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Home > Products > Pharmaceuticals & Life Science > API & Advanced Intermediates > R(+)-Verapamil monohydrochloride hydrate
R(+)-Verapamil monohydrochloride hydrate structure, CAS 38176-02-2

R(+)-Verapamil monohydrochloride hydrate

CAS Number38176-02-2

Synonyms(+)-[3-cyano-3-(3,4-dimethoxyphenyl)hex-6-yl](5,6-dimethoxyphenethyl)methylammonium chloride

Molecular FormulaC27H39ClN2O4

Molecular Weight491.06 (anhydrous basis)

Purity≥98 (HPLC)%

Density

Boiling Point

Melting Point129-131℃

Flash Point

Appearancepowder

EINECS205-800-5

MSDSChineseEnglish

Symboltransportation

Signal WordWarning

Cat. No.: 2A-9059547 Purity: ≥98 (HPLC)%
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Quality Control of [ 38176-02-2 ] Purity: ≥98 (HPLC)% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number38176-02-2
Catalog No.2A-9059547
Chinese Name(R)-Verapamil hydrochloride
Synonyms(+)-[3-cyano-3-(3,4-dimethoxyphenyl)hex-6-yl](5,6-dimethoxyphenethyl)methylammonium chloride
Molecular FormulaC27H39ClN2O4
Molecular Weight491.06 (anhydrous basis)
Purity≥98 (HPLC)
Melting Point129-131℃
Appearancepowder
Storage Condition2-8℃, sealed, dry
Application(R)-Verapamil hydrochloride ((R)-(+)-Verapamil hydrochloride) is a P-glycoprotein inhibitor. (R)-Verapamil hydrochloride inhibits MRP1-mediated transport, resulting in chemosensitivity of MRP1-overexp
EINECS205-800-5
PubChem ID24900706
MDL NumberMFCD11046028
SMILESO.Cl.COc1ccc(CCN(C)CCC[C@@](C#N)(C(C)C)c2ccc(OC)c(OC)c2)cc1OC
InChI1S/C27H38N2O4.ClH.H2O/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;;/h9-12,17-18,20H,8,13-16H2,1-7H3;1H;1H2/t27-;;/m1../s1
InChI KeyICKXRKHJKXMFLR-KFSCGDPASA-N
NACRES CodeNA.77
UNSPSC12161501
Hazard Symbolstransportation
MSDSmsds/59547_1_38176_02_2.pdf
Bioactivity(R)-Verapamil hydrochloride ((R)-(+)-Verapamil hydrochloride) is a P-Glycoprotein inhibitor. (R)-Verapamil hydrochloride blocks MRP1 mediated transport, resulting in chemosensitization of MRP1-overexpressing cells to anticancer drugs[1][2]. Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Membrane Transporter/Ion Channel >> P-glycoprotein References [1]. Plumb JA, et al. The activity of verapamil as a resistance modifier in vitro in drug resistant human tumour cell lines is not stereospecific. Biochem Pharmacol. 1990 Feb 15;39(4):787-92. [2]. Perrotton T, et al. (R)- and (S)-verapamil differentially modulate the multidrug-resistant protein MRP1. J Biol Chem. 2007 Oct 26;282(43):31542-8. Epub 2007 Jul 22. Chemical & Physical Properties Melting Point 129-131℃ Molecular Formula C27H39ClN2O4 Molecular Weight 477.03600 Exact Mass 476.24400 PSA 65.15000 LogP 0.43398 InChIKey DOQPXTMNIUCOSY-HZPIKELBSA-N SMILES COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC.Cl
Use ofProperties Name R(+)-Verapamil monohydrochloride hydrate Synonym More Synonyms (R)-Verapamil hydrochloride Biological Activity Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Membrane Transporter/Ion Channel >> P-glycoprotein References [1]. Plumb JA, et al. The activity of verapamil as a resistance modifier in vitro in drug resistant human tumour cell lines is not stereospecific. Biochem Pharmacol. 1990 Feb 15;39(4):787-92. [2]. Perrotton T, et al. (R)- and (S)-verapamil differentially modulate the multidrug-resistant protein MRP1. J Biol Chem. 2007 Oct 26;282(43):31542-8. Epub 2007 Jul 22. Chemical & Physical Properties Exact Mass 476.24400 PSA 65.15000 LogP 0.43398 InChIKey DOQPXTMNIUCOSY-HZPIKELBSA-N
Transport InfoShipping Name: UN
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Dangerous Regulations for land transport: 2811 International Dangerous Regulations for sea transport: 2811 International Dangerous Regulations for air transport: 2811 14.2 United Nations shipping name European Land Transport Dangerous Regulations: TOXIC SOLID, ORGANIC, N.O.S. (Verapamil monohydrochloride hydrate) IMDG Code: TOXIC SOLID, ORGANIC, N.O.S. (Verapamil monohydrochloride hydrate) International air transport hazard regulations: Toxic solid, organic, n.o.s. (Verapamil monohydrochloride hydrate) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available
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