CAS Number4345-03-3
Synonymsa-Tocopheryl Succinate; a-Tocopheryl Acid Succinate; α-Tocopheryl acid succinate; (+)-α-Tocopheryl succinate; VES; EINECS 224-403-8; D-α-Tocopherol succinate; (+)-2,5,7,8-Tetramethyl-2-(4,8,12-trimethyltridecyl)-6-chromanyl Hydrogen Succinate; a-Tocopherol Acid Succinate; d-alpha-Tocopherol succinate(E); a-Tocopheryl Hydrogen Succinate; a-Tocopherol Hemisuccinate; Vitamin E Succinate; MFCD00072055; Covitol 1210; (+)-a-Tocopheryl Succinate
Molecular FormulaC33H54O5
Molecular Weight530.78
Purity98%
Density1.0±0.1 g/cm3
Boiling Point625.8±55.0 °C at 760 mmHg
Melting Point~76 °C(lit.)
Appearancepowder
EINECS224-403-8
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 4345-03-3 |
| Catalog No. | 2A-9008908 |
| Chinese Name | 维生素E琥珀酸酯 |
| Synonyms | a-Tocopheryl Succinate; a-Tocopheryl Acid Succinate; α-Tocopheryl acid succinate; (+)-α-Tocopheryl succinate; VES; EINECS 224-403-8; D-α-Tocopherol succinate; (+)-2,5,7,8-Tetramethyl-2-(4,8,12-trimethyltridecyl)-6-chromanyl Hydrogen Succinate; a-Tocopherol Acid Succinate; d-alpha-Tocopherol succinate(E); a-Tocopheryl Hydrogen Succinate; a-Tocopherol Hemisuccinate; Vitamin E Succinate; MFCD00072055; Covitol 1210; (+)-a-Tocopheryl Succinate |
| Molecular Formula | C33H54O5 |
| Molecular Weight | 530.78 |
| Purity | 98 |
| Density | 1.0±0.1 g/cm3 |
| Boiling Point | 625.8±55.0 °C at 760 mmHg |
| Melting Point | ~76 °C(lit.) |
| Appearance | powder |
| Storage Condition | Store at room temperature, away from light, in a v |
| Application | D-alpha-tocopheryl succinate (vitamin E succinate) is a salt form of the antioxidant tocopherol and vitamin E. D-α-Tocopherol succinic acid inhibits cisplatin (HY-17394)-induced cytotoxicity. D-alpha- |
| EINECS | 224-403-8 |
| HTC | 2936.28.0000 |
| PubChem ID | 24900107 |
| MDL Number | MFCD00072055 |
| SMILES | CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC[C@]1(C)CCc2c(C)c(OC(=O)CCC(O)=O)c(C)c(C)c2O1 |
| InChI | 1S/C33H54O5/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-20-33(8)21-19-28-27(7)31(25(5)26(6)32(28)38-33)37-30(36)18-17-29(34)35/h22-24H,9-21H2,1-8H3,(H,34,35)/t23-,24-,33-/m1/s1 |
| InChI Key | IELOKBJPULMYRW-NJQVLOCASA-N |
| Beilstein/REAXYS | 4038233 |
| NACRES Code | NA.28 |
| eCl@ss | 34058016 |
| UNSPSC | 12352205 |
| Hazard Symbols | Transport |
| MSDS | msds/8908_1_4345_03_3.pdf |
| Bioactivity | D-α-Tocopherol Succinate (Vitamin E succinate) is an antioxidant tocopherol and a salt form of vitamin E. D-α-Tocopherol Succinate inhibits Cisplatin (HY-17394)-induced cytotoxicity. D-α-Tocopherol Succinate can be used for the research of cancer[1][2]. Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer In Vitro D-α-Tocopherol Succinate (1-20 μM; 24 hours) shows cytotoxicity to HEI-OC1 cells[1]. D-α-Tocopherol Succinate (10 μM; 48 hours) protects HEI-OC1 cells against cisplatin-induced ototoxicity and inhibits caspase-3 activity[1]. D-α-Tocopherol Succinate (0-50 μM; 18 hours) shows cytotoxicity to TC-1 tumor cells[2]. Cell Cytotoxicity Assay[1] Cell Line: HEI-OC1 cell line Concentration: 1-20 μM Incubation Time: 24 hours Result: Significantly induced cytotoxicity at a concentration of 20 μM and showed a higher cytotoxicity potency compared with 10 μM. Cell Viability Assay[1] Cell Line: HEI-OC1 cell line Concentration: 10 μM Incubation Time: 48 hours Result: Increased cisplatin-induced cell population. Inhibited cisplatin-induced necrotic, ROS production and late apoptosis. Decreased cleaved PARP and inhibited the expression of caspase-3 which related to cisplatin-induced apoptosis. Cell Cytotoxicity Assay[2] Cell Line: TC-1 tumor cells Concentration: 0, 25 and 50 μM Incubation Time: 18 hours Result: Dose-dependently showed cytotoxic and induced a higher percentage of necrotic TC-1 cells as opposed to apoptotic cells. In Vivo D-α-Tocopherol Succinate (1-2 mg/kg; i.p. three times at 2 day intervals from TC-1 tumor cells injection for 10 days to 14 days) shows antitumor effects to mice with TC-1 tumor[2]. Animal Model: Six- to eight-week-old female C57BL/6 mice with TC-1 tumor cells[2] Dosage: 1 and 2 mg/kg Administration: Intraperitoneal injection; 1 and 2 mg/kg three times at 2 day intervals; from TC-1 tumor cells injection for 10 days to 14 days Result: Dreased the tumor volume, especially with a dose of 2 mg/kg. References [1]. Kim SK, et al. The effects of the antioxidant α-tocopherol succinate on cisplatin-induced ototoxicity in HEI-OC1 auditory cells. Int J Pediatr Otorhinolaryngol. 2016 Jul;86:9-14. [2]. Kang TH, et al. Treatment of tumors with vitamin E suppresses myeloid derived suppressor cells and enhances CD8+ T cell-mediated antitumor effects. PLoS One. 2014 Jul 29;9(7):e103562. Chemical & Physical Properties Density 1.0±0.1 g/cm3 Boiling Point 625.8±55.0 °C at 760 mmHg Melting Point ~76 °C(lit.) Molecular Formula C33H54O5 Molecular Weight 530.779 Flash Point 187.0±25.0 °C Exact Mass 530.397095 PSA 72.83000 LogP 11.88 Vapour Pressure 0.0±1.9 mmHg at 25°C Index of Refraction 1.498 InChIKey IELOKBJPULMYRW-NJQVLOCASA-N SMILES Cc1c(C)c2c(c(C)c1OC(=O)CCC(=O)O)CCC(C)(CCCC(C)CCCC(C)CCCC(C)C)O2 Storage condition 2-8°C |
| Use of | D-α-Tocopherol Succinate (Vitamin E succinate) is an antioxidant tocopherol and a salt form of vitamin E. D-α-Tocopherol Succinate inhibits Cisplatin (HY-17394)-induced cytotoxicity. D-α-Tocopherol Succinate can be used for the research of cancer[1][2]. Properties Articles14 Name α-Tocopheryl Succinate Synonym More Synonyms VES Biological Activity Description D-α-Tocopherol Succinate (Vitamin E succinate) is an antioxidant tocopherol and a salt form of vitamin E. D-α-Tocopherol Succinate inhibits Cisplatin (HY-17394)-induced cytotoxicity. D-α-Tocopherol Succinate can be used for the research of cancer[1][2]. Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer References [1]. Kim SK, et al. The effects of the antioxidant α-tocopherol succinate on cisplatin-induced ototoxicity in HEI-OC1 auditory cells. Int J Pediatr Otorhinolaryngol. 2016 Jul;86:9-14. [2]. Kang TH, et al. Treatment of tumors with vitamin E suppresses myeloid derived suppressor cells and enhances CD8+ T cell-mediated antitumor effects. PLoS One. 2014 Jul 29;9(7):e103562. Chemical & Physical Properties Molecular Formula C33H54O5 Exact Mass 530.397095 PSA 72.83000 LogP 11.88 Index of Refraction 1.498 InChIKey IELOKBJPULMYRW-NJQVLOCASA-N |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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