CAS Number69304-47-8
Synonyms5-[(E)-2-bromoethenyl]-2'-deoxyuridine; Brivudine; BrVDU; Bromovinyldeoxyuridine; MFCD00058585; 5-[(E)-2-Bromovinyl]-2'-deoxyuridine; Zostrex; BVDU; (E)-5-(2-Bromovinyl)-2'-deoxyuridine; BVDR
Molecular FormulaC11H13BrN2O5
Molecular Weight333.14
Purity≥95%
Density1.9±0.1 g/cm3
Boiling Point382.9ºC at 760 mmHg
Melting Point165ºC
AppearanceSolid;White to Almost white powder to crystal
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 69304-47-8 |
| Catalog No. | 2A-9009441 |
| Chinese Name | 溴夫定 |
| Synonyms | 5-[(E)-2-bromoethenyl]-2'-deoxyuridine; Brivudine; BrVDU; Bromovinyldeoxyuridine; MFCD00058585; 5-[(E)-2-Bromovinyl]-2'-deoxyuridine; Zostrex; BVDU; (E)-5-(2-Bromovinyl)-2'-deoxyuridine; BVDR |
| Molecular Formula | C11H13BrN2O5 |
| Molecular Weight | 333.14 |
| Purity | ≥95 |
| Density | 1.9±0.1 g/cm3 |
| Boiling Point | 382.9ºC at 760 mmHg |
| Melting Point | 165ºC |
| Appearance | Solid;White to Almost white powder to crystal |
| Water Solubility | Soluble in water and methanol. |
| Storage Condition | Store in a sealed container in a cool, dry place. |
| Application | Brivudine is a thymidine analog with antiviral activity used to treat early-stage acute herpes zoster. |
| MDL Number | MFCD00058585 |
| SMILES | O=C(C(/C=C/Br)=CN1[C@H]2C[C@H](O)[C@@H](CO)O2)NC1=O |
| InChI | 1S/C11H13BrN2O5/c12-2-1-6-4-14(11(18)13-10(6)17)9-3-7(16)8(5-15)19-9/h1-2,4,7-9,15-16H,3,5H2,(H,13,17,18)/b2-1+/t7-,8+,9+/m0/s1 |
| InChI Key | ODZBBRURCPAEIQ-PIXDULNESA-N |
| NACRES Code | NA.21 |
| UNSPSC | 51101500 |
| Hazard Symbols | Transport |
| MSDS | msds/9441_1_69304_47_8.pdf |
| Bioactivity | Brivudine is a thymidine analogue with antiviral activity, indicated for the early treatment of acute herpes zoster. Related Catalog Signaling Pathways >> Anti-infection >> CMV Research Areas >> Infection In Vitro Brivudine is an analog of thymidine, and is incorporated into the viral DNA. It blocks the action of DNA polymerases, thus inhibiting viral replication. It has a stronger antiviral effect against the varicella-zoster virus compared with reference compounds such as aciclovir or penciclovir[1]. It has high, selective activity against varicella zoster virus (VZV), inhibiting VZV replication, possibly through competitive inhibition of viral DNA polymerase, or by acting as an alternative substrate to deoxythymidine triphosphate, causing viral DNA strand breakage[2]. In Vivo At a dose of 125 mg once daily, brivudine has proved to be superior to aciclovir with respect to reducing the period of new blister production, and has shortened the duration of post-herpetic neuralgia[1]. References [1]. Rabasseda X, et al. Brivudine: a herpes virostatic with rapid antiviral activity and once-daily dosing. Drugs Today (Barc). 2003 May;39(5):359-71. [2]. Keam SJ, et al. Brivudin (bromovinyl deoxyuridine). Drugs. 2004;64(18):2091-7; discussion 2098-9. Chemical & Physical Properties Density 1.9±0.1 g/cm3 Boiling Point 382.9ºC at 760 mmHg Melting Point 165ºC Molecular Formula C11H13BrN2O5 Molecular Weight 333.135 Flash Point 185.4ºC Exact Mass 332.000763 PSA 104.55000 LogP -0.80 Index of Refraction 1.709 InChIKey ODZBBRURCPAEIQ-PIXDULNESA-N SMILES O=c1[nH]c(=O)n(C2CC(O)C(CO)O2)cc1C=CBr Water Solubility Soluble in water and methanol. |
| Use of | Brivudine is a thymidine analogue with antiviral activity, indicated for the early treatment of acute herpes zoster. Properties Articles27 Name Brivudine Synonym More Synonyms Brivudine Biological Activity Description Brivudine is a thymidine analogue with antiviral activity, indicated for the early treatment of acute herpes zoster. Related Catalog Signaling Pathways >> Anti-infection >> CMV Research Areas >> Infection In Vitro Brivudine is an analog of thymidine, and is incorporated into the viral DNA. It blocks the action of DNA polymerases, thus inhibiting viral replication. It has a stronger antiviral effect against the varicella-zoster virus compared with reference compounds such as aciclovir or penciclovir[1]. It has high, selective activity against varicella zoster virus (VZV), inhibiting VZV replication, possibly through competitive inhibition of viral DNA polymerase, or by acting as an alternative substrate to deoxythymidine triphosphate, causing viral DNA strand breakage[2]. References [1]. Rabasseda X, et al. Brivudine: a herpes virostatic with rapid antiviral activity and once-daily dosing. Drugs Today (Barc). 2003 May;39(5):359-71. [2]. Keam SJ, et al. Brivudin (bromovinyl deoxyuridine). Drugs. 2004;64(18):2091-7; discussion 2098-9. Chemical & Physical Properties Molecular Formula C11H13BrN2O5 Exact Mass 332.000763 PSA 104.55000 LogP -0.80 Index of Refraction 1.709 InChIKey ODZBBRURCPAEIQ-PIXDULNESA-N Water Solubility Soluble in water and methanol. |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available See reverse side of invoice or packing slip. |
| Related Products in Specialty Chemicals | ||
|---|---|---|
| Brilliant green | 633-03-4 | 2A-9009436 |
| Brimonidine | 59803-98-4 | 2A-9009437 |
| Brimonidinne tartrate | 70359-46-5 | 2A-9009438 |
| Brinazarone | 89622-90-2 | 2A-9009439 |
| Brinzolamide | 138890-62-7 | 2A-9009440 |
| Broadleaf Liriope Root | 2A-300525 | 2A-9009442 |
| Brocrinat | 72481-99-3 | 2A-9009443 |
| Bromacil | 314-40-9 | 2A-9009445 |
| Bromchlorenone | 5579-85-1 | 2A-9009447 |
| Bromerguride | 83455-48-5 | 2A-9009448 |
| Browse all Specialty Chemicals products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS