CAS Number80474-14-2
SynonymsFluticasone propionate (JAN/USAN); Flonase; FLUNASE; Flovent DPI; Flutide N; Flixonase; Flixotide; flutide; MFCD08064194; Fluticasone propionate; flovent diskus; Zoflut; Cutivate; FLOVENT; Fluticasone (propionate)
Molecular FormulaC25H31F3O5S
Molecular Weight500.57
Purity98%
Density1.3±0.1 g/cm3
Boiling Point568.3±50.0 °C at 760 mmHg
Melting Point275 °C
Appearancecrystalline solid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 80474-14-2 |
| Catalog No. | 2A-9007816 |
| Chinese Name | 氟替卡松丙酸酯 |
| Synonyms | Fluticasone propionate (JAN/USAN); Flonase; FLUNASE; Flovent DPI; Flutide N; Flixonase; Flixotide; flutide; MFCD08064194; Fluticasone propionate; flovent diskus; Zoflut; Cutivate; FLOVENT; Fluticasone (propionate) |
| Molecular Formula | C25H31F3O5S |
| Molecular Weight | 500.57 |
| Purity | 98 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 568.3±50.0 °C at 760 mmHg |
| Melting Point | 275 °C |
| Appearance | crystalline solid |
| Water Solubility | DMSO: ≥10 mg/mL |
| Storage Condition | Store at RT |
| Application | Fluticasone propionate is a glucocorticoid receptor (GR) agonist. |
| HTC | 2937229000 |
| PubChem ID | 329823565 |
| MDL Number | MFCD00866007 |
| SMILES | CCC(=O)O[C@@]1([C@H](C)C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C)C(=O)SCF |
| InChI | 1S/C25H31F3O5S/c1-5-20(31)33-25(21(32)34-12-26)13(2)8-15-16-10-18(27)17-9-14(29)6-7-22(17,3)24(16,28)19(30)11-23(15,25)4/h6-7,9,13,15-16,18-19,30H,5,8,10-12H2,1-4H3/t13-,15+,16+,18+,19+,22+,23+,24+,25+/m1/s1 |
| InChI Key | WMWTYOKRWGGJOA-CENSZEJFSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/7816_1_80474_14_2.pdf |
| Bioactivity | Fluticasone propionate is a high affinity, selective GR (glucocorticoid receptor) agonist which is derived from fluticasone used to treat asthma and allergic rhinitis.Target: Glucocorticoid ReceptorFluticasone propionate is a corticosteroid derived from fluticasone used to treat asthma and allergic rhinitis. It is also used to treat eosinophilic esophagitis. Fluticasone propionate is a synthetic trifluorinated glucocorticoid. It is highly lipophilic (logp octanol/water 3.69). In studies the topical drug has been associated with burning, stinging, skin irritation, blisters, dryness, skin infection, infected eczema, viral warts,impetigo, atopic dermatitis, pruritus, exacerbation of pruritus, exacerbation of eczema, erythema, and folliculitis.There are also numerous side effects associated with the oral version of this medication including headache, stuffy or runny nose, difficulty speaking, sore or irritated throat and painful white patches in the mouth or throat. Candidiasis of mouth and throat is reported as a "very common" side effect indicating that it occurs with a frequency greater than 1 in 10.Hoarseness is "common" indicating a frequency from 1 in 10 to 1 in 100. In both instances rinsing the mouth with water immediately after inhalation is recommended. Related Catalog Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor Research Areas >> Inflammation/Immunology References [1]. McKeage K. Fluticasone propionate/formoterol fumarate: a review of its use in persistent asthma. Drugs. 2013 Feb;73(2):195-206. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 568.3±50.0 °C at 760 mmHg Melting Point 275 °C Molecular Formula C25H31F3O5S Molecular Weight 500.571 Flash Point 297.5±30.1 °C Exact Mass 500.184418 PSA 105.97000 LogP 3.73 Vapour Pressure 0.0±3.5 mmHg at 25°C Index of Refraction 1.556 InChIKey WMWTYOKRWGGJOA-UHFFFAOYSA-N SMILES CCC(=O)OC1(C(=O)SCF)C(C)CC2C3CC(F)C4=CC(=O)C=CC4(C)C3(F)C(O)CC21C Storage condition Store at RT Water Solubility DMSO: ≥10 mg/mL |
| Use of | Fluticasone propionate is a high affinity, selective GR (glucocorticoid receptor) agonist which is derived from fluticasone used to treat asthma and allergic rhinitis.Target: Glucocorticoid ReceptorFluticasone propionate is a corticosteroid derived from fluticasone used to treat asthma and allergic rhinitis. It is also used to treat eosinophilic esophagitis. Fluticasone propionate is a synthetic trifluorinated glucocorticoid. It is highly lipophilic (logp octanol/water 3.69). In studies the topical drug has been associated with burning, stinging, skin irritation, blisters, dryness, skin infection, infected eczema, viral warts,impetigo, atopic dermatitis, pruritus, exacerbation of pruritus, exacerbation of eczema, erythema, and folliculitis.There are also numerous side effects associated with the oral version of this medication including headache, stuffy or runny nose, difficulty speaking, sore or irritated throat and painful white patches in the mouth or throat. Candidiasis of mouth and throat is reported as a "very common" side effect indicating that it occurs with a frequency greater than 1 in 10.Hoarseness is "common" indicating a frequency from 1 in 10 to 1 in 100. In both instances rinsing the mouth with water immediately after inhalation is recommended. Properties Articles48 Name fluticasone propionate Synonym More Synonyms Fluticasone propionate Biological Activity Description Fluticasone propionate is a high affinity, selective GR (glucocorticoid receptor) agonist which is derived from fluticasone used to treat asthma and allergic rhinitis.Target: Glucocorticoid ReceptorFluticasone propionate is a corticosteroid derived from fluticasone used to treat asthma and allergic rhinitis. It is also used to treat eosinophilic esophagitis. Fluticasone propionate is a synthetic trifluorinated glucocorticoid. It is highly lipophilic (logp octanol/water 3.69). In studies the topical drug has been associated with burning, stinging, skin irritation, blisters, dryness, skin infection, infected eczema, viral warts,impetigo, atopic dermatitis, pruritus, exacerbation of pruritus, exacerbation of eczema, erythema, and folliculitis.There are also numerous side effects associated with the oral version of this medication including headache, stuffy or runny nose, difficulty speaking, sore or irritated throat and painful white patches in the mouth or throat. Candidiasis of mouth and throat is reported as a "very common" side effect indicating that it occurs with a frequency greater than 1 in 10.Hoarseness is "common" indicating a frequency from 1 in 10 to 1 in 100. In both instances rinsing the mouth with water immediately after inhalation is recommended. Related Catalog Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor Research Areas >> Inflammation/Immunology References [1]. McKeage K. Fluticasone propionate/formoterol fumarate: a review of its use in persistent asthma. Drugs. 2013 Feb;73(2):195-206. Chemical & Physical Properties Molecular Formula C25H31F3O5S Exact Mass 500.184418 PSA 105.97000 Index of Refraction 1.556 InChIKey WMWTYOKRWGGJOA-UHFFFAOYSA-N Storage condition Store at RT |
| Transport Info | Product name: Purity: 0.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
| Related Products in API & Advanced Intermediates | ||
|---|---|---|
| Erythromycin-9-oxime | 13127-18-9 | 2A-9007681 |
| Estradiol cypionate | 313-06-4 | 2A-9007682 |
| Estradiol enanthate | 4956-37-0 | 2A-9007683 |
| Estrone 3-methyl ether | 1624-62-0 | 2A-9007685 |
| Famotidine | 76824-35-6 | 2A-9007799 |
| Hydrocortisone butyrate | 13609-67-1 | 2A-9008009 |
| Hydrocortisone sodium phosphate | 6000-74-4 | 2A-9008010 |
| Hydrocortisone succinate | 2203-97-6 | 2A-9008011 |
| Imipramine hydrochloride | 113-52-0 | 2A-9008026 |
| Ketoprofen lysinate | 57469-78-0 | 2A-9008083 |
| Browse all API & Advanced Intermediates products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS