EN
0
Home > Products > Natural Products & Standards > Botanical Reference Standards > Aristolochic acid
Aristolochic acid structure, CAS 313-67-7

Aristolochic acid

CAS Number313-67-7

SynonymsAristolohic Acid A; Descresept; 8-methoxy-3,4-methylenedioxy-10-nitrophenanthrene-1-carboxylic acid; Aristolochic acid; birthwort; AristolochicacidI; EINECS 206-238-3; Aristolochia; tardolyt; Aristolochic Acid A; Aristolochia A; aristolochin; 8-Methoxy-6-nitrophenanthro[3,4-d][1,3]dioxole-5-carboxylic acid; TR 1736; Aristolochic; MFCD00004996; aristolochine; 8-Methoxy-6-nitrophenanthro[3,4-d]-1,3-dioxole-5-carboxylic Acid

Molecular FormulaC17H11NO7

Molecular Weight341.27

Purity≥90 (HPLC)%

Density1.6±0.1 g/cm3

Boiling Point615.5±55.0 °C at 760 mmHg

Melting Point269-270 °C

Flash Point

Appearancepowder

EINECS206-238-3

MSDSChineseEnglish

Symbol6.1(b)

Signal WordWarning

Cat. No.: 2A-9009235 Purity: ≥90 (HPLC)%
Change View

Please Login or Create an Account to: See VlP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

Inquiry

Quality Control of [ 313-67-7 ] Purity: ≥90 (HPLC)% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number313-67-7
Catalog No.2A-9009235
Chinese Name马兜铃酸A
SynonymsAristolohic Acid A; Descresept; 8-methoxy-3,4-methylenedioxy-10-nitrophenanthrene-1-carboxylic acid; Aristolochic acid; birthwort; AristolochicacidI; EINECS 206-238-3; Aristolochia; tardolyt; Aristolochic Acid A; Aristolochia A; aristolochin; 8-Methoxy-6-nitrophenanthro[3,4-d][1,3]dioxole-5-carboxylic acid; TR 1736; Aristolochic; MFCD00004996; aristolochine; 8-Methoxy-6-nitrophenanthro[3,4-d]-1,3-dioxole-5-carboxylic Acid
Molecular FormulaC17H11NO7
Molecular Weight341.27
Purity≥90 (HPLC)
Density1.6±0.1 g/cm3
Boiling Point615.5±55.0 °C at 760 mmHg
Melting Point269-270 °C
Appearancepowder
Water SolubilityDMSO: soluble
Storage ConditionStore at 2-8℃.
PackagingIII
ApplicationAristolochic acid A (Aristolochic acid I) is the main component of the plant extract Aristolochic acids, which is found in the herbs Aristolochia and Asarum. Aristolochic acid A significantly reduces
EINECS206-238-3
PubChem ID24890982
MDL NumberMFCD00004996
SMILESCOc1cccc2c1cc([N+]([O-])=O)c3c(cc4OCOc4c23)C(O)=O
InChI1S/C17H11NO7/c1-23-12-4-2-3-8-9(12)5-11(18(21)22)14-10(17(19)20)6-13-16(15(8)14)25-7-24-13/h2-6H,7H2,1H3,(H,19,20)
InChI KeyBBFQZRXNYIEMAW-UHFFFAOYSA-N
NACRES CodeNA.77
UNSPSC41106300
Hazard Symbols6.1(b)
MSDSmsds/9235_1_313_67_7.pdf
BioactivityAristolochic acid A (Aristolochic acid I) is the main component of plant extract Aristolochic acids, which are found in various herbal plants of genus Aristolochia and Asarum. AAI significantly reduces both activator protein 1 (AP-1) and NF-κB activities. Aristolochic acid A reduces BLCAP gene expression in human cell lines[1]. Related Catalog Research Areas >> Cancer In Vitro Aristolochic acid A (150, 200 μM, 24 hours) inhibits the cell viabilities of kidney cells HEK293 and HK-2[1]. Aristolochic acid A (100, 200 μM, 24 hours) causes a concentration-dependent decrease in bladder cancer-associated protein (BLCAP) mRNA levels in kidney cells (HEK 293 and HK-2) , and bladder cancer cell line (HT-1376)[1]. Aristolochic acid A (100, 200 μM, 24 hours) weakens the BLCAP protein signals in a dose-dependent manner in both HEK293 and HT-1376 cells[1]. Cell Viability Assay[1] Cell Line: Kidney cells (HEK 293 and HK-2) Concentration: 50, 100, 150, 200 μM Incubation Time: 24 hours Result: The cell viabilities of HEK293 and HK-2 were lower than that of vehicle-treated cultures until 150 μM and 200 μM. RT-PCR[1] Cell Line: Kidney cells (HEK 293 and HK-2), and bladder cancer cell line (HT-1376) Concentration: 100, 200 μM Incubation Time: 24 hours Result: Down regulated the levels of BLCAP mRNA. Western Blot Analysis[1] Cell Line: HEK293 and HT-1376 cells Concentration: 100, 200 μM Incubation Time: 24 hours Result: Reduced the BLCAP protein expression in a dose-dependent manner. References [1]. Huang YT, et al. Aristolochic acid I interferes with the expression of BLCAP tumor suppressor gene in human cells. Toxicol Lett. 2018 Jul;291:129-137. Chemical & Physical Properties Density 1.6±0.1 g/cm3 Boiling Point 615.5±55.0 °C at 760 mmHg Melting Point 260 °C Molecular Formula C17H11NO7 Molecular Weight 341.27 Flash Point 326.0±31.5 °C Exact Mass 341.053558 PSA 110.81000 LogP 3.41 Vapour Pressure 0.0±1.9 mmHg at 25°C Index of Refraction 1.747 Water Solubility DMSO: soluble
Use ofAristolochic acid A (Aristolochic acid I) is the main component of plant extract Aristolochic acids, which are found in various herbal plants of genus Aristolochia and Asarum. AAI significantly reduces both activator protein 1 (AP-1) and NF-κB activities. Aristolochic acid A reduces BLCAP gene expression in human cell lines[1]. Properties Articles39 Name aristolochic acid Synonym More Synonyms Aristolochic acid A Biological Activity Description Aristolochic acid A (Aristolochic acid I) is the main component of plant extract Aristolochic acids, which are found in various herbal plants of genus Aristolochia and Asarum. AAI significantly reduces both activator protein 1 (AP-1) and NF-κB activities. Aristolochic acid A reduces BLCAP gene expression in human cell lines[1]. Related Catalog Research Areas >> Cancer References [1]. Huang YT, et al. Aristolochic acid I interferes with the expression of BLCAP tumor suppressor gene in human cells. Toxicol Lett. 2018 Jul;291:129-137. Chemical & Physical Properties Molecular Formula C17H11NO7 Exact Mass 341.053558 PSA 110.81000 Index of Refraction 1.747 Water Solubility DMSO: soluble
Transport InfoShipping Name: UN
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Danger Regulations: 1544 International Maritime Transport Danger Regulations: 1544 International Air Transport Danger Regulations: 1544 14.2 United Nations shipping name European Land Transport Dangerous Regulations: ALKALOIDS, SOLID, N.O.S. (8-Methoxy-3,4-methylenedioxy-10-nitrophenanthrene-1- carboxylic acid) IMDG Code: ALKALOIDS, SOLID, N.O.S. (8-Methoxy-3,4-methylenedioxy-10-nitrophenanthrene-1- carboxylic acid) International air transport hazard regulations: Alkaloids, solid, n.o.s. (8-Methoxy-3,4-methylenedioxy-10-nitrophenanthrene-1-carboxylic acid) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available
Related Products in Botanical Reference Standards
Actein18642-44-92A-9009058
Agnuside11027-63-72A-9009080
Aloenin38412-46-32A-9009120
Panax Ginseng extract50647-08-02A-9009147
Andrographolide5508-58-72A-9009198
Artemether71963-77-42A-9009242
Artesunate88495-63-02A-9009243
Asiatic Acid464-92-62A-9009245
Asiaticoside16830-15-22A-9009246
Astragalin480-10-42A-9009253
Browse all Botanical Reference Standards products »
Contact Us

Phone:

630-322-8886

630-322-8887

Email:

[email protected]

Office Locations:

Chicago, IL, USA

San Francisco, CA, USA