CAS Number92134-98-0
SynonymsPro-Epanutin; ACC 9653-010; ACC 9653; Fosphenytoin disodium salt; CI 982; Cerebyx; Fosphenytoin sodium; Fosphenytoin (disodium)
Molecular FormulaC16H13N2Na2O6P
Molecular Weight406.24
Purity98%
Melting Point220ºC
AppearanceWhite crystalline powder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 92134-98-0 |
| Catalog No. | 2A-9010622 |
| Chinese Name | 磷苯妥英钠 |
| Synonyms | Pro-Epanutin; ACC 9653-010; ACC 9653; Fosphenytoin disodium salt; CI 982; Cerebyx; Fosphenytoin sodium; Fosphenytoin (disodium) |
| Molecular Formula | C16H13N2Na2O6P |
| Molecular Weight | 406.24 |
| Purity | 98 |
| Melting Point | 220ºC |
| Appearance | White crystalline powder |
| Water Solubility | H2O: ≥15mg/mL |
| Storage Condition | 2-8°C |
| Application | Fosphenytoin sodium is the precursor drug of phenytoin and has anticonvulsant and other effects. |
| HTC | 2933790090 |
| MDL Number | MFCD00948765 |
| SMILES | [Na+].[Na+].[P](=O)([O-])([O-])OCN1C(=O)NC(C1=O)(c3ccccc3)c2ccccc2 |
| InChI | 1S/C16H15N2O6P.2Na/c19-14-16(12-7-3-1-4-8-12,13-9-5-2-6-10-13)17-15(20)18(14)11-24-25(21,22)23;;/h1-10H,11H2,(H,17,20)(H2,21,22,23);;/q;2*+1/p-2 |
| InChI Key | GQPXYJNXTAFDLT-UHFFFAOYSA-L |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | Transport |
| MSDS | msds/10622_1_92134_98_0.pdf |
| Bioactivity | Fosphenytoin sodium is a phenytoin prodrug with similar anticonvulsant properties. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease In Vivo Fosphenytoin is an effective neuroprotectant against ischemia-induced damage. In fosphenytoin (30 mg/kg, i.m.)-treated rat 5 min after ischemia episode, hippocampal CA1 pyramidal neurons remain at near control level (13.90 ± 0.92), however, GFAP staining iss not significantly changed[1]. In fosphenytoin (84 mg/kg)-treated rat, the relative bioavailability of fosphenytoin is 83%. In fully kindled female Wistar rats, fosphenytoin dose-dependently increases the focal seizure (afterdischarge) threshold. Seizure severity and duration at threshold are reduced only after the highest does of fosphenytoin tested (84 mg/kg)[2]. Animal Admin A total of four groups of rats, including normal (n=2), sham operated (n=2), ischemia with saline-treated (n=2), and ischemia with fosphenytoin-treated (n=2), are studied. Postischemic rats in saline-treated and fosphenytoin-treated groups receive a single i.m. injection of saline or fosphenytoin (30 mg/kg), respectively, in the right hind limb 5 minutes after resuscitation. Sham-operated animals are treated similarly except for chest compression. All rats are killed on the 7th postischemic day by decapitation. Brains are immediately removed, bisected longitudinally, and immersed in 4% buffered neutral formaldehyde containing 0.25% glutaraldehyde for a minimum of 2 days at 4°C. Portions of the brain containing the dorsal hippocampus are coronally sectioned with a vibratome at 40 μm. With the aid of a dissecting microscope, rectangular blocks of about 1 mm2 in size encompassing the mid-CA1 region from sections that approximate Bregma -3.6 are dissected, postfixed in 2% osmium tetroxide, and dehydrated in ascending concentrations of ethanol before being embedded in Araldite 502. Sections of polymerized blocks 1 μm thick are cut and toluidine blue stained for light microscopic examination. References [1]. Chan SA, et al. Fosphenytoin reduces hippocampal neuronal damage in rat following transient global ischemia. Acta Neurochir (Wien). 1998;140(2):175-80. [2]. Loscher W, et al. Anticonvulsant effect of fosphenytoin in amygdala-kindled rats: comparison with phenytoin. Epilepsy Res. 1998 Mar;30(1):69-76. Chemical & Physical Properties Melting Point 220ºC Molecular Formula C16H13N2Na2O6P Molecular Weight 406.23800 Exact Mass 406.03100 PSA 131.64000 LogP 2.69190 InChIKey GQPXYJNXTAFDLT-UHFFFAOYSA-L SMILES O=C1NC(c2ccccc2)(c2ccccc2)C(=O)N1COP(=O)([O-])[O-].[Na+].[Na+] Storage condition 2-8°C Water Solubility H2O: ≥15mg/mL |
| Use of | Fosphenytoin sodium is a phenytoin prodrug with similar anticonvulsant properties. Properties Name disodium,(2,5-dioxo-4,4-diphenylimidazolidin-1-yl)methyl phosphate Synonym More Synonyms Fosphenytoin (disodium) Biological Activity Description Fosphenytoin sodium is a phenytoin prodrug with similar anticonvulsant properties. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease References [1]. Chan SA, et al. Fosphenytoin reduces hippocampal neuronal damage in rat following transient global ischemia. Acta Neurochir (Wien). 1998;140(2):175-80. [2]. Loscher W, et al. Anticonvulsant effect of fosphenytoin in amygdala-kindled rats: comparison with phenytoin. Epilepsy Res. 1998 Mar;30(1):69-76. Chemical & Physical Properties Molecular Formula C16H13N2Na2O6P Exact Mass 406.03100 PSA 131.64000 LogP 2.69190 InChIKey GQPXYJNXTAFDLT-UHFFFAOYSA-L |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 9.0% Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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