CAS Number478-43-3
SynonymsRhein; 1,8-dihydroxy-3-carboxy-9,10-anthraquinone; EINECS 207-521-4; Cassic acid; Rheic acid; Rhubarb Yellow; 1,8-dihydroxyanthraquinone-3-carboxylic acid; 1,8-dihydroxy-3-carboxyanthraquinone; 9,10-Dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylic acid; MFCD00009618; Monorhein; 4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid; 4,5-Dihydroxy-9,10-dioxo-9,10-dihydro-2-anthracenecarboxylic acid; 4,5-Dihydroxyanthraquinone-2-carboxylic acid; 9,10-dihydro-4,5-dihydroxy-9,10-dioxoanthracene-2-carboxylic acid; Chrysazin-3-carboxylic acid
Molecular FormulaC15H8O6
Molecular Weight284.22
Purity98.00%
Density1.7±0.1 g/cm3
Boiling Point597.8±50.0 °C at 760 mmHg
Melting Point≥300 °C (lit.)
AppearanceIt is brown needle crystal, and turns into yellow needle crystal after sublimation. Melting point 32
EINECS207-521-4
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 478-43-3 |
| Catalog No. | 2A-9022121 |
| Chinese Name | 大黄酸 |
| Synonyms | Rhein; 1,8-dihydroxy-3-carboxy-9,10-anthraquinone; EINECS 207-521-4; Cassic acid; Rheic acid; Rhubarb Yellow; 1,8-dihydroxyanthraquinone-3-carboxylic acid; 1,8-dihydroxy-3-carboxyanthraquinone; 9,10-Dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylic acid; MFCD00009618; Monorhein; 4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid; 4,5-Dihydroxy-9,10-dioxo-9,10-dihydro-2-anthracenecarboxylic acid; 4,5-Dihydroxyanthraquinone-2-carboxylic acid; 9,10-dihydro-4,5-dihydroxy-9,10-dioxoanthracene-2-carboxylic acid; Chrysazin-3-carboxylic acid |
| Molecular Formula | C15H8O6 |
| Molecular Weight | 284.22 |
| Purity | 98.00 |
| Density | 1.7±0.1 g/cm3 |
| Boiling Point | 597.8±50.0 °C at 760 mmHg |
| Melting Point | ≥300 °C (lit.) |
| Appearance | It is brown needle crystal, and turns into yellow needle crystal after sublimation. Melting point 32 |
| Water Solubility | <0.1 g/100 mL at 17 ºC |
| Storage Condition | Sealed and stored in a cool, dry warehouse. |
| Application | Rhein is an anthraquinone compound with anti-inflammatory, antioxidant, and anti-cancer effects. |
| EINECS | 207-521-4 |
| HTC | 2918990090 |
| PubChem ID | 24856659 |
| MDL Number | MFCD00009618 |
| SMILES | OC(=O)c1cc(O)c2C(=O)c3c(O)cccc3C(=O)c2c1 |
| InChI | 1S/C15H8O6/c16-9-3-1-2-7-11(9)14(19)12-8(13(7)18)4-6(15(20)21)5-10(12)17/h1-5,16-17H,(H,20,21) |
| InChI Key | FCDLCPWAQCPTKC-UHFFFAOYSA-N |
| Beilstein/REAXYS | 2222155 |
| NACRES Code | NA.22 |
| UNSPSC | 12352100 |
| MSDS | msds/22121_1_478_43_3.pdf |
| Use of | Properties Articles189 Name Rhein Synonym More Synonyms Rhein Biological Activity Related Catalog Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Cancer Natural Products >> Quinones Research Areas >> Inflammation/Immunology Research Areas >> Infection References [1]. Xiaowen Chen, et al. Toll-like receptor 4 is involved in a protective effect of rhein on immunoglobulin A nephropathy. Indian J Pharmacol. 2015 Jan-Feb; 47(1): 27-33. [2]. Hou ML, et al. The Drug-Drug Effects of Rhein on the Pharmacokinetics and Pharmacodynamics of Clozapine in Rat Brain Extracellular Fluid by In Vivo Microdialysis. J Pharmacol Exp Ther. 2015 Oct;355(1):125-34. [3]. Yan-Xi Zhou, et al. Rhein: A Review of Pharmacological Activities. Evid Based Complement Alternat Med. 2015; 2015: 578107. Chemical & Physical Properties Molecular Formula C15H8O6 Exact Mass 284.032074 PSA 111.90000 Index of Refraction 1.761 Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : 2-Anthracenecarboxylic acid, 9,10-dihydro-4,5-dihydroxy-9,10-dioxo- CAS REGISTRY NUMBER : BEILSTEIN REFERENCE NO. : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : MOLECULAR WEIGHT : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : Safety Information Signal Word Warning Hazard Statements H315-H319-H335 Precautionary Statements P305 + P351 + P338 Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves Hazard Codes Xi RIDADR NONH for all modes of transport WGK Germany 2 RTECS CA9516000 HS Code 2918990090 Synthetic Route 13739-02-1 Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 7, # 7 p. 817 - 822 Chrysophanic ac... Literature: EP1913940 A1, ; Page/Page column 10 ; rhein potassium 1402610-53-0 Literature: EP2196450 A1, ; Page/Page column 6-7 ; Precursor & DownStream Precursor 9 CAS#:13739-02-1 CAS#:481-74-3 Chrysophanic acid CAS#:1402610-53-0 rhein potassium CAS#:481-72-1 Aloeemodin DownStream 3 CAS#:117-10-2 CAS#:13739-02-1 CAS#:72049-24-2 4,5-dimethoxy-9... |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Summary 2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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