CAS Number71963-77-4
SynonymsArteMos; Artesaph; Dihydroqinghaosu Methyl Ether; Gvither; Artesian; Larither; Falcidol; SM-224; Paluther; ArtenaM; Artemether; MFCD00866205; MalarteM
Molecular FormulaC16H26O5
Molecular Weight298.37
Purity≥98 (HPLC)%
Density1.2±0.1 g/cm3
Boiling Point357.5±42.0 °C at 760 mmHg
Melting Point86-89ºC
Appearancepowder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 71963-77-4 |
| Catalog No. | 2A-9009242 |
| Chinese Name | 蒿甲醚 |
| Synonyms | ArteMos; Artesaph; Dihydroqinghaosu Methyl Ether; Gvither; Artesian; Larither; Falcidol; SM-224; Paluther; ArtenaM; Artemether; MFCD00866205; MalarteM |
| Molecular Formula | C16H26O5 |
| Molecular Weight | 298.37 |
| Purity | ≥98 (HPLC) |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 357.5±42.0 °C at 760 mmHg |
| Melting Point | 86-89ºC |
| Appearance | powder |
| Storage Condition | Ventilated low-temperature drying |
| Application | Artemether is an anti-malarial compound that can act on drug-resistant strains of falciparum malaria. |
| HTC | 2932999099 |
| PubChem ID | 329771050 |
| MDL Number | MFCD00866205 |
| SMILES | CO[C@H]1OC2O[C@@]3(C)CCC4[C@H](C)CCC([C@H]1C)[C@@]24OO3 |
| InChI | 1S/C16H26O5/c1-9-5-6-12-10(2)13(17-4)18-14-16(12)11(9)7-8-15(3,19-14)20-21-16/h9-14H,5-8H2,1-4H3/t9-,10-,11+,12+,13+,14-,15-,16-/m1/s1 |
| InChI Key | SXYIRMFQILZOAM-HVNFFKDJSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 51101908 |
| Hazard Symbols | Transport |
| MSDS | msds/9242_1_71963_77_4.pdf |
| Bioactivity | Artemether is an antimalarial for the treatment of resistant strains of falciparum malaria.Target: AntiparasiticArtemether is an antimalarial agent used to treat acute uncomplicated malaria. It is administered in combination with lumefantrine for improved efficacy. Artemether exhibits the highest activity against juvenile stages of the parasites, while adult worms are significantly less susceptible. There was no indication of neurotoxicity following repeated high doses of artemether given fortnightly for up to 5 months. Artemether-integrated with other control strategies-has considerable potential for reducing the current burden of schistosomiasis in different epidemiological settings [1]. There were remarkably inhibitory effects of artmeter on brain glioma growth and angiogenesis in SD rats and the mechanism that artemether inhibited brain glioma growth might be penetrating the blood-brain barrier and inhibiting angiogenesis [2]. Related Catalog Signaling Pathways >> Anti-infection >> Parasite Research Areas >> Infection Natural Products >> Terpenoids and Glycosides References [1]. Xiao, S., et al., Recent investigations of artemether, a novel agent for the prevention of schistosomiasis japonica, mansoni and haematobia. Acta Trop, 2002. 82(2): p. 175-81. [2]. Wu, Z.P., et al., Inhibitive effect of artemether on tumor growth and angiogenesis in the rat C6 orthotopic brain gliomas model. Integr Cancer Ther, 2009. 8(1): p. 88-92. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 357.5±42.0 °C at 760 mmHg Melting Point 86-89ºC Molecular Formula C16H26O5 Molecular Weight 298.375 Flash Point 140.5±27.8 °C Exact Mass 298.178009 PSA 46.15000 LogP 3.07 Vapour Pressure 0.0±0.8 mmHg at 25°C Index of Refraction 1.518 InChIKey SXYIRMFQILZOAM-OVYOIAOHSA-N SMILES COC1OC2OC3(C)CCC4C(C)CCC(C1C)C24OO3 |
| Use of | Properties Articles62 Name artemether Synonym More Synonyms Artemether Biological Activity Related Catalog Signaling Pathways >> Anti-infection >> Parasite Research Areas >> Infection Natural Products >> Terpenoids and Glycosides References [1]. Xiao, S., et al., Recent investigations of artemether, a novel agent for the prevention of schistosomiasis japonica, mansoni and haematobia. Acta Trop, 2002. 82(2): p. 175-81. [2]. Wu, Z.P., et al., Inhibitive effect of artemether on tumor growth and angiogenesis in the rat C6 orthotopic brain gliomas model. Integr Cancer Ther, 2009. 8(1): p. 88-92. Chemical & Physical Properties Molecular Formula C16H26O5 Exact Mass 298.178009 PSA 46.15000 Index of Refraction 1.518 InChIKey SXYIRMFQILZOAM-OVYOIAOHSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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