CAS Number76824-35-6
Synonymspepdul; Pepcid; Pepcidine; fibonel; peptan; muclox; ganor; Famotidine; MFCD00079297; Ifada; N'-(Aminosulfonyl)-3-([2-(diaminomethyleneamino)-4-thiazolyl]methylthio)propanamidine; motiax; Gaster
Molecular FormulaC8H15N7O2S3
Molecular Weight337.45
Purity98.5%
Density1.8±0.1 g/cm3
Boiling Point662.4±65.0 °C at 760 mmHg
Melting Point325.4-327.2 °F (163-164°C)
AppearanceWhite to off-white crystalline powder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 76824-35-6 |
| Catalog No. | 2A-9007799 |
| Chinese Name | 法莫替丁 |
| Synonyms | pepdul; Pepcid; Pepcidine; fibonel; peptan; muclox; ganor; Famotidine; MFCD00079297; Ifada; N'-(Aminosulfonyl)-3-([2-(diaminomethyleneamino)-4-thiazolyl]methylthio)propanamidine; motiax; Gaster |
| Molecular Formula | C8H15N7O2S3 |
| Molecular Weight | 337.45 |
| Purity | 98.5 |
| Density | 1.8±0.1 g/cm3 |
| Boiling Point | 662.4±65.0 °C at 760 mmHg |
| Melting Point | 325.4-327.2 °F (163-164°C) |
| Appearance | White to off-white crystalline powder |
| Water Solubility | 1.1 mg/mL |
| Storage Condition | Store in a sealed container in a cool, dry place. |
| Application | Famotidine is a histamine H2 receptor antagonist that inhibits gastric juice secretion. |
| HTC | 2935009090 |
| PubChem ID | 329823085 |
| MDL Number | MFCD00079297 |
| SMILES | N\C(N)=N\c1nc(CSCCC(=N)NS(N)(=O)=O)cs1 |
| InChI | 1S/C8H15N7O2S3/c9-6(15-20(12,16)17)1-2-18-3-5-4-19-8(13-5)14-7(10)11/h4H,1-3H2,(H2,9,15)(H2,12,16,17)(H4,10,11,13,14) |
| InChI Key | XUFQPHANEAPEMJ-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | Transport |
| MSDS | msds/7799_1_76824_35_6.pdf |
| Bioactivity | Famotidine is a competitive histamine H2-receptor antagonist. Its main pharmacodynamic effect is the inhibition of gastric secretion.Target: Histamine H2 ReceptorFamotidine is a histamine H2-receptor antagonist that inhibits stomach acid production, and it is commonly used in the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD/GORD). Famotidine Group(2 mg/kg/day) were significantly lower than the equivalent parameters for the Control Group on both the third and seventh days post-surgery. famotidine exerts detrimental effects on the anastomotic bursting pressure and hydroxyproline content of perianastomotic tissues in the colon of rats [1]. famotidine increased the transgastric potential difference (PD) and promoted the recovery of decreased transgastric PD induced by acidified ethanol in rats. The preventive effect of famotidine on gastric lesions is attributable not only to suppression of acid secretion but to activation of the gastric mucosal defensive mechanisms [2]. Related Catalog Signaling Pathways >> GPCR/G Protein >> Histamine Receptor Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Metabolic Disease References [1]. Inan, A., et al., Effects of the histamine H2 receptor antagonist famotidine on the healing of colonic anastomosis in rats. Clinics (Sao Paulo), 2009. 64(6): p. 567-70. [2]. Miyata, K., et al., Studies on the mechanism for the gastric mucosal protection by famotidine in rats. Jpn J Pharmacol, 1991. 55(2): p. 211-22. Chemical & Physical Properties Density 1.8±0.1 g/cm3 Boiling Point 662.4±65.0 °C at 760 mmHg Melting Point 163-164°C Molecular Formula C8H15N7O2S3 Molecular Weight 337.445 Flash Point 354.4±34.3 °C Exact Mass 337.044922 PSA 235.25000 LogP -0.40 Vapour Pressure 0.0±2.0 mmHg at 25°C Index of Refraction 1.808 InChIKey XUFQPHANEAPEMJ-UHFFFAOYSA-N SMILES NC(N)=Nc1nc(CSCCC(N)=NS(N)(=O)=O)cs1 Storage condition Hygroscopic, -20°C Freezer, Under Inert Atmosphere Water Solubility 1.1 mg/mL |
| Use of | Properties Articles88 Name famotidine Synonym More Synonyms Famotidine Biological Activity Related Catalog Signaling Pathways >> GPCR/G Protein >> Histamine Receptor Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Metabolic Disease References [1]. Inan, A., et al., Effects of the histamine H2 receptor antagonist famotidine on the healing of colonic anastomosis in rats. Clinics (Sao Paulo), 2009. 64(6): p. 567-70. [2]. Miyata, K., et al., Studies on the mechanism for the gastric mucosal protection by famotidine in rats. Jpn J Pharmacol, 1991. 55(2): p. 211-22. Chemical & Physical Properties Molecular Formula C8H15N7O2S3 Exact Mass 337.044922 PSA 235.25000 LogP -0.40 Index of Refraction 1.808 InChIKey XUFQPHANEAPEMJ-UHFFFAOYSA-N SMILES NC(N)=Nc1nc(CSCCC(N)=NS(N)(=O)=O)cs1 |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 35.0% |
| Transport Info | Product name: Purity: 99.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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