CAS Number20958-18-3
Synonyms1,6-Dimethyl-1,2-dihydrophenanthro[1,2-b]furan-10,11-dione; Dihydrotanshinone; Dihydroisotanshinone I; Phenanthro[3,2-b]furan-7,11-dione,8,9-dihydro-4,8-dimethyl; 15,16-dihydroisotanshinone I
Molecular FormulaC18H14O3
Molecular Weight278.30
Purity≥98 (HPLC)%
Density1.3±0.1 g/cm3
Boiling Point479.2±45.0 °C at 760 mmHg
Appearancepowder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 20958-18-3 |
| Catalog No. | 2A-9007595 |
| Chinese Name | 二氢丹参酮 |
| Synonyms | 1,6-Dimethyl-1,2-dihydrophenanthro[1,2-b]furan-10,11-dione; Dihydrotanshinone; Dihydroisotanshinone I; Phenanthro[3,2-b]furan-7,11-dione,8,9-dihydro-4,8-dimethyl; 15,16-dihydroisotanshinone I |
| Molecular Formula | C18H14O3 |
| Molecular Weight | 278.30 |
| Purity | ≥98 (HPLC) |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 479.2±45.0 °C at 760 mmHg |
| Appearance | powder |
| Application | Dihydroisotanshinone I is an active substance derived from the widely used traditional Chinese medicine Salvia miltiorrhiza. |
| HTC | 2932999099 |
| PubChem ID | 329798655 |
| MDL Number | MFCD28016070 |
| SMILES | C[C@H]1COC(C2=C3C4=C(C=C2)C(C)=CC=C4)=C1C(C3=O)=O |
| InChI | 1S/C18H14O3/c1-9-4-3-5-12-11(9)6-7-13-15(12)17(20)16(19)14-10(2)8-21-18(13)14/h3-7,10H,8H2,1-2H3/t10-/m0/s1 |
| InChI Key | HARGZZNYNSYSGJ-JTQLQIEISA-N |
| NACRES Code | NA.25 |
| UNSPSC | 12352200 |
| MSDS | msds/7595_1_20958_18_3.pdf |
| Use of | Dihydroisotanshinone I is a bioactive compound present in a widely used traditional Chinese medicine named danshen. Properties Name 4,8-dimethyl-8,9-dihydronaphtho[2,1-f][1]benzofuran-7,11-dione Synonym More Synonyms Dihydroisotanshinone I Biological Activity Description Dihydroisotanshinone I is a bioactive compound present in a widely used traditional Chinese medicine named danshen. Related Catalog Research Areas >> Cancer Natural Products >> Quinones In Vitro Dihydroisotanshinone I can inhibit the migration of both androgen-dependent and androgen-independent prostate cancer cells. Dihydroisotanshinone diminishes the ability of prostate cancer cells to recruit macrophages and reduces the secretion of chemokine (C-C motif) ligand 2 (CCL2) from both macrophages and prostate cancer cells in a dose-dependent manner. It inhibits the protein expression of p-STAT3 and decreases the translocation of STAT3 into nuclear chromatin. It also suppresses the expression of tumor epithelial-mesenchymal transition genes, including RhoA and SNAI1[1]. Pretreating the cells with dihydroisotanshinone I at concentrations ranging from 2.5 μM to 20 μM for 24 hours cause dose-dependent protection against hepatotoxicity induced by menadione. Adding dihydroisotanshinone I to freshly isolated hepatocytes at concentrations between 50 nM to 200 nM inhibit NADH-induced superoxide production dose-dependently[2]. Cell Assay Dihydroisotanshinone I is dissolved in ethyl acetate and mixed with the culture medium. The final concentration of ethyl acetate is 0.1% (v/v). Cell are treated with 2.5, 5, 10, and 20 μM dihydroisotanshinone I for 24 hours. The cell viability is measured using the MTT assay[2]. References [2]. Ip SP, et al. Dihydroisotanshinone I protects against menadione-induced toxicity in a primary culture of rat hepatocytes. Planta Med. 2002 Dec;68(12):1077-81. Chemical & Physical Properties Molecular Formula C18H14O3 Exact Mass 278.094299 PSA 43.37000 Index of Refraction 1.671 InChIKey KXNYCALHDXGJSF-UHFFFAOYSA-N Safety Information HS Code 2932999099 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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