CAS Number1617-53-4
Synonymsamentoflavone; Didemethyl-ginkgetin; MFCD00017470; Didemethylginkgetin; Tridemethylsciadopitysin
Molecular FormulaC30H18O10
Molecular Weight538.46
Purity≥98.0 (HPLC)%
Density1.7±0.1 g/cm3
Boiling Point910.5±65.0 °C at 760 mmHg
Melting Point>300ºC
Appearancesolid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 1617-53-4 |
| Catalog No. | 2A-9009146 |
| Chinese Name | 穗花杉双黄酮； 阿曼托黄酮 |
| Synonyms | amentoflavone; Didemethyl-ginkgetin; MFCD00017470; Didemethylginkgetin; Tridemethylsciadopitysin |
| Molecular Formula | C30H18O10 |
| Molecular Weight | 538.46 |
| Purity | ≥98.0 (HPLC) |
| Density | 1.7±0.1 g/cm3 |
| Boiling Point | 910.5±65.0 °C at 760 mmHg |
| Melting Point | >300ºC |
| Appearance | solid |
| Storage Condition | 2-8°C |
| Application | Amentoflavone is a natural flavonoid compound with many biological activities, including anti-inflammatory, antioxidant, neuroprotective and other effects. |
| PubChem ID | 57650005 |
| MDL Number | MFCD00017470 |
| SMILES | Oc1ccc(cc1)C2=CC(=O)c3c(O)cc(O)c(c3O2)-c4cc(ccc4O)C5=CC(=O)c6c(O)cc(O)cc6O5 |
| InChI | 1S/C30H18O10/c31-15-4-1-13(2-5-15)24-12-23(38)29-21(36)10-20(35)27(30(29)40-24)17-7-14(3-6-18(17)33)25-11-22(37)28-19(34)8-16(32)9-26(28)39-25/h1-12,31-36H |
| InChI Key | YUSWMAULDXZHPY-UHFFFAOYSA-N |
| Beilstein/REAXYS | 380244 |
| NACRES Code | NA.47 |
| UNSPSC | 12352200 |
| MSDS | msds/9146_1_1617_53_4.pdf |
| Bioactivity | Amentoflavone is a natural biflavone compound with many biological properties, including anti-inflammatory, antioxidative, and neuroprotective effects.IC50 value:Target:In vitro: In irradiated v79 cells, Pretreatment with amentoflavone 24 hours prior to 8 Gy 60Co γ-ray irradiation significantly inhibited apoptosis, promoted the G2 phase, decreased the concentration of ROS and mitochondrial mass [2]. Amentoflavone dose-dependently inhibited the viability of SW480 cells, and a high concentration of amentoflavone (150 μmol/L) obviously induced apoptosis of the cells [3]. In vivo: In epilepsy models, amentoflavone effectively prevented pilocarpine-induced epilepsy in a mouse kindling model, suppressed nuclear factor-κB activation and expression, inhibited excessive discharge of hippocampal neurons resulting in a reduction in epileptic seizures, shortened attack time, and diminished loss and apoptosis of hippocampal neurons [1]. Related Catalog Signaling Pathways >> Others >> Others Natural Products >> Flavonoids Research Areas >> Others References [1]. Zhang Z, et al. Amentoflavone protects hippocampal neurons: anti-inflammatory, antioxidative, and antiapoptotic effects. Neural Regen Res. 2015 Jul;10(7):1125-33. [2]. Xu P, et al. Amentoflavone acts as a radioprotector for irradiated v79 cells by regulating reactive oxygen species (ROS), cell cycle and mitochondrial mass. Asian Pac J Cancer Prev. 2014;15(18):7521-6. [3]. Yang Y, et al. [Amentoflavone induces apoptosis in SW480 human colorectal cancer cells via regulating β-catenin and caspase-3 expressions]. Nan Fang Yi Ke Da Xue Xue Bao. 2014 Jun;34(7):1035-8. Chemical & Physical Properties Density 1.7±0.1 g/cm3 Boiling Point 910.5±65.0 °C at 760 mmHg Melting Point >300ºC Molecular Formula C30H18O10 Molecular Weight 538.458 Flash Point 308.5±27.8 °C Exact Mass 538.090027 PSA 181.80000 LogP 3.11 Vapour Pressure 0.0±0.3 mmHg at 25°C Index of Refraction 1.793 InChIKey YUSWMAULDXZHPY-UHFFFAOYSA-N SMILES O=c1cc(-c2ccc(O)c(-c3c(O)cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c2)oc2cc(O)cc(O)c12 Storage condition 2-8°C |
| Use of | Properties Articles37 Name amentoflavone Synonym More Synonyms amentoflavone Biological Activity Related Catalog Signaling Pathways >> Others >> Others Natural Products >> Flavonoids Research Areas >> Others References [1]. Zhang Z, et al. Amentoflavone protects hippocampal neurons: anti-inflammatory, antioxidative, and antiapoptotic effects. Neural Regen Res. 2015 Jul;10(7):1125-33. [3]. Yang Y, et al. [Amentoflavone induces apoptosis in SW480 human colorectal cancer cells via regulating β-catenin and caspase-3 expressions]. Nan Fang Yi Ke Da Xue Xue Bao. 2014 Jun;34(7):1035-8. Chemical & Physical Properties Molecular Formula C30H18O10 Exact Mass 538.090027 PSA 181.80000 Index of Refraction 1.793 InChIKey YUSWMAULDXZHPY-UHFFFAOYSA-N |
| Transport Info | Product name: Suihuashan biflavonoids |
| Related Products in Specialty Chemicals | ||
|---|---|---|
| Alverine citrate | 5560-59-8 | 2A-9009140 |
| Amafolone | 50588-47-1 | 2A-9009141 |
| Amastatin hydrochloride | 100938-10-1 | 2A-9009142 |
| Ambroxol hydrochloride | 23828-92-4 | 2A-9009143 |
| Ambroxol hydrochlorideï¼EP2001/CP2000ï¼ | 15942-05-9 | 2A-9009144 |
| Ametryn | 834-12-8 | 2A-9009148 |
| Amezinium methyl sulfate | 30578-37-1 | 2A-9009149 |
| Amfebutamone | 34911-55-2 | 2A-9009150 |
| Amfenac sodium | 61618-27-7 | 2A-9009151 |
| Amidosulfuron | 120923-37-7 | 2A-9009152 |
| Browse all Specialty Chemicals products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS