| Chemical & Physical Properties | |
|---|---|
| CAS Number | 871038-72-1 |
| Catalog No. | 2A-9058636 |
| Chinese Name | 雷特格韦钾盐 |
| Synonyms | Raltegravir (potassium salt); MK 0518; Raltegravir K; Raltegravir(MK-0518); Raltegravirpotassium |
| Molecular Formula | C20H20FKN6O5 |
| Molecular Weight | 482.51 |
| Purity | 98.00 |
| Density | 1.46 g/cm3 |
| Melting Point | 282ºC |
| Appearance | solid |
| Storage Condition | -20°C Freezer |
| Application | Raltegravir potassium salt is a potent integrase inhibitor used to treat HIV infection. |
| HTC | 2934999090 |
| PubChem ID | 329796542 |
| MDL Number | MFCD12031642 |
| SMILES | CN1C(C([O-])=C(C(NCC2=CC=C(C=C2)F)=O)N=C1C(C)(NC(C3=NN=C(O3)C)=O)C)=O.[K+] |
| InChI | 1S/C20H21FN6O5.K/c1-10-25-26-17(32-10)16(30)24-20(2,3)19-23-13(14(28)18(31)27(19)4)15(29)22-9-11-5-7-12(21)8-6-11;/h5-8,28H,9H2,1-4H3,(H,22,29)(H,24,30);/q;+1/p-1 |
| InChI Key | IFUKBHBISRAZTF-UHFFFAOYSA-M |
| NACRES Code | NA.21 |
| UNSPSC | 12352200 |
| MSDS | msds/58636_1_871038_72_1.pdf |
| Use of | Raltegravir (potassium salt) is a potent integrase (IN) inhibitor, used to treat HIV infection. Properties Name Raltegravir potassium Synonym More Synonyms Raltegravir (potassium salt) Biological Activity Description Raltegravir (potassium salt) is a potent integrase (IN) inhibitor, used to treat HIV infection. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> HIV Integrase Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection In Vivo Raltegravir induces viro-immunological improvement of nonhuman primates with progressing SIVmac251 infection. One non-human primate shows an undetectable viral load following Raltegravir monotherapy[5]. References [1]. Hare, S., et al., Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance. Proc Natl Acad Sci U S A, 2010. 107(46): p. 20057-62. [2]. Hicks C, et al. Raltegravir: the first HIV type 1 integrase inhibitor. Clin Infect Dis. 2009 Apr 1;48(7):931-9. [3]. Moss DM, et al. Divalent metals and pH alter raltegravir disposition in vitro. Antimicrob Agents Chemother. 2012 Jun;56(6):3020-6. [4]. Hare S, et al. Structural and functional analyses of the second-generation integrase strand transfer inhibitor dolutegravir (S/GSK1349572). Mol Pharmacol. 2011 Oct;80(4):565-72. [5]. Lewis, M.G., et al. Response of a simian immunodeficiency virus (SIVmac251) to raltegravir: a basis for a new treatment for simian AIDS and an animal model for studying lentiviral persistence during antiretroviral therapy. Retrovirology, 2010. 7: p. 21. Chemical & Physical Properties Molecular Formula C20H20FKN6O5 Exact Mass 482.111633 PSA 155.07000 LogP 2.13150 InChIKey IFUKBHBISRAZTF-UHFFFAOYSA-M Safety Information HS Code 2934999090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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