CAS Number378-44-9
Synonyms16β-Methyl-1,4-pregnadiene-9α-fluoro-11β,17α,21-triol-3,20-dione; Bifas; Betasolon; Betadexamethasone; Celestene; Flubenisolone; Visubeta; 9A-FLUORO-16β-METHYLPREDNISOLONE; 9α-Fluoro-11β,17α,21-trihydroxy-16β-methyl-1,4-pregnadiene-3,20-dione; b-Methasone alcohol; Bebate; EINECS 206-825-4; 16b-Methyl-9a-fluoroprednisolone; Celestone; betamethazone; (11b,16b)-9-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione; 9α-Fluoro-16β-methylprednisolone; Betametasona [INN-Spanish]; Betnelan; b-Methasone; β-Methasone; Betametasone [DCIT]; DERMABET; Pertene; β-Methasone alcohol; MFCD00062969; Betsolan; (11β,16β)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione; 4-08-00-03501 (Beilstein Handbook Reference); Diprolene
Molecular FormulaC22H29FO5
Molecular Weight392.461
Purity98.00%
Density1.3±0.1 g/cm3
Boiling Point568.2±50.0 °C at 760 mmHg
Melting Point235-237°C
AppearanceWhite to off-white crystalline powder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 378-44-9 |
| Catalog No. | 2A-9021606 |
| Chinese Name | 倍他米松 |
| Synonyms | 16β-Methyl-1,4-pregnadiene-9α-fluoro-11β,17α,21-triol-3,20-dione; Bifas; Betasolon; Betadexamethasone; Celestene; Flubenisolone; Visubeta; 9A-FLUORO-16β-METHYLPREDNISOLONE; 9α-Fluoro-11β,17α,21-trihydroxy-16β-methyl-1,4-pregnadiene-3,20-dione; b-Methasone alcohol; Bebate; EINECS 206-825-4; 16b-Methyl-9a-fluoroprednisolone; Celestone; betamethazone; (11b,16b)-9-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione; 9α-Fluoro-16β-methylprednisolone; Betametasona [INN-Spanish]; Betnelan; b-Methasone; β-Methasone; Betametasone [DCIT]; DERMABET; Pertene; β-Methasone alcohol; MFCD00062969; Betsolan; (11β,16β)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione; 4-08-00-03501 (Beilstein Handbook Reference); Diprolene |
| Molecular Formula | C22H29FO5 |
| Molecular Weight | 392.461 |
| Purity | 98.00 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 568.2±50.0 °C at 760 mmHg |
| Melting Point | 235-237°C |
| Appearance | White to off-white crystalline powder |
| Storage Condition | Ventilated low-temperature drying |
| Application | Betamethasone is a glucocorticoid steroid with anti-inflammatory and immunosuppressive activities. |
| HTC | 2937229000 |
| SMILES | CC1CC2C3CCC4=CC(=O)C=CC4(C)C3(F)C(O)CC2(C)C1(O)C(=O)CO |
| InChI | InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,17-,19-,20-,21-,22-/m0/s1 |
| InChI Key | UREBDLICKHMUKA-DVTGEIKXSA-N |
| MSDS | msds/21606_1_378_44_9.pdf |
| Bioactivity | Betamethasone is a glucocorticoid steroid with anti-inflammatory and immunosuppressive properties.Target: Glucocorticoid ReceptorBetamethasone is a potent glucocorticoid steroid with anti-inflammatory and immunosuppressive properties. Unlike other drugs with these effects, betamethasone does not cause water retention. The median (range) IC50 value for betamethasone butyrate propionate evaluated in the streptococcal pyrogenic enterotoxin A-stimulated peripheral-blood mononuclear cells was 291.6 (0.001-1171.5) ng/ml, which was significantly higher than the value 0.072 (0.01-222.5) ng/ml found in concanavalin A-stimulated peripheral-blood mononuclear cells (P=0.0245) [1]. Children exposed prenatally to betamethasone (n = 121) did not differ in systolic or diastolic blood pressure from children exposed to placebo (n = 102) (mean difference: systolic: -1.6 mm Hg; 95% confidence interval: -4.1 to 0.8 mm Hg; diastolic: -0.3 mm Hg; 95% confidence interval: -2.5 to 1.8 mm Hg) [2]. Intra-articular corticosteroid injection of 6 mg of betamethasone acetate/betamethasone sodium phosphate at the knee joint was not significantly associated with SAI at the time points tested [3].Clinical indications: Dermatitis; Discoid lupus erythematosus; Eczema; Lichen; Prurigo; PsoriasisToxicity: Symptoms of overdose include burning, itching, irritation, dryness, folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of the skin, secondary infection, skin atrophy, striae, and miliaria. Related Catalog Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor Research Areas >> Inflammation/Immunology References [1]. Arai, K., et al., Comparative study of the effects of betamethasone butyrate propionate, vitamin D3 derivatives, and cyclosporine on human lymphocyte-proliferation stimulated with a hemolytic streptococci-derived superantigen. Eur J Pharmacol, 2007. 571(2-3): p. 222-30. [2]. Dalziel, S.R., et al., Blood pressure at 6 years of age after prenatal exposure to betamethasone: follow-up results of a randomized, controlled trial. Pediatrics, 2004. 114(3): p. e373-7. [3]. Habib, G., et al., The effect of intra-articular injection of betamethasone acetate/betamethasone sodium phosphate at the knee joint on the hypothalamic-pituitary-adrenal axis: a case-controlled study. J Investig Med, 2013. 61(7): p. 1104-7. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 568.2±50.0 °C at 760 mmHg Melting Point 235-237°C Molecular Formula C22H29FO5 Molecular Weight 392.461 Flash Point 297.5±30.1 °C Exact Mass 392.199890 PSA 94.83000 LogP 1.87 Vapour Pressure 0.0±3.5 mmHg at 25°C Index of Refraction 1.592 InChIKey UREBDLICKHMUKA-DVTGEIKXSA-N SMILES CC1CC2C3CCC4=CC(=O)C=CC4(C)C3(F)C(O)CC2(C)C1(O)C(=O)CO |
| Use of | Properties Articles116 Name betamethasone Synonym More Synonyms Betamethasone Biological Activity Related Catalog Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor Research Areas >> Inflammation/Immunology References [1]. Arai, K., et al., Comparative study of the effects of betamethasone butyrate propionate, vitamin D3 derivatives, and cyclosporine on human lymphocyte-proliferation stimulated with a hemolytic streptococci-derived superantigen. Eur J Pharmacol, 2007. 571(2-3): p. 222-30. [2]. Dalziel, S.R., et al., Blood pressure at 6 years of age after prenatal exposure to betamethasone: follow-up results of a randomized, controlled trial. Pediatrics, 2004. 114(3): p. e373-7. [3]. Habib, G., et al., The effect of intra-articular injection of betamethasone acetate/betamethasone sodium phosphate at the knee joint on the hypothalamic-pituitary-adrenal axis: a case-controlled study. J Investig Med, 2013. 61(7): p. 1104-7. Chemical & Physical Properties Molecular Formula C22H29FO5 Exact Mass 392.199890 PSA 94.83000 Index of Refraction 1.592 InChIKey UREBDLICKHMUKA-DVTGEIKXSA-N |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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