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Carbenoxolone structure, CAS 5697-56-3

Carbenoxolone

CAS Number5697-56-3

SynonymsCARBENOXOLONE(RG); bioral; CARBENOXOLONE [U; glycyrrhetinic acid hydrogen succinate; 2-Methylidene-2,3-dihydrofuran-3-one; biogastrone; Carbenoxolon; EINECS 227-174-2; MFCD00867458

Molecular FormulaC34H50O7

Molecular Weight570.77

Purity98%

Density1.20

Boiling Point687.4ºC at 760 mmHg

Melting Point291-294 °C

Flash Point

AppearanceWhite crystalline powder

EINECS

MSDSChineseEnglish

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Cat. No.: 2A-9009577 Purity: 98%
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Quality Control of [ 5697-56-3 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number5697-56-3
Catalog No.2A-9009577
Chinese Name甘珀酸
SynonymsCARBENOXOLONE(RG); bioral; CARBENOXOLONE [U; glycyrrhetinic acid hydrogen succinate; 2-Methylidene-2,3-dihydrofuran-3-one; biogastrone; Carbenoxolon; EINECS 227-174-2; MFCD00867458
Molecular FormulaC34H50O7
Molecular Weight570.77
Purity98
Density1.20
Boiling Point687.4ºC at 760 mmHg
Melting Point291-294 °C
AppearanceWhite crystalline powder
Storage ConditionKeep away from light, cool and dry place, sealed a
ApplicationCarbenoxolone is a semisynthetic derivative of glycyrrhetinic acid and is widely used in the treatment of dyspepsia and peptic ulcers due to its anti-inflammatory properties. Carbenoxolone, a hemichan
HTC2938909030
MDL NumberMFCD20926283
SMILESCC1(C(=O)O)CCC2(C)CCC3(C)C(=CC(=O)C4C5(C)CCC(OC(=O)CCC(=O)O)C(C)(C)C5CCC43C)C2C1
InChIInChI=1S/C34H50O7.2Na/c1-29(2)23-10-13-34(7)27(32(23,5)12-11-24(29)41-26(38)9-8-25(36)37)22(35)18-20-21-19-31(4,28(39)40)15-14-30(21,3)16-17-33(20,34)6;;/h18,21,23-24,27H,8-17,19H2,1-7H3,(H,36,37)(H,39,40);;/q;2*+1/p-2/t21?,23-,24-,27+,30?,31-,32?,33+,34?;;/m0../s1
InChI KeyOBZHEBDUNPOCJG-QATWLOCDSA-N
MSDSmsds/9577_1_5697_56_3.pdf
BioactivityCarbenoxolone, a semi-synthetic derivative of glycyrrhetinic acid, has previously been used for the management of dyspepsia and peptic ulcer because of its anti-inflammatory properties[3]. Carbenoxolone, a general hemichannel and gap junction inhibitor, has the therapeutic potential of carbenoxolone in the treatment of chronic liver disease[2]. Carbenoxolone is a suitable candidate for the inhibition of Aβ42 aggregation and the therapeutic potential of Cbx against AD[1]. Carbenoxolone is small molecule Pannexin1 (Panx1,is an ATP release channel) inhibitor, attenuate Panx1 channel activity through modulation of the first extracellular loop[4].Carbenoxolone is an 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor that converts inactive glucocorticoid into an active form. Carbenoxolone has antiviral activity against DENV infection targeting the virus itself[6]. Related Catalog Research Areas >> Infection Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease References [1]. Sharma S, et al. Inhibition of Alzheimer's amyloid-beta aggregation in-vitro by carbenoxolone:Insight into mechanism of action. Neurochem Int. 2017 Sep;108:481-493. [2]. Crespo Yanguas S, et al. TAT-Gap19 and Carbenoxolone Alleviate Liver Fibrosis in Mice. Int J Mol Sci. 2018 Mar 12;19(3). pii: E817. [3]. Hirata K, et al. Formulation of carbenoxolone for delivery to the skin. Int J Pharm. 2013 May 20;448(2):360-5. [4]. Michalski K, et al. Carbenoxolone inhibits Pannexin1 channels through interactions in the first extracellular loop. J Gen Physiol. 2016 Feb;147(2):165-74. [5]. Kim J, et al. Protective effect of carbenoxolone on ER stress-induced cell death in hypothalamic neurons. Biochem Biophys Res Commun. 2015 Dec 25;468(4):793-9. [6]. Pu J, et al. Antiviral activity of Carbenoxolone disodium against dengue virus infection. J Med Virol. 2017 Apr;89(4):571-581 Chemical & Physical Properties Density 1.20 Boiling Point 687.4ºC at 760 mmHg Melting Point 291-294 °C Molecular Formula C34H50O7 Molecular Weight 570.75700 Flash Point 211.6ºC Exact Mass 570.35600 PSA 117.97000 LogP 6.82830 InChIKey OBZHEBDUNPOCJG-QATWLOCDSA-N SMILES CC1(C(=O)O)CCC2(C)CCC3(C)C(=CC(=O)C4C5(C)CCC(OC(=O)CCC(=O)O)C(C)(C)C5CCC43C)C2C1
Use ofProperties Name Carbenoxolone Synonym More Synonyms Carbenoxolone Biological Activity Related Catalog Research Areas >> Infection Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease References [1]. Sharma S, et al. Inhibition of Alzheimer's amyloid-beta aggregation in-vitro by carbenoxolone:Insight into mechanism of action. Neurochem Int. 2017 Sep;108:481-493. [2]. Crespo Yanguas S, et al. TAT-Gap19 and Carbenoxolone Alleviate Liver Fibrosis in Mice. Int J Mol Sci. 2018 Mar 12;19(3). pii: E817. [3]. Hirata K, et al. Formulation of carbenoxolone for delivery to the skin. Int J Pharm. 2013 May 20;448(2):360-5. [5]. Kim J, et al. Protective effect of carbenoxolone on ER stress-induced cell death in hypothalamic neurons. Biochem Biophys Res Commun. 2015 Dec 25;468(4):793-9. [6]. Pu J, et al. Antiviral activity of Carbenoxolone disodium against dengue virus infection. J Med Virol. 2017 Apr;89(4):571-581 Chemical & Physical Properties Molecular Formula C34H50O7 Exact Mass 570.35600 PSA 117.97000 LogP 6.82830 InChIKey OBZHEBDUNPOCJG-QATWLOCDSA-N
Transport InfoProduct Name: Carbenic acid
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