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Brimonidinne tartrate structure, CAS 70359-46-5

Brimonidinne tartrate

CAS Number70359-46-5

SynonymsBrimonidine tartrate; 5-Bromo-N-(4,5-dihydro-1H-imidazol-2-yl) quinoxalin-6-amine tartrate; 5-Bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-6-quinoxalinamine L-tartrate; 5-Bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-6-quinoxalinamine, (2R,3R)-2,3-dihydroxybutanedioate; MFCD07773086; UK 14,304 (tartrate)

Molecular FormulaC15H16BrN5O6

Molecular Weight442.22

Purity98%

Density

Boiling Point432.6ºC at 760 mmHg

Melting Point207-208ºC (dec.)

Flash Point

AppearanceCream-light yellow powder

EINECS

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Cat. No.: 2A-9009438 Purity: 98%
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Quality Control of [ 70359-46-5 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number70359-46-5
Catalog No.2A-9009438
Chinese Name酒石酸溴莫尼定
SynonymsBrimonidine tartrate; 5-Bromo-N-(4,5-dihydro-1H-imidazol-2-yl) quinoxalin-6-amine tartrate; 5-Bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-6-quinoxalinamine L-tartrate; 5-Bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-6-quinoxalinamine, (2R,3R)-2,3-dihydroxybutanedioate; MFCD07773086; UK 14,304 (tartrate)
Molecular FormulaC15H16BrN5O6
Molecular Weight442.22
Purity98
Boiling Point432.6ºC at 760 mmHg
Melting Point207-208ºC (dec.)
AppearanceCream-light yellow powder
Storage Condition-20°C Freezer
ApplicationUK 14,304 is an _alpha_2-adrenergic receptor (_alpha_2-AR) receptor agonist.
HTC2933990090
SMILESBrc1c2nccnc2ccc1NC3=NCCN3.O[C@H]([C@@H](O)C(=O)O)C(=O)O
InChI1S/C11H10BrN5.C4H6O6/c12-9-7(17-11-15-5-6-16-11)1-2-8-10(9)14-4-3-13-8;5-1(3(7)8)2(6)4(9)10/h1-4H,5-6H2,(H2,15,16,17);1-2,5-6H,(H,7,8)(H,9,10)/t;1-,2-/m.1/s1
InChI KeyQZHBYNSSDLTCRG-LREBCSMRSA-N
NACRES CodeNA.24
UNSPSC41116107
MSDSmsds/9438_1_70359_46_5.pdf
BioactivityUK 14,304 is a full α2-adrenergic receptor (α2-AR) agonist.Target: α2-adrenergic Receptor[3H]UK 14,034 is a full agonist at alpha 2-adrenergic receptors. [3H]UK 14,304 labels at least 2 specific binding sites in human brain that both have the characteristics of an alpha 2-adrenergic binding site. GTP decreases agonist binding at both of these sites, but with different potencies at each site [1-3]. Related Catalog Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Others References [1]. Andorn, A.C., M.A. Carlson, and R.C. Gilkeson, Specific [3H]UK 14,304 binding in human cortex occurs at multiple high affinity states with alpha 2-adrenergic selectivity and differing affinities for GTP. Life Sci, 1988. 43(22): p. 1805-12. [2]. Cambridge, D., UK-14,304, a potent and selective alpha2-agonist for the characterisation of alpha-adrenoceptor subtypes. Eur J Pharmacol, 1981. 72(4): p. 413-5. [3]. Chopin, P., F.C. Colpaert, and M. Marien, Effects of alpha-2 adrenoceptor agonists and antagonists on circling behavior in rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal pathway. J Pharmacol Exp Ther, 1999. 288(2): p. 798-804. Chemical & Physical Properties Boiling Point 432.6ºC at 760 mmHg Melting Point 207-208ºC (dec.) Molecular Formula C15H16BrN5O6 Molecular Weight 442.221 Flash Point 215.4ºC Exact Mass 441.028381 PSA 177.26000 InChIKey QZHBYNSSDLTCRG-LREBCSMRSA-N SMILES Brc1c(NC2=NCCN2)ccc2nccnc12.O=C(O)C(O)C(O)C(=O)O Storage condition -20°C Freezer
Use ofProperties Articles33 Name 5-Bromo-N-(4,5-Dihydro-1H-Imidazol-2-yl)-6-Quinoxalinamine Tartrate Synonym More Synonyms Brimonidine L-tartrate Biological Activity Related Catalog Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Others References [1]. Andorn, A.C., M.A. Carlson, and R.C. Gilkeson, Specific [3H]UK 14,304 binding in human cortex occurs at multiple high affinity states with alpha 2-adrenergic selectivity and differing affinities for GTP. Life Sci, 1988. 43(22): p. 1805-12. [2]. Cambridge, D., UK-14,304, a potent and selective alpha2-agonist for the characterisation of alpha-adrenoceptor subtypes. Eur J Pharmacol, 1981. 72(4): p. 413-5. [3]. Chopin, P., F.C. Colpaert, and M. Marien, Effects of alpha-2 adrenoceptor agonists and antagonists on circling behavior in rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal pathway. J Pharmacol Exp Ther, 1999. 288(2): p. 798-804. Chemical & Physical Properties Molecular Formula C15H16BrN5O6 Exact Mass 441.028381 PSA 177.26000 InChIKey QZHBYNSSDLTCRG-LREBCSMRSA-N
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport InfoProduct name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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