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Cefazolin structure, CAS 25953-19-9

Cefazolin

CAS Number25953-19-9

SynonymsCephazolin; Cephamezine; Cefazolinum; Cefazolina; Cephazoline; Cefazoline; Cephazolidin; Ancef; MFCD00243010; EINECS 247-362-8; Cefazolin; Cefamezin; Cefazolin Acid

Molecular FormulaC14H14N8O4S3

Molecular Weight454.51

Purity98%

Density2.0±0.1 g/cm3

Boiling Point

Melting Point198-200ºC

Flash Point

Appearanceacicular

EINECS

MSDSChineseEnglish

Symbol

Signal Word

Cat. No.: 2A-9009627 Purity: 98%
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Quality Control of [ 25953-19-9 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number25953-19-9
Catalog No.2A-9009627
Chinese Name头孢唑林
SynonymsCephazolin; Cephamezine; Cefazolinum; Cefazolina; Cephazoline; Cefazoline; Cephazolidin; Ancef; MFCD00243010; EINECS 247-362-8; Cefazolin; Cefamezin; Cefazolin Acid
Molecular FormulaC14H14N8O4S3
Molecular Weight454.51
Purity98
Density2.0±0.1 g/cm3
Melting Point198-200ºC
Appearanceacicular
Storage ConditionRoom Temperature
ApplicationCefazolin is a first-generation cephalosporin antibiotic used in the research of a variety of bacterial infections.
HTC3004909090
SMILES[s]1c(nnc1C)SCC2=C(N3[C@H](SC2)[C@@H](C3=O)NC(=O)C[n]4nnnc4)C(=O)O
InChI1S/C14H14N8O4S3/c1-6-17-18-14(29-6)28-4-7-3-27-12-9(11(24)22(12)10(7)13(25)26)16-8(23)2-21-5-15-19-20-21/h5,9,12H,2-4H2,1H3,(H,16,23)(H,25,26)/t9-,12-/m1/s1
InChI KeyMLYYVTUWGNIJIB-BXKDBHETSA-N
NACRES CodeNA.24
UNSPSC41116107
MSDSmsds/9627_1_25953_19_9.pdf
Use ofCefazolin is an antibiotic used for the research of a number of anti-bacterial infections. Cefazolin can be used for the prophylaxis of surgical antimicrobial. Cefazolin has anti-inflammatory effect and can attenuate post-operative cognitive dysfunction (POCD)[1]. Properties Articles48 Name cefazolin Synonym More Synonyms Cefazolin Biological Activity Description Cefazolin is an antibiotic used for the research of a number of anti-bacterial infections. Cefazolin can be used for the prophylaxis of surgical antimicrobial. Cefazolin has anti-inflammatory effect and can attenuate post-operative cognitive dysfunction (POCD)[1]. Related Catalog Research Areas >> Infection Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease Signaling Pathways >> Anti-infection >> Bacterial Antibiotic[1] References [1]. Peng Liang, et al. Perioperative use of cefazolin ameliorates postoperative cognitive dysfunction but induces gut inflammation in mice. J Neuroinflammation. 2018 Aug 22;15(1):235. Chemical & Physical Properties Molecular Formula C14H14N8O4S3 Exact Mass 454.029999 PSA 234.93000 Index of Refraction 1.961 InChIKey MLYYVTUWGNIJIB-BXKDBHETSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 3-(((5-methyl-1,3,4-thiadiazol-2-yl) thio)methyl)-8-oxo-7-(2-(1H-tetrazol-1-yl)acetamido)- CAS REGISTRY NUMBER : 25953-19-9 LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C14-H14-N8-O4-S3 MOLECULAR WEIGHT : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : BYYADW Byoin Yakugaku. Hospital Pharmacology. (Yakuji Nippon Sha, 1-11 Izumi-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1975- Volume(issue)/page/year: 3,220,1978 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : BYYADW Byoin Yakugaku. Hospital Pharmacology. (Yakuji Nippon Sha, 1-11 Izumi-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1975- Volume(issue)/page/year: 3,220,1978 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Blood - normocytic anemia Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases REFERENCE : NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 28(Suppl 7),1089,1980 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases Related to Chronic Data - death REFERENCE : NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 28(Suppl 7),1007,1980 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : TOXIC EFFECTS : Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) REFERENCE : BYYADW Byoin Yakugaku. Hospital Pharmacology. (Yakuji Nippon Sha, 1-11 Izumi-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1975- Volume(issue)/page/year: 3,220,1978 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - A1317 No. of Facilities: 33 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 528 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - A1317 No. of Facilities: 318 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 16111 (estimated) No. of Female Employees: 13596 (estimated) Safety Information Hazard Codes Xn Safety Phrases 26-36 RIDADR NONH for all modes of transport HS Code 3004909090 Synthetic Route Cephazolin sodium CAS#:27164-46-1 CAS#:25953-19-9 2-(1H-tetrazol-... CAS#:43194-95-2 (6R-trans)-7-am... CAS#:98493-37-9 CAS#:25953-19-9 Literature: Tetrahedron, , vol. 41, # 22 p. 5133 - 5139 7-((tetrazol-1'... CAS#:32510-61-5 2-Mercapto-5-me... CAS#:29490-19-5 CAS#:25953-19-9 Literature: Tetrahedron Letters, , vol. 38, # 26 p. 4693 - 4696 Precursor & DownStream Precursor 9 CAS#:27164-46-1 Cephazolin sodium CAS#:43194-95-2 2-(1H-tetrazol-... CAS#:98493-37-9 (6R-trans)-7-am... CAS#:29490-19-5 2-Mercapto-5-me... DownStream 0
Transport InfoProduct Name: Cefazolin
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