CAS Number480-18-2
SynonymsEINECS 207-543-4; Dihydroquercetin; (3R)-2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydro-4H-chromen-4-one; (2R,3R)-3,3',4',5,7-Pentahydroxyflavanone; Distylin; (+)-Taxifolin; (2S,3S)-2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydro-4H-chromen-4-one; Taxifolin; MFCD00006845; (-)-taxifolin; Taxifoliol; (2R,3R)-2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydro-4H-chromen-4-one
Molecular FormulaC15H12O7
Molecular Weight304.25
Purity≥85 (HPLC)%
Density1.7±0.1 g/cm3
Boiling Point687.6±55.0 °C at 760 mmHg
Melting Point230-233°C (dec.)
AppearanceLight yellow powder
EINECS207-543-4
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 480-18-2 |
| Catalog No. | 2A-9022136 |
| Chinese Name | 花旗松素 |
| Synonyms | EINECS 207-543-4; Dihydroquercetin; (3R)-2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydro-4H-chromen-4-one; (2R,3R)-3,3',4',5,7-Pentahydroxyflavanone; Distylin; (+)-Taxifolin; (2S,3S)-2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydro-4H-chromen-4-one; Taxifolin; MFCD00006845; (-)-taxifolin; Taxifoliol; (2R,3R)-2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydro-4H-chromen-4-one |
| Molecular Formula | C15H12O7 |
| Molecular Weight | 304.25 |
| Purity | ≥85 (HPLC) |
| Density | 1.7±0.1 g/cm3 |
| Boiling Point | 687.6±55.0 °C at 760 mmHg |
| Melting Point | 230-233°C (dec.) |
| Appearance | Light yellow powder |
| Storage Condition | Store in a sealed container in a ventilated and dr |
| Application | Taxifolin has important antityrosinase activity. Taxifolin effectively inhibits collagenase with an IC50 of 193.3 μM. |
| EINECS | 207-543-4 |
| HTC | 2932999099 |
| PubChem ID | 329768169 |
| MDL Number | MFCD00006845 |
| SMILES | O[C@@H]1[C@H](Oc2cc(O)cc(O)c2C1=O)c3ccc(O)c(O)c3 |
| InChI | 1S/C15H12O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,14-19,21H/t14-,15+/m0/s1 |
| InChI Key | CXQWRCVTCMQVQX-LSDHHAIUSA-N |
| Beilstein/REAXYS | 5299277 |
| NACRES Code | NA.24 |
| UNSPSC | 85151701 |
| Hazard Symbols | Transport |
| MSDS | msds/22136_1_480_18_2.pdf |
| Bioactivity | Taxifolin exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM. Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Metabolic Enzyme/Protease >> Tyrosinase Research Areas >> Cancer Natural Products >> Flavonoids Target IC50: 193.3 μM (Collagenase)[1] Tyrosinase[1] In Vitro This is confirmed by the investigation of pure Taxifolin and (+)-Catechin against collagenase activity. Taxifolin exhibits significant inhibitory activity with an IC50 value of 193.3 μM while (+)-Catechin is not active[1]. Taxifolin is a ubiquitous bioactive constituent of foods and herbs. Taxifolin (dihydroquercetin) is a bioactive flavanonol commonly found in grapes, citrus fruits, onions, green tea, olive oil, wine, and many other foods, as well as several herbs (such as milk thistle, French maritime bark, Douglas fir bark, and Smilacis Glabrae Rhizoma)[2]. In Vivo Taxifolin may be easily metabolized and that its metabolites are the prevalent form in vivo, although limited information is available on metabolism of Taxifolin in vivo[2]. Animal Admin Rats[2] Twelve male Sprague-Dawley rats (weighing 180-220 g) are used. The rats are randomly divided into two groups (six rats per group), a drug group and a blank group. Taxifolin is suspended in 0.5% CMC-Na solution and orally administered to the drug group at a dose of 200 mg/kg body weight, while blank group rats are orally administered 0.5% CMC-Na solution at the same volume. All rats are dosed once a day (at 9:00 a.m.) for 3 days. References [1]. Angelis A, et al. Bio-Guided Isolation of Methanol-Soluble Metabolites of Common Spruce (Picea abies) Bark by-Products and Investigation of Their Dermo-Cosmetic Properties. Molecules. 2016 Nov 21;21(11). pii: E1586. [2]. Yang P, et al. Detection of 191 Taxifolin Metabolites and Their Distribution in Rats Using HPLC-ESI-IT-TOF-MS(n). Molecules. 2016 Sep 13;21(9). pii: E1209. Chemical & Physical Properties Density 1.7±0.1 g/cm3 Boiling Point 687.6±55.0 °C at 760 mmHg Melting Point 230-233°C (dec.) Molecular Formula C15H12O7 Molecular Weight 304.252 Flash Point 264.2±25.0 °C Exact Mass 304.058289 PSA 127.45000 LogP 1.82 Vapour Pressure 0.0±2.3 mmHg at 25°C Index of Refraction 1.763 InChIKey CXQWRCVTCMQVQX-LSDHHAIUSA-N SMILES O=C1c2c(O)cc(O)cc2OC(c2ccc(O)c(O)c2)C1O Storage condition -20?C Freezer |
| Use of | Taxifolin exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM. Properties Articles36 Name (+)-taxifolin Synonym More Synonyms Taxifolin Biological Activity Description Taxifolin exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM. Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Metabolic Enzyme/Protease >> Tyrosinase Research Areas >> Cancer Natural Products >> Flavonoids IC50: 193.3 μM (Collagenase)[1] Tyrosinase[1] In Vitro This is confirmed by the investigation of pure Taxifolin and (+)-Catechin against collagenase activity. Taxifolin exhibits significant inhibitory activity with an IC50 value of 193.3 μM while (+)-Catechin is not active[1]. Taxifolin is a ubiquitous bioactive constituent of foods and herbs. Taxifolin (dihydroquercetin) is a bioactive flavanonol commonly found in grapes, citrus fruits, onions, green tea, olive oil, wine, and many other foods, as well as several herbs (such as milk thistle, French maritime bark, Douglas fir bark, and Smilacis Glabrae Rhizoma)[2]. In Vivo Taxifolin may be easily metabolized and that its metabolites are the prevalent form in vivo, although limited information is available on metabolism of Taxifolin in vivo[2]. References [1]. Angelis A, et al. Bio-Guided Isolation of Methanol-Soluble Metabolites of Common Spruce (Picea abies) Bark by-Products and Investigation of Their Dermo-Cosmetic Properties. Molecules. 2016 Nov 21;21(11). pii: E1586. [2]. Yang P, et al. Detection of 191 Taxifolin Metabolites and Their Distribution in Rats Using HPLC-ESI-IT-TOF-MS(n). Molecules. 2016 Sep 13;21(9). pii: E1209. Chemical & Physical Properties Molecular Formula C15H12O7 Exact Mass 304.058289 PSA 127.45000 Index of Refraction 1.763 InChIKey CXQWRCVTCMQVQX-LSDHHAIUSA-N Storage condition -20?C Freezer |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
| Related Products in Botanical Reference Standards | ||
|---|---|---|
| Arjunolic acid | 465-00-9 | 2A-9022069 |
| Hederagenin | 465-99-6 | 2A-9022074 |
| alpha-Boswellic acid | 471-66-9 | 2A-9022092 |
| Daucosterol | 474-58-8 | 2A-9022103 |
| Rhein | 478-43-3 | 2A-9022121 |
| Linarin | 480-36-4 | 2A-9022138 |
| Chrysin | 480-40-0 | 2A-9022140 |
| Aloe-emodin | 481-72-1 | 2A-9022157 |
| Kaempferitrin | 482-38-2 | 2A-9022161 |
| Afzelin | 482-39-3 | 2A-9022162 |
| Browse all Botanical Reference Standards products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS