CAS Number61618-27-7
SynonymsSodium (2-amino-3-benzoylphenyl)acetate hydrate (1:1:1); Amfenac sodium salt monohydrate; 2-Amino-3-benzoylbenzeneacetic acid,monosodium salt,monohydrate; 2-Amino-3-benzoylbenzeneacetic acid sodium salt hydrate; sodium,2-(2-amino-3-benzoylphenyl)acetate,hydrate; Benzeneacetic acid, 2-amino-3-benzoyl-, sodium salt, hydrate (1:1:1); AHR-5850D; Amfenac Sodium Hydrate; Amfenac sodium monohydrate; Fenazox; Amfenac sodium salt hydrate
Molecular FormulaC15H14NNaO4
Molecular Weight295.266
Purity98.00%
Boiling Point520ºC at 760 mmHg
Melting Point242-244ºC
Appearanceyellow solid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 61618-27-7 |
| Catalog No. | 2A-9009151 |
| Chinese Name | 氨芬酸钠 |
| Synonyms | Sodium (2-amino-3-benzoylphenyl)acetate hydrate (1:1:1); Amfenac sodium salt monohydrate; 2-Amino-3-benzoylbenzeneacetic acid,monosodium salt,monohydrate; 2-Amino-3-benzoylbenzeneacetic acid sodium salt hydrate; sodium,2-(2-amino-3-benzoylphenyl)acetate,hydrate; Benzeneacetic acid, 2-amino-3-benzoyl-, sodium salt, hydrate (1:1:1); AHR-5850D; Amfenac Sodium Hydrate; Amfenac sodium monohydrate; Fenazox; Amfenac sodium salt hydrate |
| Molecular Formula | C15H14NNaO4 |
| Molecular Weight | 295.266 |
| Purity | 98.00 |
| Boiling Point | 520ºC at 760 mmHg |
| Melting Point | 242-244ºC |
| Appearance | yellow solid |
| Storage Condition | Refrigerator |
| Application | Amfenac Sodium Hydrate is a COX-2 inhibitor. |
| HTC | 2922509090 |
| SMILES | Nc1c(CC(=O)[O-])cccc1C(=O)c1ccccc1.O.[Na+] |
| InChI | InChI=1S/C15H13NO3.Na.H2O/c16-14-11(9-13(17)18)7-4-8-12(14)15(19)10-5-2-1-3-6-10;;/h1-8H,9,16H2,(H,17,18);;1H2/q;+1;/p-1 |
| InChI Key | QZNJPJDUBTYMRS-UHFFFAOYSA-M |
| Use of | Amfenac Sodium Hydrate is a COX-2 inhibitor. Properties Name amfenac sodium hydrate Synonym More Synonyms Amfenac Sodium Monohydrate Biological Activity Description Amfenac Sodium Hydrate is a COX-2 inhibitor. Related Catalog Research Areas >> Inflammation/Immunology Cell Assay Human uveal melanoma cell lines are transfected to constitutively express COX-2 and the proliferative rate of these cells using two different methods, with and without the addition of Amfenac Sodium Hydrate, is measured. Nitric oxide production by macrophages is measured after exposure to melanoma-conditioned medium from both groups of cells as well as with and without Amfenac Sodium Hydrate[1]. References [1]. Marshall JC, et al. The effects of a cyclooxygenase-2 (COX-2) expression and inhibition on human uveal melanoma cell proliferation and macrophage nitric oxide production. J Carcinog. 2007 Nov 27;6:17. [2]. Matsumoto T, et al. Effect of a non-steroidal anti-inflammatory drug (amfenac sodium) on polymorphonuclear leukocytes. Pharmacol Res Commun. 1982 Jun;14(6):523-32. Chemical & Physical Properties Molecular Formula C15H14NNaO4 Exact Mass 295.082062 PSA 92.45000 LogP 1.30910 InChIKey QZNJPJDUBTYMRS-UHFFFAOYSA-M Storage condition Refrigerator Safety Information Hazard Codes Xi HS Code 2922509090 |
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