmental changes of inhibitory synaptic currents in cerebellar granule neurons: role of GABA (A) receptor alpha 6 subunit. J Neurosci. 1996 Jun 1;16(11):3630-40. [3]. Korpi ER, et al. Selective antagonist for the cerebellar granule cell-specific gamma-aminobutyric acid type A receptor. Mol Pharmacol.1995 Feb;47(2):283-9. Chemical & Physical Properties Density 1.6±0.1 g/cm3 Boiling Point 582.1±60.0 °C at 760 mmHg Melting Point 220 °C (dec.)(lit.) Molecular Formula C12H11ClN2O5S Molecular Weight 330.744 Flash Point 305.9±32.9 °C Exact Mass 330.007721 PSA 131.01000 LogP 3.10 Vapour Pressure 0.0±1.7 mmHg at 25°C Index of Refraction 1.658 InChIKey ZZUFCTLCJUWOSV-UHFFFAOYSA-N SMILES NS(=O)(=O)c1cc(C(=O)O)c(NCc2ccco2)cc1Cl Stability Stable, but light sensitive, air sensitive and hygroscopic. Incompatible with strong oxidizing agents. |
| Use of | Properties Articles188 Name furosemide Synonym More Synonyms Furosemide Biological Activity Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> NKCC Research Areas >> Metabolic Disease References [1]. Rais-Bahrami K, et al. Use of furosemide and hearing loss in neonatal intensive care survivors. Am J Perinatol. 2004 Aug;21(6):329-32. [2]. Tia S, et al. Developmental changes of inhibitory synaptic currents in cerebellar granule neurons: role of GABA (A) receptor alpha 6 subunit. J Neurosci. 1996 Jun 1;16(11):3630-40. [3]. Korpi ER, et al. Selective antagonist for the cerebellar granule cell-specific gamma-aminobutyric acid type A receptor. Mol Pharmacol.1995 Feb;47(2):283-9. Chemical & Physical Properties Exact Mass 330.007721 PSA 131.01000 Index of Refraction 1.658 InChIKey ZZUFCTLCJUWOSV-UHFFFAOYSA-N Stability Stable, but light sensitive, air sensitive and hygroscopic. Incompatible with strong oxidizing agents. |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 35.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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