| Chemical & Physical Properties | |
|---|---|
| CAS Number | 98048-97-6 |
| Catalog No. | 2A-9010617 |
| Chinese Name | 福辛普利 |
| Synonyms | fosenopril; Staril; Fosinopril; MFCD00870759; Secorvas |
| Molecular Formula | C30H46NO7P |
| Molecular Weight | 585.64 |
| Purity | ≥98 (HPLC) |
| Density | 1.173 g/cm3 |
| Boiling Point | 705.7ºC at 760 mmHg |
| Melting Point | 149-153ºC |
| Appearance | powder |
| Water Solubility | Insoluble |
| Storage Condition | Room Temperature |
| Application | Fosinopril (SQ28555) is an ester prodrug of an angiotensin-converting enzyme (ACE) inhibitor with an IC50 value of 0.18 μM [1]. Fosinopril has a non-competitive inhibitory effect on ACE activity, with |
| HTC | 2942000000 |
| PubChem ID | 329799677 |
| MDL Number | MFCD23704184 |
| SMILES | O=C([O-])[C@H]1N(C(CP(CCCCC2=CC=CC=C2)(O[C@@H](C(C)C)OC(CC)=O)=O)=O)C[C@H](C3CCCCC3)C1.[Na+] |
| InChI | 1S/C30H46NO7P.Na/c1-4-28(33)37-30(22(2)3)38-39(36,18-12-11-15-23-13-7-5-8-14-23)21-27(32)31-20-25(19-26(31)29(34)35)24-16-9-6-10-17-24;/h5,7-8,13-14,22,24-26,30H,4,6,9-12,15-21H2,1-3H3,(H,34,35);/q;+1/p-1/t25-,26+,30+,39?;/m1./s1 |
| InChI Key | TVTJZMHAIQQZTL-TXDYNIFHSA-M |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| MSDS | msds/10617_1_98048_97_6.pdf |
| Use of | Fosinopril (SQ28555) is the ester prodrug of an angiotensin-converting enzyme (ACE) inhibitor with the IC50 value of 0.18 μM[1]. Fosinopril demonstrates a non-competitive inhibition effect on ACE activity with a Ki value of 1.675 μM[2]. Properties Name fosinopril Synonym More Synonyms Fosinopril Biological Activity Description Fosinopril (SQ28555) is the ester prodrug of an angiotensin-converting enzyme (ACE) inhibitor with the IC50 value of 0.18 μM[1]. Fosinopril demonstrates a non-competitive inhibition effect on ACE activity with a Ki value of 1.675 μM[2]. Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE) IC50: 0.18 μM; Ki: 1.675 μM References [1]. Ondetti, M.A., Structural relationships of angiotensin converting-enzyme inhibitors to pharmacologic activity. Circulation, 1988. 77(6 Pt 2): p. I74-8. [2]. Piepho, R.W., Overview of the angiotensin-converting-enzyme inhibitors. Am J Health Syst Pharm, 2000. 57 Suppl 1: p. S3-7. [3]. Sharma, S., et al., The hemodynamic effects of long-term ACE inhibition with fosinopril in patients with heart failure. Fosinopril Hemodynamics Study Group. Am J Ther, 1999. 6(4): p. 181-9. Chemical & Physical Properties Molecular Formula C30H46NO7P Exact Mass 563.30100 PSA 120.02000 LogP 6.05920 Index of Refraction 1.531 InChIKey BIDNLKIUORFRQP-AJTMIRJTSA-N Water Solubility Insoluble Safety Information HS Code 2942000000 |
| Transport Info | Product Name: Fosinopril |
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