CAS Number76420-72-9
SynonymsVasotec IV; MFCD08060099; ENALAPRILAT HYDRATE; L-Proline,1-[N-(1-carboxy-3-phenylpropyl)-L-alanyl]-,(S); S-1-[N-(1-carboxy-3-phenylpropyl)-L-alanyl]-L-proline; ENALAPRILAT USP(CRM STANDARD); Enalaprilat; Enalapril acid; Enalaprilic Acid; 1-[N-[(S)-1-Carboxy-3-phenylpropyl]-L-alanyl]-L-proline; N-(1(S)-carboxy-3-phenylpropyl)-L-alanyl-L-proline; enalaprilate; Enalapril diacid; EINECS 278-459-3
Molecular FormulaC18H24N2O5
Molecular Weight348.39
Purity≥98.0 (HPLC)%
Density1.286 g/cm3 (20ºC)
Boiling Point601ºC at 760 mmHg
Melting Point148-151°C
AppearanceWhite crystalline solid
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| Chemical & Physical Properties | |
|---|---|
| CAS Number | 76420-72-9 |
| Catalog No. | 2A-9007676 |
| Chinese Name | 依那普利拉 |
| Synonyms | Vasotec IV; MFCD08060099; ENALAPRILAT HYDRATE; L-Proline,1-[N-(1-carboxy-3-phenylpropyl)-L-alanyl]-,(S); S-1-[N-(1-carboxy-3-phenylpropyl)-L-alanyl]-L-proline; ENALAPRILAT USP(CRM STANDARD); Enalaprilat; Enalapril acid; Enalaprilic Acid; 1-[N-[(S)-1-Carboxy-3-phenylpropyl]-L-alanyl]-L-proline; N-(1(S)-carboxy-3-phenylpropyl)-L-alanyl-L-proline; enalaprilate; Enalapril diacid; EINECS 278-459-3 |
| Molecular Formula | C18H24N2O5 |
| Molecular Weight | 348.39 |
| Purity | ≥98.0 (HPLC) |
| Density | 1.286 g/cm3 (20ºC) |
| Boiling Point | 601ºC at 760 mmHg |
| Melting Point | 148-151°C |
| Appearance | White crystalline solid |
| Storage Condition | Store in a sealed container in a cool, dry place. |
| Application | Enalapril (MK-422 anhydrous) is the active metabolite of the oral prodrug enalapril and is a potent, competitive, long-acting angiotensin-converting enzyme (ACE) inhibitor with an IC50 of 1.94 nM. Ena |
| HTC | 2933990090 |
| PubChem ID | 329756327 |
| MDL Number | MFCD00865786 |
| SMILES | O=C(N1CCC[C@H]1C(O)=O)[C@H](C)N[C@H](C(O)=O)CCC2=CC=CC=C2 |
| InChI | 1S/C18H24N2O5/c1-12(16(21)20-11-5-8-15(20)18(24)25)19-14(17(22)23)10-9-13-6-3-2-4-7-13/h2-4,6-7,12,14-15,19H,5,8-11H2,1H3,(H,22,23)(H,24,25)/t12-,14-,15-/m0/s1 |
| InChI Key | LZFZMUMEGBBDTC-QEJZJMRPSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/7676_1_76420_72_9.pdf |
| Use of | Enalaprilat (MK-422 anhydrous), the active metabolite of the oral prodrug Enalapril, is a potent, competitive and long-acting angiotensin-converting enzyme (ACE) inhibitor, with an IC50 of 1.94 nM. Enalaprilat can be used for the research of hypertension[1][2][3]. Properties Name enalaprilat (anhydrous) Synonym More Synonyms Enalaprilat Biological Activity Description Enalaprilat (MK-422 anhydrous), the active metabolite of the oral prodrug Enalapril, is a potent, competitive and long-acting angiotensin-converting enzyme (ACE) inhibitor, with an IC50 of 1.94 nM. Enalaprilat can be used for the research of hypertension[1][2][3]. Related Catalog Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE) IC50: 1.94 nM (ACE)[1] In Vivo Enalaprilat (0.01%-2.9% in the eyedrop solution) shows significant intraocular pressure (IOP)-lowering effect in rabbits[3]. References [1]. Ceconi C, et, al. Angiotensin-converting enzyme (ACE) inhibitors have different selectivity for bradykinin binding sites of human somatic ACE. Eur J Pharmacol. 2007 Dec 22;577(1-3):1-6. [2]. Eickels M, et, al. Angiotensin-converting enzyme (ACE) inhibition attenuates insulin-like growth factor-I (IGF-I) induced cardiac fibroblast proliferation. Br J Pharmacol. 2000 Dec;131(8):1592-6. [3]. Loftsson T, et, al. Enalaprilat and enalapril maleate eyedrops lower intraocular pressure in rabbits. Acta Ophthalmol. 2010 May;88(3):337-41. Chemical & Physical Properties Molecular Formula C18H24N2O5 Exact Mass 348.16900 PSA 106.94000 LogP 1.45490 InChIKey LZFZMUMEGBBDTC-QEJZJMRPSA-N Safety Information Hazard Codes Xn Risk Phrases R68:Possible risk of irreversible effects. RTECS DU9085000 HS Code 2933990090 Synthetic Route 75847-73-3 Enalaprilat 76420-72-9 Literature: Iwasaki; Kimura; Numao; Kondo Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 2 p. 280 - 283 Enalapril malea... 76095-16-4 Enalaprilat 76420-72-9 Literature: Journal of Organic Chemistry, , vol. 49, # 15 p. 2816 - 2819 3-Phenylpropana... Enalaprilat 76420-72-9 Literature: Chemical and Pharmaceutical Bulletin, , vol. 37, # 2 p. 280 - 283 Precursor & DownStream Precursor 10 CAS#:75847-73-3 CAS#:76095-16-4 Enalapril maleate CAS#:104-53-0 3-Phenylpropanal CAS#:120379-81-9 5-phenylethyl-i... DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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