CAS Number30578-37-1
SynonymsSupratonin; Amezinio metilsulfato [Spanish]; Amezinii metilsulfas [INN-Latin]; Regulton; Ameziniummetilsulfat [German]; amexinium methyl sulfate; Metilsulfate d'amezinium [INN-French]; 4-amino-6-methoxy-1-phenyl-pyridazinium methyl sulfate; Amezinium Methyl Sulfate; EINECS 250-248-0; Amezinium methylsulfate; amezinium metilsulfate
Molecular FormulaC12H15O5N3S1
Molecular Weight313.33
Purity99%
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 30578-37-1 |
| Catalog No. | 2A-9009149 |
| Chinese Name | 甲磺美嗪 |
| Synonyms | Supratonin; Amezinio metilsulfato [Spanish]; Amezinii metilsulfas [INN-Latin]; Regulton; Ameziniummetilsulfat [German]; amexinium methyl sulfate; Metilsulfate d'amezinium [INN-French]; 4-amino-6-methoxy-1-phenyl-pyridazinium methyl sulfate; Amezinium Methyl Sulfate; EINECS 250-248-0; Amezinium methylsulfate; amezinium metilsulfate |
| Molecular Formula | C12H15O5N3S1 |
| Molecular Weight | 313.33 |
| Purity | 99 |
| Storage Condition | Room temperature, dry |
| Application | Amezinium metilsulfate stimulates alpha and beta-1 receptors and inhibits norepinephrine and tyramine absorption. |
| HTC | 2933990090 |
| MDL Number | MFCD00865972 |
| SMILES | COS(=O)(=O)[O-].COc1cc(N)cn[n+]1-c1ccccc1 |
| InChI | InChI=1S/C11H11N3O.CH4O4S/c1-15-11-7-9(12)8-13-14(11)10-5-3-2-4-6-10;1-5-6(2,3)4/h2-8,12H,1H3;1H3,(H,2,3,4) |
| InChI Key | ZEASXVYVFFXULL-UHFFFAOYSA-N |
| MSDS | msds/9149_1_30578_37_1.pdf |
| Bioactivity | Amezinium metilsulfate has multiple mechanisms, including stimulation of alpha and beta-1 receptors and inhibition ofnoradrenaline and tyramine uptake. Target: alpha and beta-1 receptorsAmezinium metilsulfate is a sympathomimetic drug used for the treatment of low blood pressure. Cardiovascular effects of the new sympathomimetic Amezinium metilsulphate are investigated in 25 patients compared with a control group (n = 25). During spinal/epidural anaesthesia 5 mg amezinium is given i.v. if blood pressure dropped greater than 20 mmHg. from starting-point. A significant recovery of blood pressure (epidural anaesthesia: syst 21%, diast 9%; spinal anaesthesia: syst 13%, diast 6.6%) and a decrease in heart rate (6.8% resp. 4,5%) are thought due to peripheral vasoconstriction. Amezinium proves a stimulating drug for alpha- and beta 1-receptors by stabilising the systemic blood pressure in spinal/epidural anaesthesia. Related Catalog Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Cardiovascular Disease References [1]. Schaps D, et al. Therapeutic use of amezinium methylsulfate--a new, long acting, sympathomimetic--in paraspinal conduction anesthesia. Anasth Intensivther Notfallmed. 1984 Oct;19(5):235-9. Chemical & Physical Properties Molecular Formula C12H15N3O5S Molecular Weight 313.33000 Exact Mass 313.07300 PSA 126.83000 LogP 1.70410 InChIKey ZEASXVYVFFXULL-UHFFFAOYSA-N SMILES COS(=O)(=O)[O-].COc1cc(N)cn[n+]1-c1ccccc1 |
| Use of | Properties Name 6-methoxy-1-phenylpyridazin-1-ium-4-amine,methyl sulfate Synonym More Synonyms Amezinium methylsulfate Biological Activity Related Catalog Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Cardiovascular Disease References [1]. Schaps D, et al. Therapeutic use of amezinium methylsulfate--a new, long acting, sympathomimetic--in paraspinal conduction anesthesia. Anasth Intensivther Notfallmed. 1984 Oct;19(5):235-9. Chemical & Physical Properties Molecular Formula C12H15N3O5S Exact Mass 313.07300 PSA 126.83000 LogP 1.70410 InChIKey ZEASXVYVFFXULL-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified Mesalmethine Modification Number: 5 |
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