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Formononetin structure, CAS 485-72-3

Formononetin

CAS Number485-72-3

Synonyms7-Hydroxy-3-(4-methoxyphenyl)-4H-chromen-4-one; Formononetol; 4'-O-methyl-daidzein; BIOCHANIN B; ForMonentin; BIOCHANIN A; Flavosil; 7-Hydroxy-4'-methoxyisoflavone; Neochanin; Myconate; MFCD00016948; BiocaninB; FORMONETIN; 7-Hydroxy-3-(4-methoxyphenyl)-4H-1-benzopyran-4-one; EINECS 207-623-9; Formononetin; 7-Hydroxy-3-(4-methoxyphenyl)chromone; forMonoetin

Molecular FormulaC16H12O4

Molecular Weight268.26

Purity≥99.0 (TLC)%

Density1.3±0.1 g/cm3

Boiling Point479.4±45.0 °C at 760 mmHg

Melting Point257-261 °C

Flash Point

Appearancesolid

EINECS207-623-9

MSDSChineseEnglish

SymbolTransport

Signal WordWarning

Cat. No.: 2A-9007878 Purity: ≥99.0 (TLC)%
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Quality Control of [ 485-72-3 ] Purity: ≥99.0 (TLC)% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number485-72-3
Catalog No.2A-9007878
Chinese Name芒柄花黄素
Synonyms7-Hydroxy-3-(4-methoxyphenyl)-4H-chromen-4-one; Formononetol; 4'-O-methyl-daidzein; BIOCHANIN B; ForMonentin; BIOCHANIN A; Flavosil; 7-Hydroxy-4'-methoxyisoflavone; Neochanin; Myconate; MFCD00016948; BiocaninB; FORMONETIN; 7-Hydroxy-3-(4-methoxyphenyl)-4H-1-benzopyran-4-one; EINECS 207-623-9; Formononetin; 7-Hydroxy-3-(4-methoxyphenyl)chromone; forMonoetin
Molecular FormulaC16H12O4
Molecular Weight268.26
Purity≥99.0 (TLC)
Density1.3±0.1 g/cm3
Boiling Point479.4±45.0 °C at 760 mmHg
Melting Point257-261 °C
Appearancesolid
Storage ConditionStore in a sealed container in a ventilated and dr
ApplicationFormononetin (Formononetol; Flavosil) is extracted from red clover and can inhibit the proliferation of DU-145/PC-3 cells in a dose-dependent manner.
EINECS207-623-9
HTC2932999099
PubChem ID57651100
MDL NumberMFCD00016948
SMILESCOc1ccc(cc1)C2=COc3cc(O)ccc3C2=O
InChI1S/C16H12O4/c1-19-12-5-2-10(3-6-12)14-9-20-15-8-11(17)4-7-13(15)16(14)18/h2-9,17H,1H3
InChI KeyHKQYGTCOTHHOMP-UHFFFAOYSA-N
Beilstein/REAXYS237979
NACRES CodeNA.47
UNSPSC12352200
Hazard SymbolsTransport
MSDSmsds/7878_1_485_72_3.pdf
BioactivityFormononetin (Formononetol; Flavosil) is a bioactive component extracted from the red clover; inhibits the proliferation of DU-145/PC-3 cells in a dose-dependent manner.IC50 value:Target: anti-cancer in vitro: formononetin inhibited the proliferation of DU-145 cells in a dose-dependent manner. DU-145 cells treated with different concentrations of formononetin displayed obvious morphological changes of apoptosis under fluorescence microscopy. In addition, formononetin increased the proportion of early apoptotic DU-145 cells, down-regulated the protein levels of Bcl-2 and up-regulated those of RASD1 and Bax [1]. Formononetin significantly inhibited the cell growth of PC-3 in a dose-dependent manner, but no such effect was observed in RWPE1 cells. Formononetin treatment contributed to the reduced Bcl-2 protein level and the elevated Bax expression in PC-3 cells, thereby resulting in the increasing Bax/Bcl-2 ratios. Furthermore, the phosphorylated level of p38 in PC-3 cells was activated through the FN treatment, whereas the endogenous Akt phosphorylation was blocked [2]. Compared with the control, formononetin inhibited the proliferation of MCF-7 cells and effectively induced cell cycle arrest. The levels of p-IGF-1?R, p-Akt, cyclin D1 protein expression, and cyclin D1 mRNA expression were also downregulated [3].in vivo: formononetin also prevented the tumor growth of human breast cancer cells in nude mouse xenografts [3]. Related Catalog Natural Products >> Flavonoids Research Areas >> Cancer References [1]. Liu XJ, et al. Up-regulating of RASD1 and apoptosis of DU-145 human prostate cancer cells induced by formononetin in vitro. Asian Pac J Cancer Prev. 2014;15(6):2835-9. [2]. Zhang X, et al. Formononetin induces apoptosis in PC-3 prostate cancer cells through enhancing the Bax/Bcl-2 ratios and regulating the p38/Akt pathway. Nutr Cancer. 2014;66(4):656-61. [3]. Chen J, et al. Formononetin induces cell cycle arrest of human breast cancer cells via IGF1/PI3K/Akt pathways in vitro and in vivo. Horm Metab Res. 2011 Sep;43(10):681-6. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 479.4±45.0 °C at 760 mmHg Melting Point 256-260 °C Molecular Formula C16H12O4 Molecular Weight 268.264 Flash Point 183.4±22.2 °C Exact Mass 268.073547 PSA 59.67000 LogP 2.96 Vapour Pressure 0.0±1.2 mmHg at 25°C Index of Refraction 1.641 InChIKey HKQYGTCOTHHOMP-UHFFFAOYSA-N SMILES COc1ccc(-c2coc3cc(O)ccc3c2=O)cc1 Storage condition Refrigerator
Use ofProperties Articles56 Name formononetin Synonym More Synonyms Formononetin Biological Activity Related Catalog Natural Products >> Flavonoids Research Areas >> Cancer References [1]. Liu XJ, et al. Up-regulating of RASD1 and apoptosis of DU-145 human prostate cancer cells induced by formononetin in vitro. Asian Pac J Cancer Prev. 2014;15(6):2835-9. Chemical & Physical Properties Molecular Formula C16H12O4 Exact Mass 268.073547 PSA 59.67000 Index of Refraction 1.641 InChIKey HKQYGTCOTHHOMP-UHFFFAOYSA-N Storage condition Refrigerator
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport InfoShipping Name: UN
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available
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