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Brimonidine structure, CAS 59803-98-4

Brimonidine

CAS Number59803-98-4

Synonymsbrimonidinum; 5-bromo-6-(imidazolin-2-ylamino)-quinoxaline; MFCD00153878; Brimonidine [INN:BAN]; Bromoxidine; Brimonidine; 5-bromo-6-(2-imidazolin-2-ylamino)quinoxaline; UNII-E6GNX3HHTE; [3H]-Brimonidine; 5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)quinoxalin-6-amine; 5-Bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-6-quinoxalinamine; UK 14,304; brimonidina

Molecular FormulaC11H10BrN5

Molecular Weight292.13

Purity98%

Density1.8±0.1 g/cm3

Boiling Point432.6±55.0 °C at 760 mmHg

Melting Point207.5 °C

Flash Point

Appearanceyellow solid

EINECS

MSDSChineseEnglish

Symbol6.1

Signal WordWarning

Cat. No.: 2A-9009437 Purity: 98%
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Quality Control of [ 59803-98-4 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number59803-98-4
Catalog No.2A-9009437
Chinese Name溴莫尼定
Synonymsbrimonidinum; 5-bromo-6-(imidazolin-2-ylamino)-quinoxaline; MFCD00153878; Brimonidine [INN:BAN]; Bromoxidine; Brimonidine; 5-bromo-6-(2-imidazolin-2-ylamino)quinoxaline; UNII-E6GNX3HHTE; [3H]-Brimonidine; 5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)quinoxalin-6-amine; 5-Bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-6-quinoxalinamine; UK 14,304; brimonidina
Molecular FormulaC11H10BrN5
Molecular Weight292.13
Purity98
Density1.8±0.1 g/cm3
Boiling Point432.6±55.0 °C at 760 mmHg
Melting Point207.5 °C
Appearanceyellow solid
Water Solubility45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: <0.8
Storage ConditionStore in a sealed container in a cool, dry place
PackagingIII
ApplicationBrimonidine (UK 14304) is a full α2-adrenoceptor agonist.
HTC2934999090
PubChem ID24277812
MDL NumberMFCD00153878
SMILESBrc1c(NC2=NCCN2)ccc3nccnc13
InChI1S/C11H10BrN5/c12-9-7(17-11-15-5-6-16-11)1-2-8-10(9)14-4-3-13-8/h1-4H,5-6H2,(H2,15,16,17)
InChI KeyXYLJNLCSTIOKRM-UHFFFAOYSA-N
NACRES CodeNA.77
UNSPSC12352200
Hazard Symbols6.1
MSDSmsds/9437_1_59803_98_4.pdf
BioactivityBrimonidine (UK 14304) is a full α2-adrenergic receptor (α2-AR) agonist. Related Catalog Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Others Target α2-adrenergic Receptor. In Vitro [3H]Brimonidine (UK 14304) is a full agonist at alpha 2-adrenergic receptors. [3H]Brimonidine (UK 14304) labels at least 2 specific binding sites in human brain that both have the characteristics of an alpha 2-adrenergic binding site. GTP decreases agonist binding at both of these sites, but with different potencies at each site [1-3]. References [1]. Andorn, A.C., M.A. Carlson, and R.C. Gilkeson, Specific [3H]UK 14,304 binding in human cortex occurs at multiple high affinity states with alpha 2-adrenergic selectivity and differing affinities for GTP. Life Sci, 1988. 43(22): p. 1805-12. [2]. Cambridge, D., UK-14,304, a potent and selective alpha2-agonist for the characterisation of alpha-adrenoceptor subtypes. Eur J Pharmacol, 1981. 72(4): p. 413-5. [3]. Chopin, P., F.C. Colpaert, and M. Marien, Effects of alpha-2 adrenoceptor agonists and antagonists on circling behavior in rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal pathway. J Pharmacol Exp Ther, 1999. 288(2): p. 798-804. Chemical & Physical Properties Density 1.8±0.1 g/cm3 Boiling Point 432.6±55.0 °C at 760 mmHg Melting Point 207.5 °C Molecular Formula C11H10BrN5 Molecular Weight 292.135 Flash Point 215.4±31.5 °C Exact Mass 291.011963 PSA 62.20000 LogP 0.96 Vapour Pressure 0.0±1.0 mmHg at 25°C Index of Refraction 1.798 InChIKey XYLJNLCSTIOKRM-UHFFFAOYSA-N SMILES Brc1c(NC2=NCCN2)ccc2nccnc12 Storage condition Store at RT Water Solubility 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: <0.8 mg/mL
Use ofBrimonidine (UK 14304) is a full α2-adrenergic receptor (α2-AR) agonist. Properties Articles55 Name brimonidine Synonym More Synonyms Brimonidine Biological Activity Description Brimonidine (UK 14304) is a full α2-adrenergic receptor (α2-AR) agonist. Related Catalog Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Others α2-adrenergic Receptor. In Vitro [3H]Brimonidine (UK 14304) is a full agonist at alpha 2-adrenergic receptors. [3H]Brimonidine (UK 14304) labels at least 2 specific binding sites in human brain that both have the characteristics of an alpha 2-adrenergic binding site. GTP decreases agonist binding at both of these sites, but with different potencies at each site [1-3]. References [1]. Andorn, A.C., M.A. Carlson, and R.C. Gilkeson, Specific [3H]UK 14,304 binding in human cortex occurs at multiple high affinity states with alpha 2-adrenergic selectivity and differing affinities for GTP. Life Sci, 1988. 43(22): p. 1805-12. [2]. Cambridge, D., UK-14,304, a potent and selective alpha2-agonist for the characterisation of alpha-adrenoceptor subtypes. Eur J Pharmacol, 1981. 72(4): p. 413-5. [3]. Chopin, P., F.C. Colpaert, and M. Marien, Effects of alpha-2 adrenoceptor agonists and antagonists on circling behavior in rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal pathway. J Pharmacol Exp Ther, 1999. 288(2): p. 798-804. Chemical & Physical Properties Molecular Formula C11H10BrN5 Exact Mass 291.011963 PSA 62.20000 Index of Refraction 1.798 InChIKey XYLJNLCSTIOKRM-UHFFFAOYSA-N Storage condition Store at RT
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport InfoShipping Name: UN
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Dangerous Regulations for land transport: 2811 International Dangerous Regulations for sea transport: 2811 International Dangerous Regulations for air transport: 2811 14.2 United Nations shipping name European Land Transport Dangerous Regulations: TOXIC SOLID, ORGANIC, N.O.S. (6-Quinoxalinamine, 5-bromo-N-(4,5-dihydro-1H- imidazol-2-yl)-) IMDG: TOXIC SOLID, ORGANIC, N.O.S. (6-Quinoxalinamine, 5-bromo-N-(4,5-dihydro-1H- imidazol-2-yl)-) International air transport hazard regulations: Toxic solid, organic, n.o.s. (6-Quinoxalinamine, 5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available
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