CAS Number191732-72-6
SynonymsLeflunomidum; Lenalidomide; 3-(4-amino-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione; Revimid; Leflunomide; 3-(4-Amino-1-oxo-1,3-dihydro-2H-isoindol-2-yl)-2,6-piperidinedione; Leflunomida; Arava; 3-(4-Amino-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidin-2,6-dion; lefunamide; Revlimid; IMiD3; HWA 486; Leflunomid
Molecular FormulaC13H13N3O3
Molecular Weight259.26
Purity≥98 (HPLC)%
Density1.5±0.1 g/cm3
Boiling Point614.0±55.0 °C at 760 mmHg
Melting Point269-271°C
Appearancepowder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 191732-72-6 |
| Catalog No. | 2A-9059561 |
| Chinese Name | 来那度胺 |
| Synonyms | Leflunomidum; Lenalidomide; 3-(4-amino-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione; Revimid; Leflunomide; 3-(4-Amino-1-oxo-1,3-dihydro-2H-isoindol-2-yl)-2,6-piperidinedione; Leflunomida; Arava; 3-(4-Amino-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidin-2,6-dion; lefunamide; Revlimid; IMiD3; HWA 486; Leflunomid |
| Molecular Formula | C13H13N3O3 |
| Molecular Weight | 259.26 |
| Purity | ≥98 (HPLC) |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 614.0±55.0 °C at 760 mmHg |
| Melting Point | 269-271°C |
| Appearance | powder |
| Water Solubility | Water solubility: insoluble; water solubility: 0.3 |
| Storage Condition | -20°C Freezer |
| Application | Lenalidomide is a TNF-α inhibitor used as an immunomodulatory drug. It also has anti-angiogenic activity. |
| HTC | 2925190090 |
| MDL Number | MFCD07772307 |
| SMILES | O=C1N(C2CCC(NC2=O)=O)CC3=C1C=CC=C3N |
| InChI | 1S/C13H13N3O3/c14-9-3-1-2-7-8(9)6-16(13(7)19)10-4-5-11(17)15-12(10)18/h1-3,10H,4-6,14H2,(H,15,17,18) |
| InChI Key | GOTYRUGSSMKFNF-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| MSDS | msds/59561_1_191732_72_6.pdf |
| Use of | Lenalidomide is a potent inhibitor of TNF-α used as a immunomodulatory drug. It has also been shown to have anti-angiogenic properties. Properties Name lenalidomide Synonym More Synonyms Lenalidomide (CC-5013) Biological Activity Description Lenalidomide is a potent inhibitor of TNF-α used as a immunomodulatory drug. It has also been shown to have anti-angiogenic properties. Related Catalog Signaling Pathways >> Apoptosis >> TNF Receptor Research Areas >> Cancer References [1]. Omran A, et al. Effects of MRP8, LPS, and lenalidomide on the expressions of TNF-α , brain-enriched, and inflammation-related microRNAs in the primary astrocyte culture. ScientificWorldJournal. 2013 Sep 21;2013:208309. [2]. Kotla V, et al. Mechanism of action of lenalidomide in hematological malignancies. J Hematol Oncol. 2009 Aug 12;2:36. [3]. Lopez-Girona A, et al. Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide. Leukemia. 2012 Nov;26(11):2326-35. [4]. Rozewski DM, et al. Pharmacokinetics and tissue disposition of lenalidomide in mice. AAPS J. 2012 Dec;14(4):872-82. [6]. Nagashima, Takeyuki, et al. PHARMACEUTICAL COMPOSITION COMPRISING BICYCLIC NITROGEN-CONTAINING AROMATIC HETEROCYCLIC AMIDE COMPOUND AS ACTIVE INGREDIENT. Patent. 20170360780A1. Chemical & Physical Properties Molecular Formula C13H13N3O3 Exact Mass 259.095703 PSA 92.50000 LogP -1.39 Index of Refraction 1.672 InChIKey GOTYRUGSSMKFNF-UHFFFAOYSA-N Safety Information Hazard Codes Xi Safety Phrases S26-S36 WGK Germany 3 HS Code 2925190090 |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 30.0% |
| Transport Info | Product name: Summary 2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |
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