CAS Number72-69-5
SynonymsSesaval; Lumbeck; NORTRIPTYLINE; Ateben; noramitriptyline; Noritren; allegron; desmethylamitriptyline; lambeck; EINECS 200-788-8; Aventyl; Psychostyl; notriptyline; Avantyl
Molecular FormulaC19H21N
Molecular Weight263.37700
Density1.084 g/cm3
Boiling Point403.4ºC at 760 mmHg
Appearancewhite solid
EINECS200-788-8
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 72-69-5 |
| Catalog No. | 2A-9059585 |
| Chinese Name | 去甲替林 |
| Synonyms | Sesaval; Lumbeck; NORTRIPTYLINE; Ateben; noramitriptyline; Noritren; allegron; desmethylamitriptyline; lambeck; EINECS 200-788-8; Aventyl; Psychostyl; notriptyline; Avantyl |
| Molecular Formula | C19H21N |
| Molecular Weight | 263.37700 |
| Density | 1.084 g/cm3 |
| Boiling Point | 403.4ºC at 760 mmHg |
| Appearance | white solid |
| Storage Condition | 2-8°C |
| Application | Nortriptyline (desmethylamitriptyline), the main active metabolite of amitriptyline, is a tricyclic antidepressant used to relieve symptoms of depression. Nortriptyline is a potent autophagy inhibitor |
| EINECS | 200-788-8 |
| HTC | 2921499090 |
| SMILES | CNCCC=C1c2ccccc2CCc2ccccc21 |
| InChI | InChI=1S/C19H21N/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19/h2-5,7-11,20H,6,12-14H2,1H3 |
| InChI Key | PHVGLTMQBUFIQQ-UHFFFAOYSA-N |
| MSDS | msds/59585_1_72_69_5.pdf |
| Use of | Nortriptyline (Desmethylamitriptyline), the main active metabolite of Amitriptyline, is a tricyclic antidepressant used to relieve the symptoms of depression. Nortriptyline is a potent autophagy inhibitor[1][2]. Properties Name nortriptyline Synonym More Synonyms Nortriptyline Biological Activity Description Nortriptyline (Desmethylamitriptyline), the main active metabolite of Amitriptyline, is a tricyclic antidepressant used to relieve the symptoms of depression. Nortriptyline is a potent autophagy inhibitor[1][2]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Neurological Disease References Chemical & Physical Properties Molecular Formula C19H21N Exact Mass 263.16700 PSA 12.03000 LogP 4.21730 Index of Refraction 1.633 InChIKey PHVGLTMQBUFIQQ-UHFFFAOYSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : 5H-Dibenzo(a,d)cycloheptene-delta(sup 5),gamma-propylamine, 10,11-dihydro-N-methyl- CAS REGISTRY NUMBER : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : MOLECULAR WEIGHT : WISWESSER LINE NOTATION : L C676 BY&T&J BU3M1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Behavioral - muscle weakness Behavioral - ataxia Behavioral - muscle contraction or spasticity REFERENCE : HEPHD2 Handbook of Experimental Pharmacology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.50- 1978- Volume(issue)/page/year: 55,527,1980 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Behavioral - muscle weakness Behavioral - ataxia Behavioral - muscle contraction or spasticity REFERENCE : HEPHD2 Handbook of Experimental Pharmacology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.50- 1978- Volume(issue)/page/year: 55,527,1980 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 20,1561,1970 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 6,338,1963 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Behavioral - changes in motor activity (specific assay) REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 17,65,1974 *** REVIEWS *** TOXICOLOGY REVIEW DICPBB Drug Intelligence and Clinical Pharmacy. (POB 42435, Cincinnati, OH 45242) V.3- 1969- Volume(issue)/page/year: 8,690,1974 TOXICOLOGY REVIEW CLCHAU Clinical Chemistry (Winston-Salem, NC). (American Assoc. for Clinical Chemistry, 1725 K St., NW, Washington, DC 20006) V.1- 1955- Volume(issue)/page/year: 19,361,1973 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4842 No. of Facilities: 25 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 2440 (estimated) No. of Female Employees: 1459 (estimated) Safety Information HS Code 2921499090 Synthetic Route Desmethylnortri... methyl iodide Nortriptyline Amitriptyline Nortriptyline Literature: Journal of the Indian Chemical Society, , vol. 62, # 11 p. 899 - 903 Ethyl [3-(10,11... 16234-88-1 Nortriptyline Literature: Collection of Czechoslovak Chemical Communications, , vol. 32, # 8 p. 2826 - 2839 Precursor & DownStream Precursor 9 CAS#:4444-42-2 Desmethylnortri... CAS#:74-88-4 methyl iodide CAS#:50-48-6 Amitriptyline CAS#:16234-88-1 Ethyl [3-(10,11... DownStream 4 CAS#:50-48-6 Amitriptyline CAS#:4444-42-2 Desmethylnortri... CAS#:47132-19-4 (Z)-10-Hydroxy ... CAS#:47132-16-1 (E)-10-Hydroxyn... |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 30.0% |
| Transport Info | Product name: Summary 2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |
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