CAS Number5560-59-8
SynonymsN-ethyl-3-phenyl-N-(3-phenylpropyl)propan-1-amine,2-hydroxypropane-1,2,3-tricarboxylic acid; MFCD00035086; EINECS 226-929-3; Alverine Citrate; Alverine (citrate)
Molecular FormulaC26H35NO7
Molecular Weight473.56
Purity98%
Boiling Point358.8ºC at 760mmHg
Appearancecrystalline powder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 5560-59-8 |
| Catalog No. | 2A-9009140 |
| Chinese Name | 枸橼酸阿尔维林 |
| Synonyms | N-ethyl-3-phenyl-N-(3-phenylpropyl)propan-1-amine,2-hydroxypropane-1,2,3-tricarboxylic acid; MFCD00035086; EINECS 226-929-3; Alverine Citrate; Alverine (citrate) |
| Molecular Formula | C26H35NO7 |
| Molecular Weight | 473.56 |
| Purity | 98 |
| Boiling Point | 358.8ºC at 760mmHg |
| Appearance | crystalline powder |
| Storage Condition | -20°C |
| Application | Alverine citrate is an antagonist of the 5-HT1A receptor with an IC50 value of 101 nM. |
| HTC | 2921499090 |
| MDL Number | MFCD00035086 |
| SMILES | OC(=O)CC(O)(CC(O)=O)C(O)=O.CCN(CCCc1ccccc1)CCCc2ccccc2 |
| InChI | 1S/C20H27N.C6H8O7/c1-2-21(17-9-15-19-11-5-3-6-12-19)18-10-16-20-13-7-4-8-14-20;7-3(8)1-6(13,5(11)12)2-4(9)10/h3-8,11-14H,2,9-10,15-18H2,1H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12) |
| InChI Key | RYHCACJBKCOBTJ-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | Transport |
| MSDS | msds/9140_1_5560_59_8.pdf |
| Bioactivity | Alverine citrate is a 5-HT1A receptor antagonist, with an IC50 of 101 nM. Related Catalog Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor Research Areas >> Metabolic Disease Target 5-HT1A Receptor:101 nM (IC50) In Vitro Alverine is a drug used for functional gastrointestinal disorders. Alverine acts directly on the muscle in the gut, causing it to relax. Alverine Citrate (20 mg/kg) suppresses the effect of 5-HTP, but not that of 8-OH-DPAT. However, when injected intracerebroventricularly (75 μg/rat) alverine citrate reduces 8-OH-DPAT-induced enhancement of rectal distension-induced abdominal contractions. In-vitro binding studies reveal that Alverine citrate has a high affinity for 5-HT1A receptors and a weak affinity for 5-HT3 and 5-HT4 subtypes[1]. Alverine may increase Ca influx during action potentials due to inhibition of the inactivation of L-type Ca channels, but may also suppress evoked activity by inhibiting the sensitivity of contractile proteins to Ca2+[2]. References [1]. Coelho, A.M., et al., Rectal antinociceptive properties of alverine citrate are linked to antagonism at the 5-HT1A receptor subtype. J Pharm Pharmacol, 2001. 53(10): p. 1419-26. [2]. Hayase, M., et al., Evolving mechanisms of action of alverine citrate on phasic smooth muscles. Br J Pharmacol, 2007. 152(8): p. 1228-38. Chemical & Physical Properties Boiling Point 358.8ºC at 760mmHg Molecular Formula C26H35NO7 Molecular Weight 473.55900 Flash Point 174.4ºC Exact Mass 473.24100 PSA 135.37000 LogP 3.32540 InChIKey RYHCACJBKCOBTJ-UHFFFAOYSA-N SMILES CCN(CCCc1ccccc1)CCCc1ccccc1.O=C(O)CC(O)(CC(=O)O)C(=O)O Storage condition -20°C |
| Use of | Alverine citrate is a 5-HT1A receptor antagonist, with an IC50 of 101 nM. Properties Articles17 Name alverine citrate Synonym More Synonyms Alverine citrate Biological Activity Description Alverine citrate is a 5-HT1A receptor antagonist, with an IC50 of 101 nM. Related Catalog Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor Research Areas >> Metabolic Disease 5-HT1A Receptor:101 nM (IC50) References [1]. Coelho, A.M., et al., Rectal antinociceptive properties of alverine citrate are linked to antagonism at the 5-HT1A receptor subtype. J Pharm Pharmacol, 2001. 53(10): p. 1419-26. [2]. Hayase, M., et al., Evolving mechanisms of action of alverine citrate on phasic smooth muscles. Br J Pharmacol, 2007. 152(8): p. 1228-38. Chemical & Physical Properties Molecular Formula C26H35NO7 Exact Mass 473.24100 PSA 135.37000 LogP 3.32540 InChIKey RYHCACJBKCOBTJ-UHFFFAOYSA-N |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 30.0% |
| Transport Info | Product name: Purity: 99.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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