CAS Number179324-69-7
Synonyms[(1R)-3-methyl-1-({(2S)-3-phenyl-2-[(pyrazin-2-ylcarbonyl)amino]propanoyl}amino)butyl]boronic acid; Radiciol; Bortezomib; dpba; BortezMib; N-[(1R)-1-(Dihydroxyboryl)-3-methylbutyl]-Nα-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide; MFCD05260688; BortezoMib-D8; N-[(1R)-1-(Dihydroxyboryl)-3-methylbutyl]-Nα-(2-pyrazinylcarbonyl)-L-phenylalaninamide; Velcade; N-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-Nα-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide; BortezoMib Base; MG-341 PS-341
Molecular FormulaC19H25BN4O4
Molecular Weight384.24
Purity≥98 (LC/MS)%
Density1.2±0.1 g/cm3
Melting Point122-124°C
Appearancesolid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 179324-69-7 |
| Catalog No. | 2A-9009431 |
| Chinese Name | 硼替佐米 |
| Synonyms | [(1R)-3-methyl-1-({(2S)-3-phenyl-2-[(pyrazin-2-ylcarbonyl)amino]propanoyl}amino)butyl]boronic acid; Radiciol; Bortezomib; dpba; BortezMib; N-[(1R)-1-(Dihydroxyboryl)-3-methylbutyl]-Nα-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide; MFCD05260688; BortezoMib-D8; N-[(1R)-1-(Dihydroxyboryl)-3-methylbutyl]-Nα-(2-pyrazinylcarbonyl)-L-phenylalaninamide; Velcade; N-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-Nα-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide; BortezoMib Base; MG-341 PS-341 |
| Molecular Formula | C19H25BN4O4 |
| Molecular Weight | 384.24 |
| Purity | ≥98 (LC/MS) |
| Density | 1.2±0.1 g/cm3 |
| Melting Point | 122-124°C |
| Appearance | solid |
| Water Solubility | Water solubility: soluble; water solubility: 76 mg |
| Storage Condition | Hygroscopic, -20°C Freezer, Under Inert Atmosphere |
| Application | Bortezomib is a potent 20S proteasome inhibitor with a Ki of 0.6 nM. |
| HTC | 2934999090 |
| MDL Number | MFCD09056737 |
| SMILES | B(O)(O)[C@@H](NC(=O)[C@@H](NC(=O)c2nccnc2)Cc1ccccc1)CC(C)C |
| InChI | 1S/C19H25BN4O4/c1-13(2)10-17(20(27)28)24-18(25)15(11-14-6-4-3-5-7-14)23-19(26)16-12-21-8-9-22-16/h3-9,12-13,15,17,27-28H,10-11H2,1-2H3,(H,23,26)(H,24,25)/t15-,17-/m0/s1 |
| InChI Key | GXJABQQUPOEUTA-RDJZCZTQSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| MSDS | msds/9431_1_179324_69_7.pdf |
| Use of | Bortezomib (PS-341) is a potent 20S proteasome inhibitor with a Ki of 0.6 nM. Properties Name bortezomib Synonym More Synonyms Bortezomib (PS-341) Biological Activity Description Bortezomib (PS-341) is a potent 20S proteasome inhibitor with a Ki of 0.6 nM. Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Metabolic Enzyme/Protease >> Proteasome Research Areas >> Cancer Ki: 0.6 nM (20S proteasome)[1] Cell Assay The human PC-3 prostate tumor cells are treated with Bortezomib (0.1 nM, 1 nM, 10 nM, 100 nM, 1 μM, 10 μM) for 24-48 h in complete medium. Cytotoxicity is measured using a MTT assay[1]. References [1]. Adams J, et al. Proteasome inhibitors: a novel class of potent and effective antitumor agents. Cancer Res. 1999 Jun 1;59(11):2615-22. [2]. Boccadoro M, et al. Preclinical evaluation of the proteasome inhibitor bortezomib in cancer therapy. Cancer Cell Int. 2005 Jun 1;5(1):18. [4]. Yamamoto S, et al. Behavioral and pharmacological characteristics of bortezomib-induced peripheral neuropathy in rats. J Pharmacol Sci. 2015 Sep;129(1):43-50. Chemical & Physical Properties Molecular Formula C19H25BN4O4 Exact Mass 384.196899 PSA 124.44000 Index of Refraction 1.564 InChIKey GXJABQQUPOEUTA-RDJZCZTQSA-N Stability Hygroscopic and Moisture Sensitive Safety Information Hazard Codes Xi RIDADR 3261 HS Code 2934999090 Synthetic Route BORTEZOMIB-PINA... CAS#:205393-22-2 Bortezomib (PS-341) CAS#:179324-69-7 CAS#:1029701-48-1 Bortezomib (PS-341) CAS#:179324-69-7 Literature: Journal of the American Chemical Society, , vol. 130, # 22 p. 6910 - 6911 Pyrazine-2-carb... CAS#:98-97-5 (S)-2-amino-N-(... CAS#:1029701-41-4 Bortezomib (PS-341) CAS#:179324-69-7 Literature: Journal of the American Chemical Society, , vol. 130, # 22 p. 6910 - 6911 Precursor & DownStream Precursor 6 CAS#:205393-22-2 BORTEZOMIB-PINA... CAS#:98-97-5 Pyrazine-2-carb... CAS#:1029701-41-4 (S)-2-amino-N-(... CAS#:789472-91-9 (S)-2-Amino-N-(... DownStream 1 CAS#:114457-94-2 N-(2-Pyrazinylc... |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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