| Chemical & Physical Properties | |
|---|---|
| CAS Number | 145040-37-5 |
| Catalog No. | 2A-9009558 |
| Chinese Name | 坎地沙坦酯 |
| Synonyms | Candesartan cilexetil; MFCD00871371; Candesartan (Cilexetil) |
| Molecular Formula | C33H34N6O6 |
| Molecular Weight | 610.66 |
| Purity | 98 |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 843.3±75.0 °C at 760 mmHg |
| Melting Point | 168-170?C |
| Appearance | powder |
| Water Solubility | Slightly soluble: methanol; very slightly soluble: |
| Storage Condition | -20°C Freezer |
| Application | Candesartan Cilexetil (TCV-116) is an angiotensin II antagonist used for hypertension. |
| HTC | 2933990090 |
| MDL Number | MFCD00871371 |
| SMILES | CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc4ccc(cc4)-c5ccccc5-c6nnn[nH]6 |
| InChI | 1S/C33H34N6O6/c1-3-42-32-34-28-15-9-14-27(31(40)43-21(2)44-33(41)45-24-10-5-4-6-11-24)29(28)39(32)20-22-16-18-23(19-17-22)25-12-7-8-13-26(25)30-35-37-38-36-30/h7-9,12-19,21,24H,3-6,10-11,20H2,1-2H3,(H,35,36,37,38) |
| InChI Key | GHOSNRCGJFBJIB-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/9558_1_145040_37_5.pdf |
| Bioactivity | Candesartan Cilexetil (TCV-116) is an angiotensin II receptor antagonist used mainly for the treatment of hypertension.Target: Type-1 angiotensin II receptorCandesartan is generally well tolerated and significantly reduced cardiovascular deaths and hospital admissions for heart failure. Ejection fraction or treatment at baseline did not alter these effects [1]. In rats, TCV-116 inhibited the pressor responses to Ang I, Ang II, and Ang III without an effect on the bradykinin (BK)-induced depressor response. In SHR, the antihypertensive effect of TCV-116 (10 mg/kg) was larger than the maximum antihypertensive effect of enalapril and was not intensified by combination with enalapril. TCV-116 is more effective than enalapril in reducing blood pressure in SHR and 1K, 1C-HR, and that the BK- and/or prostaglandin-potentiating effect of enalapril contributes little to its antihypertensive mechanism in SHR [2]. Related Catalog Signaling Pathways >> GPCR/G Protein >> Angiotensin Receptor Research Areas >> Cardiovascular Disease References [1]. Pfeffer, M.A., et al., Effects of candesartan on mortality and morbidity in patients with chronic heart failure: the CHARM-Overall programme. Lancet, 2003. 362(9386): p. 759-66. [2]. Wada, T., et al., Comparison of the antihypertensive effects of the new angiotensin II (AT1) receptor antagonist candesartan cilexetil (TCV-116) and the angiotensin converting enzyme inhibitor enalapril in rats. Hypertens Res, 1996. 19(2): p. 75-81. Chemical & Physical Properties Density 1.4±0.1 g/cm3 Boiling Point 843.3±75.0 °C at 760 mmHg Melting Point 168-170?C Molecular Formula C33H34N6O6 Molecular Weight 610.660 Flash Point 463.8±37.1 °C Exact Mass 610.253967 PSA 143.34000 LogP 7.79 Vapour Pressure 0.0±3.1 mmHg at 25°C Index of Refraction 1.667 InChIKey GHOSNRCGJFBJIB-UHFFFAOYSA-N SMILES CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 Storage condition -20°C Freezer |
| Use of | Properties Articles29 Name Candesartan cilexetil Synonym More Synonyms Candesartan cilexetil Biological Activity Related Catalog Signaling Pathways >> GPCR/G Protein >> Angiotensin Receptor Research Areas >> Cardiovascular Disease References [1]. Pfeffer, M.A., et al., Effects of candesartan on mortality and morbidity in patients with chronic heart failure: the CHARM-Overall programme. Lancet, 2003. 362(9386): p. 759-66. [2]. Wada, T., et al., Comparison of the antihypertensive effects of the new angiotensin II (AT1) receptor antagonist candesartan cilexetil (TCV-116) and the angiotensin converting enzyme inhibitor enalapril in rats. Hypertens Res, 1996. 19(2): p. 75-81. Chemical & Physical Properties Molecular Formula C33H34N6O6 Exact Mass 610.253967 PSA 143.34000 Index of Refraction 1.667 InChIKey GHOSNRCGJFBJIB-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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