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Prednisolone sodium phosphate structure, CAS 125-02-0

Prednisolone sodium phosphate

CAS Number125-02-0

Synonyms(11beta); Phortisolone; Inflamase; prednisolon disodium phosphate; Prednisolone sodium phosphate; Optival; Predsol; 11b,17,21-Trihydroxypregna-1,4-diene-3,20-dione 21-(Disodium phosphate); Codelsol; Prednisolone (disodium phosphate); prednisolone 21-disodium phosphate; Prednisolone 21-Phosphate Disodium Salt; MFCD07776968; 11β,17,21-Trihydroxypregna-1,4-diene-3,20-dione 21-(disodium phosphate); METRETON; Prozorin; Disodium Prednisolone 21-Phosphate; EINECS 204-722-9; Solucort; Predsolan; Prednesol; Dojilon; Pregna-1,4-diene-3,20-dione, 11,17-dihydroxy-21-(phosphonooxy)-, sodium salt, (11β)- (1:2); Disodium (11β)-11,17-dihydroxy-3,20-dioxopregna-1,4-dien-21-yl phosphate; Ak-pred

Molecular FormulaC21H27Na2O8P

Molecular Weight484.39

Purity96%

Density

Boiling Point100 °C

Melting Point

Flash Point

Appearancesolid

EINECS204-722-9

MSDSChineseEnglish

Symbol

Signal Word

Cat. No.: 2A-9008691 Purity: 96%
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Quality Control of [ 125-02-0 ] Purity: 96% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number125-02-0
Catalog No.2A-9008691
Chinese Name泼尼松龙21-磷酸二钠
Synonyms(11beta); Phortisolone; Inflamase; prednisolon disodium phosphate; Prednisolone sodium phosphate; Optival; Predsol; 11b,17,21-Trihydroxypregna-1,4-diene-3,20-dione 21-(Disodium phosphate); Codelsol; Prednisolone (disodium phosphate); prednisolone 21-disodium phosphate; Prednisolone 21-Phosphate Disodium Salt; MFCD07776968; 11β,17,21-Trihydroxypregna-1,4-diene-3,20-dione 21-(disodium phosphate); METRETON; Prozorin; Disodium Prednisolone 21-Phosphate; EINECS 204-722-9; Solucort; Predsolan; Prednesol; Dojilon; Pregna-1,4-diene-3,20-dione, 11,17-dihydroxy-21-(phosphonooxy)-, sodium salt, (11β)- (1:2); Disodium (11β)-11,17-dihydroxy-3,20-dioxopregna-1,4-dien-21-yl phosphate; Ak-pred
Molecular FormulaC21H27Na2O8P
Molecular Weight484.39
Purity96
Boiling Point100 °C
Appearancesolid
Storage ConditionRoom Temperature
ApplicationPrednisolone disodium phosphate is a synthetic glucocorticoid with anti-inflammatory and immunomodulatory activities.
EINECS204-722-9
HTC2937229000
SMILES[Na+].[Na+].[P](=O)([O-])([O-])OCC(=O)C1(C2(C(C3C(C4(C(=CC(=O)C=C4)CC3)C)C(C2)O)CC1)C)O
InChI1S/C21H29O8P.2Na/c1-19-7-5-13(22)9-12(19)3-4-14-15-6-8-21(25,17(24)11-29-30(26,27)28)20(15,2)10-16(23)18(14)19;;/h5,7,9,14-16,18,23,25H,3-4,6,8,10-11H2,1-2H3,(H2,26,27,28);;/q;2*+1/p-2
InChI KeyVJZLQIPZNBPASX-UHFFFAOYSA-L
NACRES CodeNA.24
UNSPSC41116107
MSDSmsds/8691_1_125_02_0.pdf
BioactivityPrednisolone disodium phosphate is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.Target: Glucocorticoid ReceptorPrednisolone irreversibly binds with glucocorticoid receptors (GR) alpha and beta for which they have a high affinity. Prednisolone can activate and influence biochemical behaviour of most cells. The steroid/receptor complexes dimerise and interact with cellular DNA in the nucleus, binding to steroid-response elements and modifying gene transcription. They induce synthesis of some proteins, and inhibit synthesis of others. Prednisolone exerted a delayed biphasic effect on the resistant CCRF-CEM leukemic cell line, necrotic at low doses and apoptotic at higher doses. At low doses, prednisolone exerted a pre-dominant mitogenic effect despite its induction on total cell death, while at higher doses, prednisolone's mitogenic and cell death effects were counterbalanced [1, 2]. Related Catalog Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor Research Areas >> Inflammation/Immunology References [1]. Lambrou, G.I., et al., Prednisolone exerts late mitogenic and biphasic effects on resistant acute lymphoblastic leukemia cells: Relation to early gene expression. Leuk Res, 2009. 33(12): p. 1684-95. [2]. http://en.wikipedia.org/wiki/Prednisolone Chemical & Physical Properties Boiling Point 100 °C Molecular Formula C21H27Na2O8P Molecular Weight 484.388 Flash Point 361.9ºC Exact Mass 484.123901 PSA 156.83000 LogP 2.55100 Vapour Pressure 4.17E-21mmHg at 25°C InChIKey VJZLQIPZNBPASX-OJJGEMKLSA-L SMILES CC12C=CC(=O)C=C1CCC1C2C(O)CC2(C)C1CCC2(O)C(=O)COP(=O)([O-])[O-].[Na+].[Na+]
Use ofPrednisolone disodium phosphate is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.Target: Glucocorticoid ReceptorPrednisolone irreversibly binds with glucocorticoid receptors (GR) alpha and beta for which they have a high affinity. Prednisolone can activate and influence biochemical behaviour of most cells. The steroid/receptor complexes dimerise and interact with cellular DNA in the nucleus, binding to steroid-response elements and modifying gene transcription. They induce synthesis of some proteins, and inhibit synthesis of others. Prednisolone exerted a delayed biphasic effect on the resistant CCRF-CEM leukemic cell line, necrotic at low doses and apoptotic at higher doses. At low doses, prednisolone exerted a pre-dominant mitogenic effect despite its induction on total cell death, while at higher doses, prednisolone's mitogenic and cell death effects were counterbalanced [1, 2]. Properties Name Prednisolone phosphate sodium Synonym More Synonyms Prednisolone Sodium Phosphate Biological Activity Description Prednisolone disodium phosphate is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.Target: Glucocorticoid ReceptorPrednisolone irreversibly binds with glucocorticoid receptors (GR) alpha and beta for which they have a high affinity. Prednisolone can activate and influence biochemical behaviour of most cells. The steroid/receptor complexes dimerise and interact with cellular DNA in the nucleus, binding to steroid-response elements and modifying gene transcription. They induce synthesis of some proteins, and inhibit synthesis of others. Prednisolone exerted a delayed biphasic effect on the resistant CCRF-CEM leukemic cell line, necrotic at low doses and apoptotic at higher doses. At low doses, prednisolone exerted a pre-dominant mitogenic effect despite its induction on total cell death, while at higher doses, prednisolone's mitogenic and cell death effects were counterbalanced [1, 2]. Related Catalog Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor Research Areas >> Inflammation/Immunology References [1]. Lambrou, G.I., et al., Prednisolone exerts late mitogenic and biphasic effects on resistant acute lymphoblastic leukemia cells: Relation to early gene expression. Leuk Res, 2009. 33(12): p. 1684-95. [2]. http://en.wikipedia.org/wiki/Prednisolone Chemical & Physical Properties Molecular Formula C21H27Na2O8P Exact Mass 484.123901 PSA 156.83000 LogP 2.55100 InChIKey VJZLQIPZNBPASX-OJJGEMKLSA-L
Transport InfoProduct name: Purity: 0.0%
MSDS Transport InfoModule 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified
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