CAS Number86393-32-0
Synonyms1-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid,hydrate,hydrochloride; Flociprin; Ciprobay; Cipro; Ciloxan; Ciproxan; 1-Cyclopropyl-6-fluor-4-oxo-7-piperazin-1-yl-1,4-dihydrochinolin-3-carbonsäurehydrochloridhydrat; Septicide; MFCD00079044; Ciprofloxacin hydrochloride hydrate; Ciflox; Ciprofloxacin Hydrochloride Monohydrate; Ciprofloxacin Hydrochloride; BAY O 9867; Baycip; ciprofloxacin monohydrochloride monohydrate
Molecular FormulaC17H21ClFN3O4
Molecular Weight385.82
Purity98%
Boiling Point581.8ºC at 760 mmHg
Melting Point318-320 °C
AppearanceSolid;White to Light yellow powder to crystal
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 86393-32-0 |
| Catalog No. | 2A-9009819 |
| Chinese Name | 盐酸环丙沙星 |
| Synonyms | 1-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid,hydrate,hydrochloride; Flociprin; Ciprobay; Cipro; Ciloxan; Ciproxan; 1-Cyclopropyl-6-fluor-4-oxo-7-piperazin-1-yl-1,4-dihydrochinolin-3-carbonsäurehydrochloridhydrat; Septicide; MFCD00079044; Ciprofloxacin hydrochloride hydrate; Ciflox; Ciprofloxacin Hydrochloride Monohydrate; Ciprofloxacin Hydrochloride; BAY O 9867; Baycip; ciprofloxacin monohydrochloride monohydrate |
| Molecular Formula | C17H21ClFN3O4 |
| Molecular Weight | 385.82 |
| Purity | 98 |
| Boiling Point | 581.8ºC at 760 mmHg |
| Melting Point | 318-320 °C |
| Appearance | Solid;White to Light yellow powder to crystal |
| Storage Condition | Refrigerated at 0-6°C |
| Application | Ciprofloxacin hydrochloride is a fluoroquinolone antibiotic with highly potent antibacterial activity. |
| HTC | 2933990090 |
| PubChem ID | 329823074 |
| MDL Number | MFCD00242856 |
| SMILES | O.Cl.OC(=O)C1=CN(C2CC2)c3cc(N4CCNCC4)c(F)cc3C1=O |
| InChI | 1S/C17H18FN3O3.ClH.H2O/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24;;/h7-10,19H,1-6H2,(H,23,24);1H;1H2 |
| InChI Key | ARPUHYJMCVWYCZ-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/9819_1_86393_32_0.pdf |
| Bioactivity | Ciprofloxacin hydrochloride is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity. Related Catalog Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial In Vitro Ciprofloxacin (hydrochloride monohydrate) is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity[1]. Ciprofloxacin (hydrochloride monohydrate) (CIP) shows potent activity against Y. pestis with MIC90 of 0.03 μg/mL[2]. In Vivo Ciprofloxacin (hydrochloride monohydrate) (1 mg/L) induces glutathione-S-transferase (GST) activity, in contrast with inhibited GST and Catalase (CAT) of larvae exposed to enrofloxacin. Ciprofloxacin (hydrochloride monohydrate) (≥10 μg/L) is ecotoxic for development, growth, detoxifying, and oxidative stress enzymes in anuran amphibian larvae[1]. In a murine model of pneumonic plague, Ciprofloxacin (hydrochloride monohydrate) (30 mg/kg, i.p.) results in a drug exposure which is similar to the drug exposure observed in human following a 500 mg dose of oral Ciprofloxacin (hydrochloride monohydrate). Intraperitoneal Ciprofloxacin (hydrochloride monohydrate) reduces the lung bacterial load compare to controls treated with intraperitoneal PBS[3]. Cell Assay Bacterial inocula are prepared by suspending colonies into Mueller-Hinton broth (CAMHB) (containing Ciprofloxacin (hydrochloride monohydrate)) from 18 to 24 h (B. anthracis) or 42 to 48 h (Y. pestis) on sheep blood agar (SBA) plates that are incubated at 35°C. Suspended cultures are diluted with CAMHB to a bacterial cell density of 105 CFU/mL adjusted based on the optical density at 600 nm. To each well of the 96-well plate, 50 μL of dilutions is added for a final inoculum of ~5×104 CFU/well. Plates are incubated at 35°C. MICs are determined visually at 18 to 24 h (B. anthracis) or 42 to 48 h (Y. pestis) and also by absorbance at 600 nm[2]. Animal Admin Female BALB/cAnNCrl (BALB/c) mice, 8 to 10 weeks old and 20 g (±4 g) are used in this assay. A single dose of Ciprofloxacin (hydrochloride monohydrate) (30 mg/kg) is administered to mice (n=30) via the intraperitoneal (i.p.) route. The mice (n=3/time point/group) are culled at 1, 10, 20, or 30 min and 1, 1.5, 2, 4, 8, 12 h following Ciprofloxacin (hydrochloride monohydrate) administration and 1, 15, or 30 min and 1, 2, 4, 6, 10, 18, or 24 h following DRCFI or CFI administration. Blood sampling points are chosen based upon the short half-life of Ciprofloxacin (hydrochloride monohydrate) and longer half-life of CFI. Blood and lungs (whole organ) are collected post mortem for analysis. The lung doses following CFI or DRCFI administration are calculated using the concentration of Ciprofloxacin (hydrochloride monohydrate) in the lung samples at 1 min post-administration[3]. References [1]. Peltzer PM, et al. Ecotoxicity of veterinary enrofloxacin and ciprofloxacin antibiotics on anuran amphibian larvae. Environ Toxicol Pharmacol. 2017 Feb 4. pii: S1382-6689(17)30029-7. [2]. Steenbergen J, et al. In Vitro and In Vivo Activity of Omadacycline Against Two Biothreat Pathogens: Bacillus anthracis and Yersinia pestis. Antimicrob Agents Chemother. 2017 Feb 21. [3]. Hamblin KA, et al. Inhaled Liposomal Ciprofloxacin Protects against a Lethal Infection in a Murine Model of Pneumonic Plague. Front Microbiol. 2017 Feb 6;8:91. Chemical & Physical Properties Boiling Point 581.8ºC at 760 mmHg Melting Point 318-320 °C Molecular Formula C17H21ClFN3O4 Molecular Weight 385.818 Flash Point 305.6ºC Exact Mass 385.120453 PSA 83.80000 LogP 2.71480 InChIKey ARPUHYJMCVWYCZ-UHFFFAOYSA-N SMILES Cl.O.O=C(O)c1cn(C2CC2)c2cc(N3CCNCC3)c(F)cc2c1=O Storage condition 0-6°C |
| Use of | Ciprofloxacin hydrochloride is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity. Properties Articles88 Name ciprofloxacin hydrochloride hydrate Synonym More Synonyms Ciprofloxacin Hydrochloride hydrate Biological Activity Description Ciprofloxacin hydrochloride is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity. Related Catalog Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial In Vitro Ciprofloxacin (hydrochloride monohydrate) is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity[1]. Ciprofloxacin (hydrochloride monohydrate) (CIP) shows potent activity against Y. pestis with MIC90 of 0.03 μg/mL[2]. References [1]. Peltzer PM, et al. Ecotoxicity of veterinary enrofloxacin and ciprofloxacin antibiotics on anuran amphibian larvae. Environ Toxicol Pharmacol. 2017 Feb 4. pii: S1382-6689(17)30029-7. [2]. Steenbergen J, et al. In Vitro and In Vivo Activity of Omadacycline Against Two Biothreat Pathogens: Bacillus anthracis and Yersinia pestis. Antimicrob Agents Chemother. 2017 Feb 21. [3]. Hamblin KA, et al. Inhaled Liposomal Ciprofloxacin Protects against a Lethal Infection in a Murine Model of Pneumonic Plague. Front Microbiol. 2017 Feb 6;8:91. Chemical & Physical Properties Exact Mass 385.120453 PSA 83.80000 LogP 2.71480 InChIKey ARPUHYJMCVWYCZ-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
| Related Products in API & Advanced Intermediates | ||
|---|---|---|
| Chlorotetracycline | 57-62-5 | 2A-9009749 |
| Chlortetracycline hydrochloride | 64-72-2 | 2A-9009761 |
| Cimetidine | 51481-61-9 | 2A-9009795 |
| Cimetidine hydrochloride | 70059-30-2 | 2A-9009796 |
| Ciprofloxacin | 85721-33-1 | 2A-9009818 |
| Ciprofloxacin lactate | 97867-33-9 | 2A-9009820 |
| Clarithromycin | 81103-11-9 | 2A-9009826 |
| Clindamycin | 18323-44-9 | 2A-0201883 |
| Clindamycin hydrochloride | 21462-39-5 | 2A-9009836 |
| Clindamycin palmitate | 36688-78-5 | 2A-9009837 |
| Browse all API & Advanced Intermediates products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS