CAS Number645-05-6
SynonymsHTM; Hexastat; 2,4,6-tris<dimethylamino>-1,3,5-triazine; HMM; N2,N2,N4,N4,N6,N6-hexamethyl-1,3,5-triazine-2,4,6-triamine; Hexalen; EINECS 211-428-4; N,N,N',N',N″,N″-hexamethyl-1,3,5-triazine-2,4,6-triamine; N,N,N',N',N'',N''-Hexamethyl-1,3,5-triazine-2,4,6-triamine; hexamethylmelamine; Altretamine; Hexylen; MFCD00549245; N,N,N,N,N,N-Hexamethyl-1,3,5-triazine-2,4,6-triamine; NC 195; hemel
Molecular FormulaC9H18N6
Molecular Weight210.28
Purity96%
Density1.1±0.1 g/cm3
Boiling Point339.4±25.0 °C at 760 mmHg
Melting Point171-175 °C (lit.)
Appearancecolorless crystalline solid
EINECS211-428-4
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 645-05-6 |
| Catalog No. | 2A-9009138 |
| Chinese Name | 2,4,6-三(二甲氨基)均三嗪 |
| Synonyms | HTM; Hexastat; 2,4,6-tris<dimethylamino>-1,3,5-triazine; HMM; N2,N2,N4,N4,N6,N6-hexamethyl-1,3,5-triazine-2,4,6-triamine; Hexalen; EINECS 211-428-4; N,N,N',N',N″,N″-hexamethyl-1,3,5-triazine-2,4,6-triamine; N,N,N',N',N'',N''-Hexamethyl-1,3,5-triazine-2,4,6-triamine; hexamethylmelamine; Altretamine; Hexylen; MFCD00549245; N,N,N,N,N,N-Hexamethyl-1,3,5-triazine-2,4,6-triamine; NC 195; hemel |
| Molecular Formula | C9H18N6 |
| Molecular Weight | 210.28 |
| Purity | 96 |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 339.4±25.0 °C at 760 mmHg |
| Melting Point | 171-175 °C (lit.) |
| Appearance | colorless crystalline solid |
| Water Solubility | Insoluble |
| Storage Condition | Normal temperature, 2-8℃, avoid light, ventilated |
| Application | Altretamine is an alkylating agent with anti-tumor activity. |
| EINECS | 211-428-4 |
| HTC | 2933699090 |
| PubChem ID | 24874728 |
| MDL Number | MFCD00549245 |
| SMILES | CN(C)c1nc(nc(n1)N(C)C)N(C)C |
| InChI | 1S/C9H18N6/c1-13(2)7-10-8(14(3)4)12-9(11-7)15(5)6/h1-6H3 |
| InChI Key | UUVWYPNAQBNQJQ-UHFFFAOYSA-N |
| NACRES Code | NA.22 |
| UNSPSC | 12352100 |
| MSDS | msds/9138_1_645_05_6.pdf |
| Use of | Altretamine is an alkylating antineoplastic agent. Properties Articles34 Name hexamethylmelamine Synonym More Synonyms Altretamine Biological Activity Description Altretamine is an alkylating antineoplastic agent. Related Catalog Signaling Pathways >> Cell Cycle/DNA Damage >> DNA Alkylator/Crosslinker Research Areas >> Cancer In Vitro Altretamine is an antineoplastic agent[1]. References Chemical & Physical Properties Molecular Formula C9H18N6 Exact Mass 210.159302 PSA 48.39000 Index of Refraction 1.610 InChIKey UUVWYPNAQBNQJQ-UHFFFAOYSA-N SMILES CN(C)c1nc(N(C)C)nc(N(C)C)n1 Storage condition Refrigerator Water Solubility Insoluble Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Melamine, hexamethyl- CAS REGISTRY NUMBER : BEILSTEIN REFERENCE NO. : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : MOLECULAR WEIGHT : WISWESSER LINE NOTATION : T6N CN ENJ BN1&1 DN1&1 FN1&1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : DOSE/DURATION : TOXIC EFFECTS : Gastrointestinal - nausea or vomiting Blood - leukopenia TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - chromodacryorrhea Blood - hemorrhage TYPE OF TEST : LD10 - Lethal Dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Blood - granulocytopenia Blood - changes in bone marrow (not otherwise specified) TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Cardiac - cardiomyopathy including infarction Liver - hepatitis (hepatocellular necrosis), zonal TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : TOXIC EFFECTS : Blood - pigmented or nucleated red blood cells Blood - changes in leukocyte (WBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Bird - chicken DOSE/DURATION : TOXIC EFFECTS : Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - ataxia TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Related to Chronic Data - death TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Related to Chronic Data - death TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : TOXIC EFFECTS : Blood - changes in bone marrow (not otherwise specified) Blood - other changes Related to Chronic Data - death TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Human - woman DOSE/DURATION : TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Blood - leukemia TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Tumorigenic - neoplastic by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors Skin and Appendages - tumors TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SEX/DURATION : male 62 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females) Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SEX/DURATION : female 6-9 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SEX/DURATION : female 9-12 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SEX/DURATION : female 15-22 day(s) after conception lactating female 21 day(s) post-birth TOXIC EFFECTS : Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive) Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SEX/DURATION : female 15-22 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SEX/DURATION : female 6-18 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) TYPE OF TEST : Sex chromosome loss and nondisjunction TYPE OF TEST : Cytogenetic analysis MUTATION DATA TYPE OF TEST : DNA damage TEST SYSTEM : Mammal - species unspecified Lymphocyte DOSE/DURATION : 250 umol/L REFERENCE : Safety Information Signal Word Warning Hazard Statements H302-H315-H319-H335 Precautionary Statements P261-P305 + P351 + P338 Personal Protective Equipment dust mask type N95 (US);Eyeshields;Faceshields;Gloves Hazard Codes Xn: Harmful; Safety Phrases S26-S36 RIDADR NONH for all modes of transport WGK Germany 3 RTECS OS1050000 HS Code 2933699090 Precursor & DownStream Precursor 7 CAS#:1467-79-4 Cyanamide,N,N-d... CAS#:108-77-0 Cyanuric chloride CAS#:124-40-3 Dimethylamine CAS#:123-39-7 N-methylformamide DownStream 2 CAS#:124-40-3 Dimethylamine CAS#:108-80-5 Tricyanic acid |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933699090 other compounds containing an unfused triazine ring (whether or not hydrogenated) in the structure. Supervision conditions:None. VAT: 17.0%. Tax rebate rate:9.0%. MFN tariff: 6.5%. General tariff:20.0% |
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