CAS Number91374-20-8
Synonyms2H-Indol-2-one, 4-[2-(dipropylamino)ethyl]-1,3-dihydro-, hydrochloride (1:1); 4-[2-(Dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one hydrochloride; 4-[2-(Dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one hydrochloride (1:1); 4-[2-(Dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-onhydrochlorid; UNII-D7ZD41RZI9; ropinirole hcl; 4-[2-(dipropylamino)éthyl]-1,3-dihydro-2H-indol-2-one chlorhydrate; Adartrel; MFCD01754173; Ropinirole hydrochloride; 2H-indol-2-one, 4-[2-(dipropylamino)ethyl]-1,3-dihydro-, monohydrochloride; Requip; Ropinirole (hydrochloride)
Molecular FormulaC16H25ClN2O
Molecular Weight296.84
Purity98%
Boiling Point410.5ºC at 760mmHg
Melting Point241-243ºC
Appearanceoff-white solid
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 91374-20-8 |
| Catalog No. | 2A-9008728 |
| Chinese Name | 盐酸罗匹尼罗 |
| Synonyms | 2H-Indol-2-one, 4-[2-(dipropylamino)ethyl]-1,3-dihydro-, hydrochloride (1:1); 4-[2-(Dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one hydrochloride; 4-[2-(Dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one hydrochloride (1:1); 4-[2-(Dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-onhydrochlorid; UNII-D7ZD41RZI9; ropinirole hcl; 4-[2-(dipropylamino)éthyl]-1,3-dihydro-2H-indol-2-one chlorhydrate; Adartrel; MFCD01754173; Ropinirole hydrochloride; 2H-indol-2-one, 4-[2-(dipropylamino)ethyl]-1,3-dihydro-, monohydrochloride; Requip; Ropinirole (hydrochloride) |
| Molecular Formula | C16H25ClN2O |
| Molecular Weight | 296.84 |
| Purity | 98 |
| Boiling Point | 410.5ºC at 760mmHg |
| Melting Point | 241-243ºC |
| Appearance | off-white solid |
| Storage Condition | Room temp |
| Application | Ropinirole (SKF101468) hydrochloride is a dopamine receptor D2 inhibitor with an IC50 of 29 nM. |
| HTC | 2933790090 |
| UN(IATA) | UN3077 |
| PubChem ID | 329823523 |
| MDL Number | MFCD01754173 |
| SMILES | Cl.CCCN(CCC)CCc1cccc2NC(=O)Cc12 |
| InChI | 1S/C16H24N2O.ClH/c1-3-9-18(10-4-2)11-8-13-6-5-7-15-14(13)12-16(19)17-15;/h5-7H,3-4,8-12H2,1-2H3,(H,17,19);1H |
| InChI Key | XDXHAEQXIBQUEZ-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | 9.0 |
| Risk Codes | R22-50/53 |
| Safety Description | S36-60-61 |
| MSDS | msds/8728_1_91374_20_8.pdf |
| Use of | Properties Articles27 Name 4-(2-(Dipropylamino)ethyl)indolin-2-one hydrochloride Synonym More Synonyms Ropinirole hydrochloride Biological Activity Related Catalog Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease References [1]. Eden, R.J., et al., Preclinical pharmacology of ropinirole (SK&F 101468-A) a novel dopamine D2 agonist. Pharmacol Biochem Behav, 1991. 38(1): p. 147-54. [2]. Iida, M., et al., Dopamine D2 receptor-mediated antioxidant and neuroprotective effects of ropinirole, a dopamine agonist. Brain Res, 1999. 838(1-2): p. 51-9. [3]. Lam, Y.W., Clinical pharmacology of dopamine agonists. Pharmacotherapy, 2000. 20(1 Pt 2): p. 17S-25S. [4]. Allen, R., et al., Ropinirole decreases periodic leg movements and improves sleep parameters in patients with restless legs syndrome. Sleep, 2004. 27(5): p. 907-14. Chemical & Physical Properties Exact Mass 296.165527 PSA 32.34000 LogP 3.78570 InChIKey XDXHAEQXIBQUEZ-UHFFFAOYSA-N Storage condition Room temp Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : 2H-Indol-2-one, 1,3-dihydro-4-(2-(dipropylamino)ethyl)-, monohydrochloride CAS REGISTRY NUMBER : 91374-20-8 LAST UPDATED : DATA ITEMS CITED : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : REFERENCE : YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 24(Suppl 11),S1725,199 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : REFERENCE : YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 24(Suppl 11),S1725,199 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Liver - changes in liver weight Endocrine - changes in adrenal weight Related to Chronic Data - changes in ovarian weight REFERENCE : YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 24(Suppl 11),S1731,199 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Kidney, Ureter, Bladder - other changes Endocrine - changes in adrenal weight REFERENCE : YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 24(Suppl 11),S1731,199 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Primate - monkey DOSE/DURATION : TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - ptosis Behavioral - excitement Skin and Appendages - hair REFERENCE : YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 24(Suppl 11),S1741,199 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Primate - monkey DOSE/DURATION : TOXIC EFFECTS : Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Related to Chronic Data - changes in ovarian weight Related to Chronic Data - changes in testicular weight REFERENCE : YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 24(Suppl 11),S1741,199 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SEX/DURATION : female 2 week(s) pre-mating - 20 day(s) post-birth TOXIC EFFECTS : Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) REFERENCE : YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 24(Suppl 11),S1747,199 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SEX/DURATION : female 6-15 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) REFERENCE : YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 24(Suppl 11),S1747,199 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SEX/DURATION : female 15-21 day(s) after conception lactating female 21 day(s) post-birth TOXIC EFFECTS : Reproductive - Effects on Newborn - behavioral REFERENCE : YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 24(Suppl 11),S1747,199 Safety Information GHS07, GHS09 Signal Word Warning Hazard Statements H302-H400 Precautionary Statements P301 + P312 + P330 Personal Protective Equipment dust mask type N95 (US);Eyeshields;Faceshields;Gloves Hazard Codes Xn,N Risk Phrases R22 RTECS NM3288250 Hazard Class 9.0 HS Code 2933790090 Synthetic Route 2-(2-(2-(Diprop... CAS#:91374-25-3 Ropinirole hydr... CAS#:91374-20-8 Dipropylamine CAS#:142-84-7 4-(2'-BROMOETHY... CAS#:120427-96-5 Ropinirole hydr... CAS#:91374-20-8 Dipropylamine CAS#:142-84-7 4-(2'-BROMOETHY... CAS#:120427-95-4 Ropinirole hydr... CAS#:91374-20-8 Precursor & DownStream Precursor 10 CAS#:91374-25-3 2-(2-(2-(Diprop... CAS#:142-84-7 Dipropylamine CAS#:120427-96-5 4-(2'-BROMOETHY... CAS#:120427-95-4 4-(2'-BROMOETHY... DownStream 1 CAS#:91374-21-9 Ropinirole |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 9.0% Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0% |
| Related Products in API & Advanced Intermediates | ||
|---|---|---|
| Oxandrolone | 53-39-4 | 2A-9008636 |
| Phenoxymethylpenicillinic acid potassium | 132-98-9 | 2A-9008659 |
| Phenyl-D5-7-hydroxywarfarin | 94820-65-2 | 2A-9008670 |
| Prednisolone sodium phosphate | 125-02-0 | 2A-9008691 |
| Prednisolone succinate | 2920-86-7 | 2A-9008692 |
| Rosiglitazone maleate | 155141-29-0 | 2A-9008729 |
| Terazosin hydrochloride dihydrate | 70024-40-7 | 2A-9008777 |
| Testosterone | 58-22-0 | 2A-9008796 |
| Testosterone cypionate | 58-20-8 | 2A-9008797 |
| Testosterone decanoate | 5721-91-5 | 2A-9008798 |
| Browse all API & Advanced Intermediates products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS