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Bicalutamide structure, CAS 90357-06-5

Bicalutamide

CAS Number90357-06-5

SynonymsBicaiutamide; ODEX; BicalutaMide API; MFCD00869971; R-bicalutamide; Bicalutamide; R-Bicalutimide; Cosudex

Molecular FormulaC18H14F4N2O4S

Molecular Weight430.37

Purity99%

Density1.5±0.1 g/cm3

Boiling Point650.3±55.0 °C at 760 mmHg

Melting Point191-193°C

Flash Point

AppearanceOff-white crystalline solid

EINECS

MSDSChineseEnglish

Symbol9

Signal WordWarning

Cat. No.: 2A-9009396 Purity: 99%
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Quality Control of [ 90357-06-5 ] Purity: 99% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number90357-06-5
Catalog No.2A-9009396
Chinese Name比卡鲁胺
SynonymsBicaiutamide; ODEX; BicalutaMide API; MFCD00869971; R-bicalutamide; Bicalutamide; R-Bicalutimide; Cosudex
Molecular FormulaC18H14F4N2O4S
Molecular Weight430.37
Purity99
Density1.5±0.1 g/cm3
Boiling Point650.3±55.0 °C at 760 mmHg
Melting Point191-193°C
AppearanceOff-white crystalline solid
Storage ConditionStore at RT
PackagingIII
ApplicationBicalutamide is a non-steroidal androgen receptor inhibitor.
HTC2929909090
PubChem ID329749112
MDL NumberMFCD00869971
SMILESCC(O)(CS(=O)(=O)c1ccc(F)cc1)C(=O)Nc2ccc(C#N)c(c2)C(F)(F)F
InChI1S/C18H14F4N2O4S/c1-17(26,10-29(27,28)14-6-3-12(19)4-7-14)16(25)24-13-5-2-11(9-23)15(8-13)18(20,21)22/h2-8,26H,10H2,1H3,(H,24,25)
InChI KeyLKJPYSCBVHEWIU-UHFFFAOYSA-N
NACRES CodeNA.24
UNSPSC41116107
Hazard Symbols9
MSDSmsds/9396_1_90357_06_5.pdf
BioactivityBicalutamide is a non-steroidal androgen receptor inhibitor. Related Catalog Signaling Pathways >> Others >> Androgen Receptor Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Cancer References [1]. Nicola J. Clegg,1 John Wongvipat,1,2 Jim Joseph, ARN-509: a novel anti-androgen for prostate cancer treatment. Cancer Res. 2012 March 15; 72(6): 1494-1503. [2]. RACHEL M. SQUILLACE, DAVID MILLER, SCOTT D. WARDWELL, Synergistic activity of the mTOR inhibitor ridaforolimus and the antiandrogen bicalutamide in prostate cancer models. Int J Oncol. 2012 August; 41(2): 425-432. [3]. Nakabayashi M, Werner L, Courtney KD, Phase II trial of RAD001 and bicalutamide for castration-resistant prostate cancer. BJU Int. 2012 Dec;110(11):1729-35. Chemical & Physical Properties Density 1.5±0.1 g/cm3 Boiling Point 650.3±55.0 °C at 760 mmHg Melting Point 191-193°C Molecular Formula C18H14F4N2O4S Molecular Weight 430.373 Flash Point 347.1±31.5 °C Exact Mass 430.061035 PSA 115.64000 LogP 4.94 Vapour Pressure 0.0±2.0 mmHg at 25°C Index of Refraction 1.578 InChIKey LKJPYSCBVHEWIU-UHFFFAOYSA-N SMILES CC(O)(CS(=O)(=O)c1ccc(F)cc1)C(=O)Nc1ccc(C#N)c(C(F)(F)F)c1 Storage condition Store at RT
Use ofBicalutamide is a non-steroidal androgen receptor inhibitor. Properties Articles89 Name bicalutamide Synonym More Synonyms Bicalutamide Biological Activity Description Bicalutamide is a non-steroidal androgen receptor inhibitor. Related Catalog Signaling Pathways >> Others >> Androgen Receptor Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Cancer References [1]. Nicola J. Clegg,1 John Wongvipat,1,2 Jim Joseph, ARN-509: a novel anti-androgen for prostate cancer treatment. Cancer Res. 2012 March 15; 72(6): 1494-1503. [2]. RACHEL M. SQUILLACE, DAVID MILLER, SCOTT D. WARDWELL, Synergistic activity of the mTOR inhibitor ridaforolimus and the antiandrogen bicalutamide in prostate cancer models. Int J Oncol. 2012 August; 41(2): 425-432. [3]. Nakabayashi M, Werner L, Courtney KD, Phase II trial of RAD001 and bicalutamide for castration-resistant prostate cancer. BJU Int. 2012 Dec;110(11):1729-35. Chemical & Physical Properties Molecular Formula C18H14F4N2O4S Exact Mass 430.061035 PSA 115.64000 Index of Refraction 1.578 InChIKey LKJPYSCBVHEWIU-UHFFFAOYSA-N Storage condition Store at RT
Tax Rebate9.0%
SupervisionNone MFN tariff: 6.5% Ordinary tariff: 30.0%
Transport InfoShipping Name: UN
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available
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