EN
0
Home > Products > Pharmaceuticals & Life Science > API & Advanced Intermediates > Betamethasone-17-valerate
Betamethasone-17-valerate structure, CAS 2152-44-5

Betamethasone-17-valerate

CAS Number2152-44-5

Synonyms(11β,16β)-9-fluoro-11,21-dihydroxy-16-methyl-3,20-dioxopregna-1,4-dien-17-yl pentanoate; 9-Fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione-17-valerate; β-Methasone-17-valerate; (11b,16b)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione 17-Valerate; Betamethasone valerate; VALISONE; Betamethasone 17-valerate; (11β,16β)-9-Fluoro-11,21-dihydroxy-16-methyl-3,20-dioxopregna-1,4-dien-17-yl valerate; 9-Fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17-valerate; UNII-9IFA5XM7R2; MFCD00867446; Hormezon; Ecoval 70; Betnovate; Pentanoic acid, (11β,16β)-9-fluoro-11,21-dihydroxy-16-methyl-3,20-dioxopregna-1,4-dien-17-yl ester; β-Methasone 17-valerate; Celestoderm; EINECS 218-439-3

Molecular FormulaC27H37FO6

Molecular Weight476.578

Purity98%

Density1.2±0.1 g/cm3

Boiling Point598.9±50.0 °C at 760 mmHg

Melting Point183-184ºC

Flash Point

Appearancewhite powder

EINECS

MSDSChineseEnglish

Symbol4.3

Signal WordWarning

Cat. No.: 2A-9009383 Purity: 98%
Change View

Please Login or Create an Account to: See VlP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

Inquiry

Quality Control of [ 2152-44-5 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number2152-44-5
Catalog No.2A-9009383
Chinese Name倍他米松戊酸酯
Synonyms(11β,16β)-9-fluoro-11,21-dihydroxy-16-methyl-3,20-dioxopregna-1,4-dien-17-yl pentanoate; 9-Fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione-17-valerate; β-Methasone-17-valerate; (11b,16b)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione 17-Valerate; Betamethasone valerate; VALISONE; Betamethasone 17-valerate; (11β,16β)-9-Fluoro-11,21-dihydroxy-16-methyl-3,20-dioxopregna-1,4-dien-17-yl valerate; 9-Fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17-valerate; UNII-9IFA5XM7R2; MFCD00867446; Hormezon; Ecoval 70; Betnovate; Pentanoic acid, (11β,16β)-9-fluoro-11,21-dihydroxy-16-methyl-3,20-dioxopregna-1,4-dien-17-yl ester; β-Methasone 17-valerate; Celestoderm; EINECS 218-439-3
Molecular FormulaC27H37FO6
Molecular Weight476.578
Purity98
Density1.2±0.1 g/cm3
Boiling Point598.9±50.0 °C at 760 mmHg
Melting Point183-184ºC
Appearancewhite powder
Storage ConditionStore at 2-8°C
ApplicationBetamethasone valerate (Betamethasone 17-valerate) is the 17-valerate ester of Betamethasone, a topical corticosteroid with anti-inflammatory activity. Betamethasone valerate may be used to treat recu
HTC2932999099
SMILESCCCCC(=O)OC1(C(=O)CO)C(C)CC2C3CCC4=CC(=O)C=CC4(C)C3(F)C(O)CC21C
InChIInChI=1S/C27H37FO6/c1-5-6-7-23(33)34-27(22(32)15-29)16(2)12-20-19-9-8-17-13-18(30)10-11-24(17,3)26(19,28)21(31)14-25(20,27)4/h10-11,13,16,19-21,29,31H,5-9,12,14-15H2,1-4H3/t16-,19-,20-,21-,24-,25-,26-,27-/m0/s1
InChI KeySNHRLVCMMWUAJD-SUYDQAKGSA-N
Hazard Symbols4.3
BioactivityBetamethasone valerate (Betamethasone 17-valerate), the 17-valerate ester of Betamethasone, is a topical corticosteroid with anti-inflammatory activity. Betamethasone valerate is used in the treatment of recurrent aphthous stomatitis. Betamethasone valerate inhibits the binding of the radiolabeled glucocorticoid dexamethasone (3H dexamethasone) to human epidermis and mouse skin with IC50s of 5 and 6 nM, respectively[1][2][3]. Related Catalog Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor In Vivo Betamethasone valerate (10 mg; 5 minutes; applied to the irritated site with a micro spatula) ointment inhibits about 50% of the ear edema without thymus atrophy[4]. Betamethasone-17-valerate ointment (50 mg) inhibits homologous passive cutaneous anaphylaxis[4]. Animal Model: Female Sprague-Dawley rats weighing 60-70 g (croton oil edema experiment)[4] Dosage: 10 mg Administration: Applied to the irritated site with a micro spatula; 5 minutes Result: Inhibited about 50% of the ear edema without thymus atrophy. References [1]. Sizílio RH, et al. Chitosan/pvp-based mucoadhesive membranes as a promising delivery system of betamethasone-17-valerate for aphthous stomatitis. Carbohydr Polym. 2018 Jun 15;190:339-345. [2]. Epstein EH Jr, et al. Glucocorticoid receptors of normal human epidermis. J Invest Dermatol. 1982 Feb;78(2):144-6. [3]. WILLIAMS DI, et al. BETAMETHASONE 17-VALERATE: A NEW TOPICAL CORTICOSTEROID. Lancet. 1964 May 30;1(7344):1177-9. [4]. Iizuka Y, et al. Two simple methods for the evaluation of topically active anti-inflammatory steroidal ointments. Agents Actions. 1981 May;11(3):254-9. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 598.9±50.0 °C at 760 mmHg Melting Point 183-184ºC Molecular Formula C27H37FO6 Molecular Weight 476.578 Flash Point 316.0±30.1 °C Exact Mass 476.257416 PSA 100.90000 LogP 3.78 Vapour Pressure 0.0±3.8 mmHg at 25°C Index of Refraction 1.560 InChIKey SNHRLVCMMWUAJD-SUYDQAKGSA-N SMILES CCCCC(=O)OC1(C(=O)CO)C(C)CC2C3CCC4=CC(=O)C=CC4(C)C3(F)C(O)CC21C Storage condition 2-8°C
Use ofBetamethasone valerate (Betamethasone 17-valerate), the 17-valerate ester of Betamethasone, is a topical corticosteroid with anti-inflammatory activity. Betamethasone valerate is used in the treatment of recurrent aphthous stomatitis. Betamethasone valerate inhibits the binding of the radiolabeled glucocorticoid dexamethasone (3H dexamethasone) to human epidermis and mouse skin with IC50s of 5 and 6 nM, respectively[1][2][3]. Properties Articles27 Name betamethasone valerate Synonym More Synonyms Betamethasone 17-valerate Biological Activity Description Betamethasone valerate (Betamethasone 17-valerate), the 17-valerate ester of Betamethasone, is a topical corticosteroid with anti-inflammatory activity. Betamethasone valerate is used in the treatment of recurrent aphthous stomatitis. Betamethasone valerate inhibits the binding of the radiolabeled glucocorticoid dexamethasone (3H dexamethasone) to human epidermis and mouse skin with IC50s of 5 and 6 nM, respectively[1][2][3]. Related Catalog Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor References [1]. Sizílio RH, et al. Chitosan/pvp-based mucoadhesive membranes as a promising delivery system of betamethasone-17-valerate for aphthous stomatitis. Carbohydr Polym. 2018 Jun 15;190:339-345. [2]. Epstein EH Jr, et al. Glucocorticoid receptors of normal human epidermis. J Invest Dermatol. 1982 Feb;78(2):144-6. [3]. WILLIAMS DI, et al. BETAMETHASONE 17-VALERATE: A NEW TOPICAL CORTICOSTEROID. Lancet. 1964 May 30;1(7344):1177-9. [4]. Iizuka Y, et al. Two simple methods for the evaluation of topically active anti-inflammatory steroidal ointments. Agents Actions. 1981 May;11(3):254-9. Chemical & Physical Properties Molecular Formula C27H37FO6 Exact Mass 476.257416 PSA 100.90000 Index of Refraction 1.560 InChIKey SNHRLVCMMWUAJD-SUYDQAKGSA-N
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport InfoProduct name: Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Related Products in API & Advanced Intermediates
Benazepril86541-75-52A-9009323
Benazeprilat86541-78-82A-9009325
beta-Lumicolchicine2A-3004632A-9009380
Betamethasone butyrate propionate5534-02-12A-9009381
Betamethasone Dipropionate5593-20-42A-9009382
Bicalutamide90357-06-52A-9009396
Bisoprolol fumarate104344-23-22A-9009416
Bortezomib179324-69-72A-9009431
Buprenorphine52485-79-72A-9009493
Calcitonin,porcine12321-44-72A-9009539
Browse all API & Advanced Intermediates products »
Contact Us

Phone:

630-322-8886

630-322-8887

Email:

[email protected]

Office Locations:

Chicago, IL, USA

San Francisco, CA, USA