CAS Number755037-03-7
SynonymsBAY734506; Regorafenib; 4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-N-methylpicolinamide; Stivarga; BAY73-4506; BAY 73-4506
Molecular FormulaC21H15O3N4Cl1F4
Molecular Weight482.82
Purity98.00%
Density1.5±0.1 g/cm3
Boiling Point513.4±50.0 °C at 760 mmHg
Melting Point206.0 to 210.0 °C
AppearanceSolid;White to Light yellow to Light orange powder to crystal
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 755037-03-7 |
| Catalog No. | 2A-9058087 |
| Chinese Name | 瑞格非尼 |
| Synonyms | BAY734506; Regorafenib; 4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-N-methylpicolinamide; Stivarga; BAY73-4506; BAY 73-4506 |
| Molecular Formula | C21H15O3N4Cl1F4 |
| Molecular Weight | 482.82 |
| Purity | 98.00 |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 513.4±50.0 °C at 760 mmHg |
| Melting Point | 206.0 to 210.0 °C |
| Appearance | Solid;White to Light yellow to Light orange powder to crystal |
| Storage Condition | <0°C; avoid heating |
| Application | Regorafenib (BAY 73-4506) is a multi-target receptor tyrosine kinase inhibitor that inhibits VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1 with IC50s of 13/4.2/46, 22, 7, 1.5 and 2.5 nM respectively. |
| HTC | 29242990 |
| MDL Number | MFCD16038047 |
| SMILES | CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)c(F)c2)ccn1 |
| InChI Key | FNHKPVJBJVTLMP-UHFFFAOYSA-N |
| MSDS | msds/58087_1_755037_03_7.pdf |
| Transport Info | Product name: Regorafenib |
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