CAS Number474-58-8
Synonymsβ-D-Glucopyranoside, (3β)-stigmast-5-en-3-yl; Daucosterin; lyoniside; Coriandrinol; (3b)-Stigmast-5-en-3-yl b-D-Glucopyranoside; Sitogluside; β-Sitosterol β-D-glucoside; β-sitosterol-D-glucoside; b-Daucosterol; b-Sitosteryl glucoside; Alexandrin; Eleutheroside A; β-sitosterol 3-O-β-D-glucopyranoside; 1513DMIa; Sterolin; β-sitosteryl-β-D-glucopyranoside; 3b-(b-D-glucopyranosyloxy)stigmast-5-ene; Doursterol; (3β)-Stigmast-5-en-3-yl β-D-glucopyranoside; 3β-(β-D-Glucopyranosyloxy)stigmast-5-ene; BSSG; β-Sitosteryl glucoside; 3-β-D-glucosylsitosterol; 3-β-(β-D-Glucopyranosyloxy)stigmast-5-ene
Molecular FormulaC35H60O6
Molecular Weight576.85
Purity≥75.0 (HPLC)%
Density1.1±0.1 g/cm3
Boiling Point673.6±55.0 °C at 760 mmHg
Appearanceoff-white powder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 474-58-8 |
| Catalog No. | 2A-9022103 |
| Chinese Name | 胡萝卜苷 |
| Synonyms | β-D-Glucopyranoside, (3β)-stigmast-5-en-3-yl; Daucosterin; lyoniside; Coriandrinol; (3b)-Stigmast-5-en-3-yl b-D-Glucopyranoside; Sitogluside; β-Sitosterol β-D-glucoside; β-sitosterol-D-glucoside; b-Daucosterol; b-Sitosteryl glucoside; Alexandrin; Eleutheroside A; β-sitosterol 3-O-β-D-glucopyranoside; 1513DMIa; Sterolin; β-sitosteryl-β-D-glucopyranoside; 3b-(b-D-glucopyranosyloxy)stigmast-5-ene; Doursterol; (3β)-Stigmast-5-en-3-yl β-D-glucopyranoside; 3β-(β-D-Glucopyranosyloxy)stigmast-5-ene; BSSG; β-Sitosteryl glucoside; 3-β-D-glucosylsitosterol; 3-β-(β-D-Glucopyranosyloxy)stigmast-5-ene |
| Molecular Formula | C35H60O6 |
| Molecular Weight | 576.85 |
| Purity | ≥75.0 (HPLC) |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 673.6±55.0 °C at 760 mmHg |
| Appearance | off-white powder |
| Storage Condition | 2-8°C |
| Application | Daucosterol is a natural sterol compound. |
| HTC | 29389090 |
| MDL Number | MFCD01683621 |
| SMILES | CC[C@H](CC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@H](CC[C@]4(C)[C@H]3CC[C@]12C)O[C@@H]5OC(CO)[C@@H](O)[C@H](O)C5O)C(C)C |
| InChI | 1S/C35H60O6/c1-7-22(20(2)3)9-8-21(4)26-12-13-27-25-11-10-23-18-24(14-16-34(23,5)28(25)15-17-35(26,27)6)40-33-32(39)31(38)30(37)29(19-36)41-33/h10,20-22,24-33,36-39H,7-9,11-19H2,1-6H3/t21-,22-,24+,25+,26-,27+,28+,29-,30-,31+,32-,33-,34+,35-/m1/s1 |
| InChI Key | NPJICTMALKLTFW-OFUAXYCQSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 85151701 |
| Hazard Symbols | Transport |
| MSDS | msds/22103_1_474_58_8.pdf |
| Bioactivity | Daucosterol is a natural sterolin. IC50 value:Target:In vitro: In the study of the effects of daucosterol on the survival of cultured cortical neurons after neurons were subjected to oxygen and glucose deprivation and simulated reperfusion (OGD/R)(2), the results showed that post-treatment of daucosterol significantly reduced neuronal loss, as well as apoptotic rate and caspase-3 activity, displaying the neuroprotective activity. We also found that daucosterol increased the expression level of IGF1 protein, diminished the down-regulation of p-AKT(3) and p-GSK-3β(4), thus activating the AKT(5) signal pathway [1]. Cell counting kit-8 (CCK-8) assay showed that daucosterol significantly increased the quantity of viable cells and the effectiveness of daucosterol was similar to that of basic fibroblast growth factor (bFGF) and epidermal growth factor (EGF) [2]. Daucosterol inhibits the proliferation of human breast cancer cell line MCF-7 and gastric cancer cell lines MGC803, BGC823 and AGS in a dose-dependent manner. Furthermore, daucosterol inhibits murine hepatoma H22 cell growth in ICR mice. Daucosterol treatment induces intracellular ROS generation and autophagy, but not apoptotic cell death. Treatment with ROS scavenger GSH (reduced glutathione), NAC (N-acetyl-l-cysteine) or autophagy inhibitor 3-Methyladenine (3-MA) counteracted daucosterol-induced autophagy and growth inhibition in BGC823 and MCF-7 cancer cells [3].In vivo: Related Catalog Signaling Pathways >> Others >> Others Natural Products >> Steroids Research Areas >> Cancer References [1]. Jiang LH, et al. Daucosterol protects neurons against oxygen-glucose deprivation/reperfusion-mediated injury by activating IGF1 signaling pathway. J Steroid Biochem Mol Biol. 2015 Aug;152:45-52. [2]. Jiang LH, et al. Daucosterol promotes the proliferation of neural stem cells. J Steroid Biochem Mol Biol. 2014 Mar;140:90-9. [3]. Zhao C, et al. Daucosterol inhibits cancer cell proliferation by inducing autophagy through reactive oxygen species-dependent manner. Life Sci. 2015 Sep 15;137:37-43. Chemical & Physical Properties Density 1.1±0.1 g/cm3 Boiling Point 673.6±55.0 °C at 760 mmHg Molecular Formula C35H60O6 Molecular Weight 576.847 Flash Point 361.2±31.5 °C Exact Mass 576.438965 PSA 99.38000 LogP 8.78 Vapour Pressure 0.0±4.7 mmHg at 25°C Index of Refraction 1.554 InChIKey NPJICTMALKLTFW-OFUAXYCQSA-N SMILES CCC(CCC(C)C1CCC2C3CC=C4CC(OC5OC(CO)C(O)C(O)C5O)CCC4(C)C3CCC12C)C(C)C Storage condition 2-8°C |
| Use of | Properties Articles26 Name Daucosterol Synonym More Synonyms Daucosterol Biological Activity Related Catalog Signaling Pathways >> Others >> Others Natural Products >> Steroids Research Areas >> Cancer References [1]. Jiang LH, et al. Daucosterol protects neurons against oxygen-glucose deprivation/reperfusion-mediated injury by activating IGF1 signaling pathway. J Steroid Biochem Mol Biol. 2015 Aug;152:45-52. [2]. Jiang LH, et al. Daucosterol promotes the proliferation of neural stem cells. J Steroid Biochem Mol Biol. 2014 Mar;140:90-9. [3]. Zhao C, et al. Daucosterol inhibits cancer cell proliferation by inducing autophagy through reactive oxygen species-dependent manner. Life Sci. 2015 Sep 15;137:37-43. Chemical & Physical Properties Molecular Formula C35H60O6 Exact Mass 576.438965 PSA 99.38000 Index of Refraction 1.554 InChIKey NPJICTMALKLTFW-OFUAXYCQSA-N |
| Transport Info | Product name: Purity: 96.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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