CAS Number138890-62-7
SynonymsMFCD08067749; Birnzolamide; Brinzolamide (BRZ); 3znc; Azopt (TN); Azopt; (4R)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-3,4-dihydrothieno[3,2-e]thiazine-6-sulfonamide; Brinzolamide [USAN]; Brinzolamide
Molecular FormulaC12H21N3O5S3
Molecular Weight383.51
Purity≥98 (HPLC)%
Density1.5±0.1 g/cm3
Boiling Point586.0±60.0 °C at 760 mmHg
Appearancepowder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 138890-62-7 |
| Catalog No. | 2A-9009440 |
| Chinese Name | 布林佐胺 |
| Synonyms | MFCD08067749; Birnzolamide; Brinzolamide (BRZ); 3znc; Azopt (TN); Azopt; (4R)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-3,4-dihydrothieno[3,2-e]thiazine-6-sulfonamide; Brinzolamide [USAN]; Brinzolamide |
| Molecular Formula | C12H21N3O5S3 |
| Molecular Weight | 383.51 |
| Purity | ≥98 (HPLC) |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 586.0±60.0 °C at 760 mmHg |
| Appearance | powder |
| Storage Condition | ?20°C |
| Application | Brinzolamide (AL 4862) is a carbonic anhydrase II inhibitor with an IC50 of 3.19 nM. |
| HTC | 2935009090 |
| PubChem ID | 329825236 |
| MDL Number | MFCD08067749 |
| SMILES | CCN[C@H]1CN(CCCOC)S(=O)(=O)c2sc(cc12)S(N)(=O)=O |
| InChI | 1S/C12H21N3O5S3/c1-3-14-10-8-15(5-4-6-20-2)23(18,19)12-9(10)7-11(21-12)22(13,16)17/h7,10,14H,3-6,8H2,1-2H3,(H2,13,16,17)/t10-/m0/s1 |
| InChI Key | HCRKCZRJWPKOAR-JTQLQIEISA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | Transport |
| MSDS | msds/9440_1_138890_62_7.pdf |
| Bioactivity | Brinzolamide(AL 4862) is a potent carbonic anhydrase II inhibitor with IC50 of 3.19 nM.Target: carbonic anhydrase IIBrinzolamide (< 1 mg) ophthalmic suspension lowers intraocular pressure in Dutch-belted pigmented rabbits in a dose-dependent manner with an onset within 0.5 hour and a peak response by 1-2 hours. Brinzolamide (0.6 mg) ophthalmic suspension lowers intraocular pressure in laser-treated glaucomatous cynomolgus monkeys in a dose-dependent manner with an onset within 1 hour and a peak response by 3 hours. Brinzolamide dosages of 30 mg/kg, produces a 44% reduction in intestinal charcoal meal progression, but 1 and 10 mg/kg produced 8% and 18% decreases, respectively, in male CD-1 mice. Brinzolamide of 1 mg/kg, 10 mg/kg, and 30 mg/kg prolongs barbiturate sleep time by 57%, 15%, and 35%, respectively, in male CD-1 mice [1]. Brinzolamide (< 3%) produces significantly greater mean percent intraocular pressure reductions and mean intraocular pressure reductions compared with placebo in patients with primary, open-angle glaucoma or ocular hypertension. The optimal intraocular pressure-lowering concentration of brinzolamide is 1%, brinzolamide 1% is well tolerated by patients with primary open-angle glaucoma or ocular hypertension when administered twice daily [2]. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Carbonic Anhydrase Research Areas >> Others References [1]. DeSantis, L., Preclinical overview of brinzolamide. Surv Ophthalmol, 2000. 44 Suppl 2: p. S119-29. [2]. Silver, L.H., Dose-response evaluation of the ocular hypotensive effect of brinzolamide ophthalmic suspension (Azopt). Brinzolamide Dose-Response Study Group. Surv Ophthalmol, 2000. 44 Suppl 2: p. S147-53. Chemical & Physical Properties Density 1.5±0.1 g/cm3 Boiling Point 586.0±60.0 °C at 760 mmHg Molecular Formula C12H21N3O5S3 Molecular Weight 383.507 Flash Point 308.2±32.9 °C Exact Mass 383.064331 PSA 163.80000 LogP -0.65 Vapour Pressure 0.0±1.6 mmHg at 25°C Index of Refraction 1.626 InChIKey HCRKCZRJWPKOAR-JTQLQIEISA-N SMILES CCNC1CN(CCCOC)S(=O)(=O)c2sc(S(N)(=O)=O)cc21 Storage condition ?20°C |
| Use of | Properties Articles39 Name brinzolamide Synonym More Synonyms Brinzolamide Biological Activity Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Carbonic Anhydrase Research Areas >> Others References [1]. DeSantis, L., Preclinical overview of brinzolamide. Surv Ophthalmol, 2000. 44 Suppl 2: p. S119-29. [2]. Silver, L.H., Dose-response evaluation of the ocular hypotensive effect of brinzolamide ophthalmic suspension (Azopt). Brinzolamide Dose-Response Study Group. Surv Ophthalmol, 2000. 44 Suppl 2: p. S147-53. Chemical & Physical Properties Molecular Formula C12H21N3O5S3 Exact Mass 383.064331 PSA 163.80000 LogP -0.65 Index of Refraction 1.626 InChIKey HCRKCZRJWPKOAR-JTQLQIEISA-N |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 35.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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