EN
0
Home > Products > Specialty & Industrial Chemicals > Specialty Chemicals > Ambroxol hydrochloride
Ambroxol hydrochloride structure, CAS 23828-92-4

Ambroxol hydrochloride

CAS Number23828-92-4

SynonymsAntobron; trans-4-[(2-Amino-3,5-dibromobenzyl)amino]cyclohexanol hydrochloride; Ambron; DURAMUCAL; trans-4-[(2-Amino-3,5-dibromobenzyl)amino]cyclohexanol hydrochloride (1:1); mucolear; trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride; trans-4-[(2-Amino-3,5-dibromobenzyl)amino]cyclohexanol chlorhydrate; MFCD00078932; FLUIXOL; cis-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride; Cyclohexanol, 4-[[(2-amino-3,5-dibromophenyl)methyl]amino]-, trans-, hydrochloride (1:1); ABRAMEN; trans-4-(((2-Amino-3,5-dibromophenyl)methyl)amino)cyclohexan-1-ol hydrochloride; 2-Amino-3,5-dibromo-N-(trans-4-hydroxycyclohexyl)benzylamine; trans-4-[(2-Amino-3,5-dibrombenzyl)amino]cyclohexanolhydrochlorid; NA 872 hydrochloride; AMBRIL; Ambroxol HCl; EINECS 245-899-2; BLUIBRON; Anki

Molecular FormulaC13H19Br2ClN2O

Molecular Weight414.56

Purity98%

Density

Boiling Point468.6ºC at 760 mmHg

Melting Point235 - 240ºC

Flash Point

AppearanceWhite to light yellow crystalline powder

EINECS

MSDSChineseEnglish

Symbol

Signal Word

Cat. No.: 2A-9009143 Purity: 98%
Change View

Please Login or Create an Account to: See VlP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

Inquiry

Quality Control of [ 23828-92-4 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number23828-92-4
Catalog No.2A-9009143
Chinese Name盐酸氨溴索
SynonymsAntobron; trans-4-[(2-Amino-3,5-dibromobenzyl)amino]cyclohexanol hydrochloride; Ambron; DURAMUCAL; trans-4-[(2-Amino-3,5-dibromobenzyl)amino]cyclohexanol hydrochloride (1:1); mucolear; trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride; trans-4-[(2-Amino-3,5-dibromobenzyl)amino]cyclohexanol chlorhydrate; MFCD00078932; FLUIXOL; cis-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride; Cyclohexanol, 4-[[(2-amino-3,5-dibromophenyl)methyl]amino]-, trans-, hydrochloride (1:1); ABRAMEN; trans-4-(((2-Amino-3,5-dibromophenyl)methyl)amino)cyclohexan-1-ol hydrochloride; 2-Amino-3,5-dibromo-N-(trans-4-hydroxycyclohexyl)benzylamine; trans-4-[(2-Amino-3,5-dibrombenzyl)amino]cyclohexanolhydrochlorid; NA 872 hydrochloride; AMBRIL; Ambroxol HCl; EINECS 245-899-2; BLUIBRON; Anki
Molecular FormulaC13H19Br2ClN2O
Molecular Weight414.56
Purity98
Boiling Point468.6ºC at 760 mmHg
Melting Point235 - 240ºC
AppearanceWhite to light yellow crystalline powder
Storage ConditionWarehouse Ventilation Low Temperature Drying
ApplicationAmbroxol hydrochloride (NA-872 hydrochloride) is the active metabolite of the prodrug bromhexine and has a strong expectorant effect. Ambroxol hydrochloride is a glucocerebrosidase (GCase) chaperone t
HTC2922199090
MDL NumberMFCD00078932
SMILESCl.Nc1c(Br)cc(Br)cc1CN[C@@H]2CC[C@@H](O)CC2
InChI1S/C13H18Br2N2O.ClH/c14-9-5-8(13(16)12(15)6-9)7-17-10-1-3-11(18)4-2-10;/h5-6,10-11,17-18H,1-4,7,16H2;1H/t10-,11-;
InChI KeyQNVKOSLOVOTXKF-PFWPSKEQSA-N
NACRES CodeNA.24
UNSPSC41116107
MSDSmsds/9143_1_23828_92_4.pdf
BioactivityAmbroxol hydrochloride (NA-872 hydrochloride), an active metabolite of the prodrug Bromhexine, has potent expectorant effects. Ambroxol hydrochloride is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol hydrochloride induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research[1][2]. Related Catalog Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Metabolic Disease Research Areas >> Neurological Disease In Vivo Ambroxol hydrochloride (NA-872 hydrochloride; 1, 3, 4, 5 mM for 12 consecutive days in drinking water) results in increased brain glucocerebrosidase activity in wild-type mice, transgenic mice expressing the heterozygous L444P mutation in the murine glucocerebrosidase 1 gene, and transgenic mice overexpressing human α-synuclein[2]. References [1]. Vojo Deretic, et al. Enhancement of lung levels of antibiotics by ambroxol and bromhexine. Expert Opin Drug Metab Toxicol. 2019 Mar;15(3):213-218. [2]. Anna Migdalska-Richards, et al. Ambroxol effects in glucocerebrosidase and α-synuclein transgenic mice. Ann Neurol. 2016 Nov;80(5):766-775. Chemical & Physical Properties Boiling Point 468.6ºC at 760 mmHg Melting Point 235 - 240ºC Molecular Formula C13H19Br2ClN2O Molecular Weight 414.564 Flash Point 237.2ºC Exact Mass 411.955261 PSA 58.28000 LogP 4.96100
Use ofAmbroxol hydrochloride (NA-872 hydrochloride), an active metabolite of the prodrug Bromhexine, has potent expectorant effects. Ambroxol hydrochloride is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol hydrochloride induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research[1][2]. Properties Name Ambroxol hydrochloride Synonym More Synonyms Ambroxol HCl Biological Activity Description Ambroxol hydrochloride (NA-872 hydrochloride), an active metabolite of the prodrug Bromhexine, has potent expectorant effects. Ambroxol hydrochloride is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol hydrochloride induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research[1][2]. Related Catalog Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Metabolic Disease Research Areas >> Neurological Disease References [1]. Vojo Deretic, et al. Enhancement of lung levels of antibiotics by ambroxol and bromhexine. Expert Opin Drug Metab Toxicol. 2019 Mar;15(3):213-218. [2]. Anna Migdalska-Richards, et al. Ambroxol effects in glucocerebrosidase and α-synuclein transgenic mice. Ann Neurol. 2016 Nov;80(5):766-775. Chemical & Physical Properties Exact Mass 411.955261 PSA 58.28000 LogP 4.96100
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 30.0%
Transport InfoProduct name: Summary 2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
Related Products in Specialty Chemicals
Altretamine645-05-62A-9009138
Aluminum nicotinate1976-28-92A-9009139
Alverine citrate5560-59-82A-9009140
Amafolone50588-47-12A-9009141
Amastatin hydrochloride100938-10-12A-9009142
Ambroxol hydrochloride（EP2001/CP2000）15942-05-92A-9009144
Amentoflavone1617-53-42A-9009146
Ametryn834-12-82A-9009148
Amezinium methyl sulfate30578-37-12A-9009149
Amfebutamone34911-55-22A-9009150
Browse all Specialty Chemicals products »
Contact Us

Phone:

630-322-8886

630-322-8887

Email:

[email protected]

Office Locations:

Chicago, IL, USA

San Francisco, CA, USA