CAS Number139481-59-7
Synonyms2-ethoxy-1-{[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylic acid; 2-Ethoxy-1-{[2'-(1H-tetrazol-5-yl)-4-biphenylyl]methyl}-1H-benzimidazole-7-carboxylic acid; Ratacand; Candesartan; Blopress; Amias; Atacand; 2-Ethoxy-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylic acid; 2-Ethoxy-1-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-1H-benzimidazole-7-carboxylic Acid; 2-(ethyloxy)-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylic acid; MFCD00864463; 2-Ethoxy-1-{[2'-(2H-tetrazol-5-yl)-4-biphenylyl]methyl}-1H-benzimidazole-7-carboxylic acid
Molecular FormulaC24H20N6O3
Molecular Weight440.45
Purity98%
Density1.4±0.1 g/cm3
Boiling Point754.8±70.0 °C at 760 mmHg
Melting Point183-185°C
Appearancecrystalline solid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 139481-59-7 |
| Catalog No. | 2A-0201366 |
| Chinese Name | 坎地沙坦 |
| Synonyms | 2-ethoxy-1-{[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylic acid; 2-Ethoxy-1-{[2'-(1H-tetrazol-5-yl)-4-biphenylyl]methyl}-1H-benzimidazole-7-carboxylic acid; Ratacand; Candesartan; Blopress; Amias; Atacand; 2-Ethoxy-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylic acid; 2-Ethoxy-1-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-1H-benzimidazole-7-carboxylic Acid; 2-(ethyloxy)-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylic acid; MFCD00864463; 2-Ethoxy-1-{[2'-(2H-tetrazol-5-yl)-4-biphenylyl]methyl}-1H-benzimidazole-7-carboxylic acid |
| Molecular Formula | C24H20N6O3 |
| Molecular Weight | 440.45 |
| Purity | 98 |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 754.8±70.0 °C at 760 mmHg |
| Melting Point | 183-185°C |
| Appearance | crystalline solid |
| Storage Condition | -20°C Freezer |
| Application | Candesartan is an angiotensin II receptor antagonist with an IC50 of 0.26 nM. |
| HTC | 2933990090 |
| MDL Number | MFCD00864463 |
| SMILES | [nH]1nnnc1c2c(cccc2)c3ccc(cc3)C[n]4c5c(nc4OCC)cccc5C(=O)O |
| InChI | 1S/C24H20N6O3/c1-2-33-24-25-20-9-5-8-19(23(31)32)21(20)30(24)14-15-10-12-16(13-11-15)17-6-3-4-7-18(17)22-26-28-29-27-22/h3-13H,2,14H2,1H3,(H,31,32)(H,26,27,28,29) |
| InChI Key | HTQMVQVXFRQIKW-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/9557_1_139481_59_7.pdf |
| Use of | Properties Name 1-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylic acid Synonym More Synonyms Candesartan Biological Activity Related Catalog Signaling Pathways >> GPCR/G Protein >> Angiotensin Receptor Research Areas >> Cardiovascular Disease References [1]. Pfeffer MA, et al. Effects of candesartan on mortality and morbidity in patients with chronic heart failure: the CHARM-Overall programme. Lancet. 2003 Sep 6;362(9386):759-66. [2]. Nishimura Y, et al. Chronic peripheral administration of the angiotensin II AT(1) receptor antagonist candesartan blocks brain AT(1) receptors. Brain Res. 2000 Jul 14;871(1):29-38. Chemical & Physical Properties Molecular Formula C24H20N6O3 Exact Mass 440.159698 PSA 118.81000 Index of Refraction 1.719 InChIKey HTQMVQVXFRQIKW-UHFFFAOYSA-N Safety Information Hazard Codes Xn: Harmful; RIDADR NONH for all modes of transport HS Code 2933990090 Synthetic Route Candesartan Met... 139481-69-9 Candesartan 139481-59-7 ethyl 2-ethoxy-... 856414-35-2 Candesartan 139481-59-7 Literature: ALGRY QUIMICA, S.L Patent: EP1833801 B1, 2008 ; Location in patent: Page/Page column 17; 18 ; Candesartan eth... 139481-58-6 Candesartan 139481-59-7 Precursor & DownStream Precursor 9 CAS#:139481-69-9 Candesartan Met... CAS#:856414-35-2 ethyl 2-ethoxy-... CAS#:139481-58-6 Candesartan eth... CAS#:21606-04-2 1-Methyl-3-nitr... DownStream 3 CAS#:139481-72-4 Trityl candesartan CAS#:145040-37-5 Candesartan cil... CAS#:170791-09-0 Trityl Candesar... |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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