CAS Number155141-29-0
Synonyms(5-(4-(2-(N-Methyl-N-(2-pyridinyl)amino)ethoxy)benzylidene)-2,4-thiazolidinedione; (5E)-5-(4-{2-[Methyl(pyridin-2-yl)amino]ethoxy}benzylidene)-1,3-thiazolidine-2,4-dione; 5-[[4-[2-(Methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione maleate salt; MFCD03427306; (5E)-5-(4-{2-[Methyl(2-pyridinyl)amino]ethoxy}benzylidene)-1,3-thiazolidine-2,4-dione; Rosiglitazone maleate; Rosiglitazone (maleate)
Molecular FormulaC22H23N3O7S
Molecular Weight473.50
Purity98%
Density1.4±0.1 g/cm3
Boiling Point585ºC at 760 mmHg
Melting Point235-240°C
Appearanceoff-white solid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 155141-29-0 |
| Catalog No. | 2A-9008729 |
| Chinese Name | 马来酸罗格列酮 |
| Synonyms | (5-(4-(2-(N-Methyl-N-(2-pyridinyl)amino)ethoxy)benzylidene)-2,4-thiazolidinedione; (5E)-5-(4-{2-[Methyl(pyridin-2-yl)amino]ethoxy}benzylidene)-1,3-thiazolidine-2,4-dione; 5-[[4-[2-(Methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione maleate salt; MFCD03427306; (5E)-5-(4-{2-[Methyl(2-pyridinyl)amino]ethoxy}benzylidene)-1,3-thiazolidine-2,4-dione; Rosiglitazone maleate; Rosiglitazone (maleate) |
| Molecular Formula | C22H23N3O7S |
| Molecular Weight | 473.50 |
| Purity | 98 |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 585ºC at 760 mmHg |
| Melting Point | 235-240°C |
| Appearance | off-white solid |
| Storage Condition | Sealed in a cool, dry environment |
| Application | Rosiglitazone maleate is a potent and selective activator of PPARγ. The EC50 values for PPARγ1, PPARγ2 and PPARγ are 30 nM, 100 nM and 60 nM respectively, and the Kd value for PPARγ is approximately |
| HTC | 2933990090 |
| MDL Number | MFCD03427306 |
| SMILES | S1C(C(=O)[N+H2]C1=O)Cc2ccc(cc2)OCC[N+H](C)c3ncccc3.[O-]C(=O)\C=C/C(=O)[O-] |
| InChI | 1S/C18H19N3O3S.C4H4O4/c1-21(16-4-2-3-9-19-16)10-11-24-14-7-5-13(6-8-14)12-15-17(22)20-18(23)25-15;5-3(6)1-2-4(7)8/h2-9,15H,10-12H2,1H3,(H,20,22,23);1-2H,(H,5,6)(H,7,8)/b;2-1- |
| InChI Key | SUFUKZSWUHZXAV-BTJKTKAUSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/8729_1_155141_29_0.pdf |
| Use of | Rosiglitazone maleate is a potent and selective activator of PPARγ, with EC50s of 30 nM, 100 nM and 60 nM for PPARγ1, PPARγ2, and PPARγ, respectively, and a Kd of appr 40 nM for PPARγ; Rosiglitazone maleate is also an modulator of TRP channels, inhibits TRP melastatin 2 (TRPM2), TRPM3 and activates TRP canonical 5 (TRPC5). Properties Name rosiglitazone maleate Synonym More Synonyms Rosiglitazone maleate Biological Activity Description Rosiglitazone maleate is a potent and selective activator of PPARγ, with EC50s of 30 nM, 100 nM and 60 nM for PPARγ1, PPARγ2, and PPARγ, respectively, and a Kd of appr 40 nM for PPARγ; Rosiglitazone maleate is also an modulator of TRP channels, inhibits TRP melastatin 2 (TRPM2), TRPM3 and activates TRP canonical 5 (TRPC5). Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease PPARγ1:30 nM (EC50) PPARγ2:100 nM (EC50) References [1]. Lehmann JM, et al. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma). J Biol Chem. 1995 Jun 2;270(22):12953-6. [3]. Thouennon E, et al. Rosiglitazone-activated PPARγ induces neurotrophic factor-α1 transcription contributing to neuroprotection. J Neurochem. 2015 Aug;134(3):463-70. [5]. Ateyya H, et al. Beneficial effects of rosiglitazone and losartan combination in diabetic rats. Can J Physiol Pharmacol. 2018 Mar;96(3):215-220. Chemical & Physical Properties Molecular Formula C22H23N3O7S PSA 96.83000 Index of Refraction 1.688 InChIKey SUFUKZSWUHZXAV-BTJKTKAUSA-N Safety Information Hazard Codes Xi HS Code 2933990090 Synthetic Route Total: 1 Page Maleic acid CAS#:110-16-7 Rosiglitazone CAS#:122320-73-4 Rosiglitazone m... CAS#:155141-29-0 Precursor & DownStream Precursor 2 CAS#:110-16-7 Maleic acid CAS#:122320-73-4 Rosiglitazone DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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