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Clarithromycin structure, CAS 81103-11-9

Clarithromycin

CAS Number81103-11-9

SynonymsResclar; Clarithromycin; TE-031; Infex; te-03; Claris; 6-O-Methylerythromycin; Kladd; Clarosip; Veclam; BIAXIN; Claric; Macladin; Klacid; UNII-H1250JIK0A; Cyllind; Vikrol; Naxy; Clacid; Clarihexal; Mavid; Zeclar; Fromilid; Clacee

Molecular FormulaC38H69NO13

Molecular Weight747.95

Purity99%

Density1.2±0.1 g/cm3

Boiling Point805.5±65.0 °C at 760 mmHg

Melting Point217-220ºC

Flash Point

AppearanceWhite to off-white crystalline powder

EINECS

MSDSChineseEnglish

SymbolTransport

Signal WordWarning

Cat. No.: 2A-9009826 Purity: 99%
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Quality Control of [ 81103-11-9 ] Purity: 99% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number81103-11-9
Catalog No.2A-9009826
Chinese Name克拉霉素
SynonymsResclar; Clarithromycin; TE-031; Infex; te-03; Claris; 6-O-Methylerythromycin; Kladd; Clarosip; Veclam; BIAXIN; Claric; Macladin; Klacid; UNII-H1250JIK0A; Cyllind; Vikrol; Naxy; Clacid; Clarihexal; Mavid; Zeclar; Fromilid; Clacee
Molecular FormulaC38H69NO13
Molecular Weight747.95
Purity99
Density1.2±0.1 g/cm3
Boiling Point805.5±65.0 °C at 760 mmHg
Melting Point217-220ºC
AppearanceWhite to off-white crystalline powder
Water SolubilityWater solubility: virtually insoluble; easily solu
Storage Conditionroom temperature, sealed
ApplicationClarithromycin is a macrolide antibiotic and a CYP3A4 inhibitor.
HTC29419000
PubChem ID329823068
MDL NumberMFCD00865140
SMILESO[C@@H]([C@@](O)(C)[C@@H](CC)OC([C@H](C)[C@H]1O[C@@H]2O[C@@H](C)[C@H](O)[C@](C)(OC)C2)=O)[C@@H](C)C([C@H](C)C[C@@](C)(OC)[C@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@H]1C)=O
InChI1S/C38H69NO13/c1-15-26-38(10,45)31(42)21(4)28(40)19(2)17-37(9,47-14)33(52-35-29(41)25(39(11)12)16-20(3)48-35)22(5)30(23(6)34(44)50-26)51-27-18-36(8,46-13)32(43)24(7)49-27/h19-27,29-33,35,41-43,45H,15-18H2,1-14H3/t19-,20-,21+,22+,23-,24+,25+,26-,27+,29-,30+,31-,32+,33-,35+,36-,37-,38-/m1/s1
InChI KeyAGOYDEPGAOXOCK-KCBOHYOISA-N
NACRES CodeNA.24
UNSPSC41116107
Hazard SymbolsTransport
MSDSmsds/9826_1_81103_11_9.pdf
BioactivityClarithromycin is a macrolide antibiotic and a CYP3A4 inhibitor.Target: Antibacterial; CYP3A4Clarithromycin is a macrolide antibiotic used to treat pharyngitis, tonsillitis, acute maxillary sinusitis, acute bacterial exacerbation of chronic bronchitis, pneumonia (especially atypical pneumonias associated with Chlamydophila pneumoniae), skin and skin structure infections. Clarithromycin prevents bacteria from growing by interfering with their protein synthesis. It binds to the subunit 50S of the bacterial ribosome and thus inhibits the translation of peptides. Clarithromycin has similar antimicrobial spectrum as erythromycin, but is more effective against certain Gram-negative bacteria, particularly Legionella pneumophila. Besides this bacteriostatic effect, clarithromycin also has bactericidal effect on certain strains, such as Haemophilus influenzae, Streptococcus pneumoniae and Neisseria gonorrhoeae. Clarithromycin is a CYP3A4 inhibitor. Even low doses of the cytochrome P4503A4 (CYP3A4) inhibitor clarithromycin increase the plasma concentrations and effects of repaglinide. Concomitant use of clarithromycin or other potent inhibitors of CYP3A4 with repaglinide may enhance its blood glucose-lowering effect and increase the risk of hypoglycemia [1, 2]. Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Anti-infection >> Bacterial Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450 Research Areas >> Infection References [1]. http://en.wikipedia.org/wiki/Clarithromycin [2]. Niemi, M., P.J. Neuvonen, and K.T. Kivisto, The cytochrome P4503A4 inhibitor clarithromycin increases the plasma concentrations and effects of repaglinide. Clin Pharmacol Ther, 2001. 70(1): p. 58-65. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 805.5±65.0 °C at 760 mmHg Melting Point 217-220ºC Molecular Formula C38H69NO13 Molecular Weight 747.953 Flash Point 440.9±34.3 °C Exact Mass 747.476868 PSA 182.91000 LogP 3.16 Vapour Pressure 0.0±6.5 mmHg at 25°C Index of Refraction 1.526 InChIKey AGOYDEPGAOXOCK-KCBOHYOISA-N SMILES CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(OC)CC(C)C(=O)C(C)C(O)C1(C)O
Use ofProperties Articles141 Name clarithromycin Synonym More Synonyms Clarithromycin Biological Activity Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Anti-infection >> Bacterial Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450 Research Areas >> Infection References [1]. http://en.wikipedia.org/wiki/Clarithromycin [2]. Niemi, M., P.J. Neuvonen, and K.T. Kivisto, The cytochrome P4503A4 inhibitor clarithromycin increases the plasma concentrations and effects of repaglinide. Clin Pharmacol Ther, 2001. 70(1): p. 58-65. Chemical & Physical Properties Molecular Formula C38H69NO13 Exact Mass 747.476868 PSA 182.91000 Index of Refraction 1.526 InChIKey AGOYDEPGAOXOCK-KCBOHYOISA-N
Transport InfoProduct name: Purity: 98.0%
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available
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