CAS Number85721-33-1
SynonymsCPFX; ciproiv; CIPROBAY; euciprin; Cipro; Ciprine; ciloxan; Ciprofloxacin; Cipmbay; ciprobid; Baycip; MFCD00185755
Molecular FormulaC17H18FN3O3
Molecular Weight331.34
Purity≥98 (HPLC)%
Density1.5±0.1 g/cm3
Boiling Point581.8±50.0 °C at 760 mmHg
Melting Point255-257°C
Appearancepowder or crystals
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 85721-33-1 |
| Catalog No. | 2A-9009818 |
| Chinese Name | 环丙沙星 |
| Synonyms | CPFX; ciproiv; CIPROBAY; euciprin; Cipro; Ciprine; ciloxan; Ciprofloxacin; Cipmbay; ciprobid; Baycip; MFCD00185755 |
| Molecular Formula | C17H18FN3O3 |
| Molecular Weight | 331.34 |
| Purity | ≥98 (HPLC) |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 581.8±50.0 °C at 760 mmHg |
| Melting Point | 255-257°C |
| Appearance | powder or crystals |
| Water Solubility | Water solubility: insoluble; insoluble: ethanol |
| Storage Condition | Close light, seal, store in dry place |
| Application | Ciprofloxacin is a fluoroquinolone antibiotic with highly potent antibacterial activity. |
| HTC | 3004909090 |
| PubChem ID | 329751572 |
| MDL Number | MFCD00185755 |
| SMILES | OC(=O)C1=CN(C2CC2)c3cc(N4CCNCC4)c(F)cc3C1=O |
| InChI | 1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24) |
| InChI Key | MYSWGUAQZAJSOK-UHFFFAOYSA-N |
| Beilstein/REAXYS | 3568352 |
| NACRES Code | NA.21 |
| UNSPSC | 41116105 |
| Hazard Symbols | Transport |
| MSDS | msds/9818_1_85721_33_1.pdf |
| Bioactivity | Ciprofloxacin is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection In Vitro Ciprofloxacin is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity[1]. Ciprofloxacin (CIP) shows potent activity against Y. pestis with MIC90 of 0.03 μg/mL[2]. In Vivo Ciprofloxacin (1 mg/L) induces glutathione-S-transferase (GST) activity, in contrast with inhibited GST and Catalase (CAT) of larvae exposed to enrofloxacin. Ciprofloxacin (≥10 μg/L) and enrofloxacin are ecotoxic for development, growth, detoxifying, and oxidative stress enzymes in anuran amphibian larvae[1]. In a murine model of pneumonic plague, Ciprofloxacin (30 mg/kg, i.p.) results in a drug exposure which is similar to the drug exposure observed in human following a 500 mg dose of oral Ciprofloxacin. Intraperitoneal Ciprofloxacin reduces the lung bacterial load compare to controls treated with intraperitoneal PBS[3]. Cell Assay Bacterial inocula are prepared by suspending colonies into Mueller-Hinton broth (CAMHB) (containing Ciprofloxacin) from 18 to 24 h (B. anthracis) or 42 to 48 h (Y. pestis) on sheep blood agar (SBA) plates that are incubated at 35°C. Suspended cultures are diluted with CAMHB to a bacterial cell density of 105 CFU/mL adjusted based on the optical density at 600 nm. To each well of the 96-well plate, 50 μL of dilutions is added for a final inoculum of ~5×104 CFU/well. Plates are incubated at 35°C. MICs are determined visually at 18 to 24 h (B. anthracis) or 42 to 48 h (Y. pestis) and also by absorbance at 600 nm[2]. Animal Admin Female BALB/cAnNCrl (BALB/c) mice, 8 to 10 weeks old and 20 g (±4 g) are used in this assay. A single dose of Ciprofloxacin (30 mg/kg) is administered to mice (n=30) via the intraperitoneal (i.p.) route. The mice (n=3/time point/group) are culled at 1, 10, 20, or 30 min and 1, 1.5, 2, 4, 8, 12 h following Ciprofloxacin administration and 1, 15, or 30 min and 1, 2, 4, 6, 10, 18, or 24 h following DRCFI or CFI administration. Blood sampling points are chosen based upon the short half-life of Ciprofloxacin and longer half-life of CFI. Blood and lungs (whole organ) are collected post mortem for analysis. The lung doses following CFI or DRCFI administration are calculated using the concentration of Ciprofloxacin in the lung samples at 1 min post-administration[3]. References [1]. Peltzer PM, et al. Ecotoxicity of veterinary enrofloxacin and ciprofloxacin antibiotics on anuran amphibian larvae. Environ Toxicol Pharmacol. 2017 Feb 4. pii: S1382-6689(17)30029-7 [2]. Steenbergen J, et al. In Vitro and In Vivo Activity of Omadacycline Against Two Biothreat Pathogens: Bacillus anthracis and Yersinia pestis. Antimicrob Agents Chemother. 2017 Feb 21. [3]. Hamblin KA, et al. Inhaled Liposomal Ciprofloxacin Protects against a Lethal Infection in a Murine Model of Pneumonic Plague. Front Microbiol. 2017 Feb 6;8:91. Chemical & Physical Properties Density 1.5±0.1 g/cm3 Boiling Point 581.8±50.0 °C at 760 mmHg Melting Point 255-257°C Molecular Formula C17H18FN3O3 Molecular Weight 331.341 Flash Point 305.6±30.1 °C Exact Mass 331.133209 PSA 74.57000 LogP 0.65 Vapour Pressure 0.0±1.7 mmHg at 25°C Index of Refraction 1.655 InChIKey MYSWGUAQZAJSOK-UHFFFAOYSA-N SMILES O=C(O)c1cn(C2CC2)c2cc(N3CCNCC3)c(F)cc2c1=O Storage condition Store at 0-5°C |
| Use of | Ciprofloxacin is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity. Properties Articles896 Name ciprofloxacin Synonym More Synonyms Ciprofloxacin Biological Activity Description Ciprofloxacin is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection In Vitro Ciprofloxacin is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity[1]. Ciprofloxacin (CIP) shows potent activity against Y. pestis with MIC90 of 0.03 μg/mL[2]. References [1]. Peltzer PM, et al. Ecotoxicity of veterinary enrofloxacin and ciprofloxacin antibiotics on anuran amphibian larvae. Environ Toxicol Pharmacol. 2017 Feb 4. pii: S1382-6689(17)30029-7 [2]. Steenbergen J, et al. In Vitro and In Vivo Activity of Omadacycline Against Two Biothreat Pathogens: Bacillus anthracis and Yersinia pestis. Antimicrob Agents Chemother. 2017 Feb 21. [3]. Hamblin KA, et al. Inhaled Liposomal Ciprofloxacin Protects against a Lethal Infection in a Murine Model of Pneumonic Plague. Front Microbiol. 2017 Feb 6;8:91. Chemical & Physical Properties Molecular Formula C17H18FN3O3 Exact Mass 331.133209 PSA 74.57000 Index of Refraction 1.655 InChIKey MYSWGUAQZAJSOK-UHFFFAOYSA-N |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: No dangerous goods IMDG Code: No dangerous goods International Air Transport Dangerous Regulations: No dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special precautions for users No data available |
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