CAS Number22232-54-8
SynonymsCarbimazolum; Ethyl 3-methyl-2-thioxo-2,3-dihydro-1H-imidazole-1-carboxylate; EINECS 244-854-4; Carbimazol; Carbimazole; Neo-Thyreostat; 3-Methyl-2-thioxo-2,3-dihydro-imidazol-1-carbonsaeure-aethylester; 1-Methyl-3-carbethoxy-2-thioglyoxalone; 1H-Imidazole-1-carboxylic acid, 2,3-dihydro-3-methyl-2-thioxo-, ethyl ester; CG 1; Thyrostat; ethyl 3-methyl-2-thionoimidazoline-1-carboxylate; Carbethoxymethimazole; 3-methyl-2-thioxo-2,3-dihydro-imidazole-1-carboxylic acid ethyl ester; ethyl 3-methyl-2-sulfanylideneimidazole-1-carboxylate; 3-methyl-1-ethoxycarbonylimidazoline-2-thione; Carbinazole; 2,3-Dihydro-3-methyl-2-thioxo-1H-imidazole-1-carboxylic Acid Ethyl Ester; Athyromazole; 1-Ethoxycarbonyl-3-methyl-2-thioxo-4-imidazoline; MFCD00027421; Neomercazole; 1-Ethoxycarbonyl-3-methyl-2-thio-4-im
Molecular FormulaC7H10N2O2S
Molecular Weight186.23
Purity≥98 (HPLC)%
Density1.3±0.1 g/cm3
Boiling Point240.4±23.0 °C at 760 mmHg
Melting Point124°C
Appearancepowder
EINECS244-854-4
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 22232-54-8 |
| Catalog No. | 2A-9009580 |
| Chinese Name | 卡比吗唑 |
| Synonyms | Carbimazolum; Ethyl 3-methyl-2-thioxo-2,3-dihydro-1H-imidazole-1-carboxylate; EINECS 244-854-4; Carbimazol; Carbimazole; Neo-Thyreostat; 3-Methyl-2-thioxo-2,3-dihydro-imidazol-1-carbonsaeure-aethylester; 1-Methyl-3-carbethoxy-2-thioglyoxalone; 1H-Imidazole-1-carboxylic acid, 2,3-dihydro-3-methyl-2-thioxo-, ethyl ester; CG 1; Thyrostat; ethyl 3-methyl-2-thionoimidazoline-1-carboxylate; Carbethoxymethimazole; 3-methyl-2-thioxo-2,3-dihydro-imidazole-1-carboxylic acid ethyl ester; ethyl 3-methyl-2-sulfanylideneimidazole-1-carboxylate; 3-methyl-1-ethoxycarbonylimidazoline-2-thione; Carbinazole; 2,3-Dihydro-3-methyl-2-thioxo-1H-imidazole-1-carboxylic Acid Ethyl Ester; Athyromazole; 1-Ethoxycarbonyl-3-methyl-2-thioxo-4-imidazoline; MFCD00027421; Neomercazole; 1-Ethoxycarbonyl-3-methyl-2-thio-4-im |
| Molecular Formula | C7H10N2O2S |
| Molecular Weight | 186.23 |
| Purity | ≥98 (HPLC) |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 240.4±23.0 °C at 760 mmHg |
| Melting Point | 124°C |
| Appearance | powder |
| Storage Condition | Keep receptacle sealed Store in a compact containe |
| Application | Carbimazole has antihyperthyroidism activity. |
| EINECS | 244-854-4 |
| HTC | 2922499915 |
| SMILES | S=[c]1[n](cc[n]1C(=O)OCC)C |
| InChI | 1S/C7H10N2O2S/c1-3-11-7(10)9-5-4-8(2)6(9)12/h4-5H,3H2,1-2H3 |
| InChI Key | CFOYWRHIYXMDOT-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | Transport |
| MSDS | msds/9580_1_22232_54_8.pdf |
| Bioactivity | Carbimazole is an imidazole antithyroid agent. Target: OthersCarbimazole is an effective thyroid hormone inhibitor under a class of drugs known as pro-drugs. It is considered a pro-drug because it converts to methimazole after being absorbed by the body, generating an antithyroid action that works against hyperthyroidism (excessive production of thyroid hormones) and thyrotoxicosis (inflammation of the thyroid gland) [1]. Methimazole prevents the thyroid peroxidase enzyme from coupling and iodinating the tyrosine residues on thyroglobulin, hence reducing the production of the thyroid hormones T3 and T4 (thyroxine) [2].Carbimazole (CBZ) is one of the major drugs currently used for the treatment of Graves' disease. Experiments with [35S] CBZ in rats showed that the drug is so rapidly transformed to MMI after i.v. injection (within 3 min) that very little of the unchanged drug would be expected to reach the thyroid gland. The antithyroid action of CBZ in rats, therefore, can be ascribed entirely to the MMI to which it is rapidly converted [3]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Endocrinology References [1]. Taurog, A., The mechanism of action of the thioureylene antithyroid drugs. Endocrinology, 1976. 98(4): p. 1031-46. [2]. Magnusson, R.P., A. Taurog, and M.L. Dorris, Mechanism of iodide-dependent catalatic activity of thyroid peroxidase and lactoperoxidase. J Biol Chem, 1984. 259(1): p. 197-205. [3]. Nakashima, T. and A. Taurog, Rapid conversion of carbimazole to methimazole in serum; evidence for an enzymatic mechanism. Clin Endocrinol (Oxf), 1979. 10(6): p. 637-48. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 240.4±23.0 °C at 760 mmHg Melting Point 124°C Molecular Formula C7H10N2O2S Molecular Weight 186.232 Flash Point 99.2±22.6 °C Exact Mass 186.046295 PSA 68.25000 LogP 0.34 Vapour Pressure 0.0±0.5 mmHg at 25°C Index of Refraction 1.612 InChIKey CFOYWRHIYXMDOT-UHFFFAOYSA-N SMILES CCOC(=O)n1ccn(C)c1=S Storage condition Refrigerator |
| Use of | Properties Articles33 Name carbimazole Synonym More Synonyms Carbimazole Biological Activity Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Endocrinology References [1]. Taurog, A., The mechanism of action of the thioureylene antithyroid drugs. Endocrinology, 1976. 98(4): p. 1031-46. [2]. Magnusson, R.P., A. Taurog, and M.L. Dorris, Mechanism of iodide-dependent catalatic activity of thyroid peroxidase and lactoperoxidase. J Biol Chem, 1984. 259(1): p. 197-205. [3]. Nakashima, T. and A. Taurog, Rapid conversion of carbimazole to methimazole in serum; evidence for an enzymatic mechanism. Clin Endocrinol (Oxf), 1979. 10(6): p. 637-48. Chemical & Physical Properties Molecular Formula C7H10N2O2S Exact Mass 186.046295 PSA 68.25000 Index of Refraction 1.612 InChIKey CFOYWRHIYXMDOT-UHFFFAOYSA-N Storage condition Refrigerator |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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