CAS Number132539-06-1
SynonymsOlanzapine; 2-Methyl-4-(4-methyl-1-piperazinyl)- 10H-thieno[2,3-b][1,5]benzodiazepine; 2-Methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine; 2-Methyl-4-(4-methylpiperazin-1-yl)-10H-benzo[b]thieno[2,3-e][1,4]diazepine; 2-méthyl-4-(4-méthylpipérazin-1-yl)-10H-thiéno[2,3-b][1,5]benzodiazépine; 2-Methyl-4-(4-methyl-1-piperazinyl)- 10H-thieno[2,3-b][1,5]benzodiazepine LY-170053; Integrol; Oltal; Larmac; ZYPREXA; OLANZAPINE FORM I; 2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine; 2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno2,3-b1,5benzodiazepine; lanzac; Oleanz; 2-Methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepin; Oliza; MFCD00866702; EINECS 200-835-2
Molecular FormulaC17H20N4S
Molecular Weight312.43
Purity98/ USP32%
Density1.3±0.1 g/cm3
Boiling Point476.0±55.0 °C at 760 mmHg
Melting Point195°C
AppearanceLight yellow crystalline powder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 132539-06-1 |
| Catalog No. | 2A-9008631 |
| Chinese Name | 奥氮平 |
| Synonyms | Olanzapine; 2-Methyl-4-(4-methyl-1-piperazinyl)- 10H-thieno[2,3-b][1,5]benzodiazepine; 2-Methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine; 2-Methyl-4-(4-methylpiperazin-1-yl)-10H-benzo[b]thieno[2,3-e][1,4]diazepine; 2-méthyl-4-(4-méthylpipérazin-1-yl)-10H-thiéno[2,3-b][1,5]benzodiazépine; 2-Methyl-4-(4-methyl-1-piperazinyl)- 10H-thieno[2,3-b][1,5]benzodiazepine LY-170053; Integrol; Oltal; Larmac; ZYPREXA; OLANZAPINE FORM I; 2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine; 2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno2,3-b1,5benzodiazepine; lanzac; Oleanz; 2-Methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepin; Oliza; MFCD00866702; EINECS 200-835-2 |
| Molecular Formula | C17H20N4S |
| Molecular Weight | 312.43 |
| Purity | 98/ USP32 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 476.0±55.0 °C at 760 mmHg |
| Melting Point | 195°C |
| Appearance | Light yellow crystalline powder |
| Storage Condition | -20°C Freezer |
| Application | Olanzapine (LY170053) is a high-affinity antagonist of 5-HT2 and D2 receptors. |
| HTC | 2934999090 |
| MDL Number | MFCD00866702 |
| SMILES | CN1CCN(CC1)C2=Nc3ccccc3Nc4sc(C)cc24 |
| InChI | 1S/C17H20N4S/c1-12-11-13-16(21-9-7-20(2)8-10-21)18-14-5-3-4-6-15(14)19-17(13)22-12/h3-6,11,19H,7-10H2,1-2H3 |
| InChI Key | KVWDHTXUZHCGIO-UHFFFAOYSA-N |
| Beilstein/REAXYS | 7655141 |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/8631_1_132539_06_1.pdf |
| Bioactivity | Olanzapine(LY170053) is a high affinity for 5-HT2 serotonin and D2 dopamine receptor antagonist.IC50 Value:Target: 5-HT ReceptorOlanzapine is a thienobenzodiazepine that blocks especially the serontonin (5-hydroxytryptamine [5-HT]) 5-HT2A and the dopamine D2 receptors (Ki values are 4 and 11 nM respectively) as well as muscarinic (M1), histamine (H1), 5-HT2C, 5-HT3 to 5-HT6, adrenergic (α(l)), and D4 receptors. Atypical antipsychotic for the treatment of schizophrenia. Olanzapine displays anticholinergic properties. Related Catalog Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Autophagy >> Mitophagy Research Areas >> Neurological Disease References [1]. Cipriani A, Rendell JM, Geddes J. Olanzapine in long-term treatment for bipolar disorder. Cochrane Database Syst Rev. 2009 Jan 21;(1):CD004367. doi: 10.1002/14651858. [2]. Meera Narasimhan, Travis O Bruce, and Prakash Masand. Review of olanzapine in the management of bipolar disorders. Neuropsychiatr Dis Treat. 2007 October; 3(5): 579-587. [3]. Vieta E. Olanzapine in bipolar disorder. Expert Opin Pharmacother. 2004 Jul;5(7):1613-9. [4]. Bymaster FP, Calligaro DO, Falcone JF et al. Radioreceptor binding profile of the atypical antipsychotic olanzapine. Neuropsychopharmacology. 1996 Feb;14(2):87-96. [5]. Moore NA, Tye NC, Axton MS, Risius FC. The behavioral pharmacology of olanzapine, a novel "atypical" antipsychotic agent. J Pharmacol Exp Ther. 1992 Aug;262(2):545-51. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 476.0±55.0 °C at 760 mmHg Melting Point 195°C Molecular Formula C17H20N4S Molecular Weight 312.432 Flash Point 241.7±31.5 °C Exact Mass 312.140869 PSA 59.11000 LogP 2.18 Vapour Pressure 0.0±1.2 mmHg at 25°C Index of Refraction 1.709 InChIKey KVWDHTXUZHCGIO-UHFFFAOYSA-N SMILES Cc1cc2c(s1)Nc1ccccc1N=C2N1CCN(C)CC1 Storage condition -20°C Freezer |
| Use of | Properties Articles112 Name olanzapine Synonym More Synonyms Olanzapine Biological Activity Related Catalog Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Autophagy >> Mitophagy Research Areas >> Neurological Disease References [2]. Meera Narasimhan, Travis O Bruce, and Prakash Masand. Review of olanzapine in the management of bipolar disorders. Neuropsychiatr Dis Treat. 2007 October; 3(5): 579-587. [3]. Vieta E. Olanzapine in bipolar disorder. Expert Opin Pharmacother. 2004 Jul;5(7):1613-9. [4]. Bymaster FP, Calligaro DO, Falcone JF et al. Radioreceptor binding profile of the atypical antipsychotic olanzapine. Neuropsychopharmacology. 1996 Feb;14(2):87-96. [5]. Moore NA, Tye NC, Axton MS, Risius FC. The behavioral pharmacology of olanzapine, a novel "atypical" antipsychotic agent. J Pharmacol Exp Ther. 1992 Aug;262(2):545-51. Chemical & Physical Properties Molecular Formula C17H20N4S Exact Mass 312.140869 PSA 59.11000 Index of Refraction 1.709 InChIKey KVWDHTXUZHCGIO-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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