CAS Number364-62-5
SynonymsPramin; Imperan; MAXOLON; Reglan; Maxeran; EINECS 206-662-9; Plasil; metoclopramide; Eucil; Primperan; metoclopramidum [INN_la]; 4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzenecarboximidic acid; 4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide,Methoxychloroprocainamide; 4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide
Molecular FormulaC14H22ClN3O2
Molecular Weight299.80
Purity98.00%
Density1.2±0.1 g/cm3
Boiling Point454.8±55.0 °C at 760 mmHg
Melting Point146-148°C
EINECS206-662-9
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 364-62-5 |
| Catalog No. | 2A-9021516 |
| Chinese Name | 甲氧氯普胺 |
| Synonyms | Pramin; Imperan; MAXOLON; Reglan; Maxeran; EINECS 206-662-9; Plasil; metoclopramide; Eucil; Primperan; metoclopramidum [INN_la]; 4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzenecarboximidic acid; 4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide,Methoxychloroprocainamide; 4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide |
| Molecular Formula | C14H22ClN3O2 |
| Molecular Weight | 299.80 |
| Purity | 98.00 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 454.8±55.0 °C at 760 mmHg |
| Melting Point | 146-148°C |
| Storage Condition | Warehouse Ventilation Low Temperature Drying |
| Application | Metoclopramide is a dopamine D2 receptor antagonist that can prevent vomiting. |
| EINECS | 206-662-9 |
| HTC | 2924299090 |
| PubChem ID | 329754232 |
| MDL Number | MFCD00211338 |
| SMILES | CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OC |
| InChI | 1S/C14H22ClN3O2/c1-4-18(5-2)7-6-17-14(19)10-8-11(15)12(16)9-13(10)20-3/h8-9H,4-7,16H2,1-3H3,(H,17,19) |
| InChI Key | TTWJBBZEZQICBI-UHFFFAOYSA-N |
| Beilstein/REAXYS | 1884366 |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/21516_1_364_62_5.pdf |
| Bioactivity | Metoclopramide is a dopamine D2 antagonist that is used as an antiemetic.IC50 Value:Target: D2 ReceptorMetoclopramide is a dopamine receptor antagonist which has been used for treatment of a variety of gastrointestinal symptoms over the last thirty years. In various countries, metoclopramide is the antiemetic drug of choice in pregnant women. Findings provide reassurance regarding the safety of metoclopramide for the fetus when the drug is given to women to relieve nausea and vomiting during pregnancy. Evidence also supports its use for gastroparesis (poor stomach emptying) and gastroesophageal reflux disease. It appears to bind to dopamine D2 receptors where it is a receptor antagonist, and is also a mixed 5-HT3 receptor antagonist/ 5-HT4 receptor agonist. Related Catalog Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Endocrinology References [1]. Navari RM, Nagy CK, Gray SE. The use of olanzapine versus metoclopramide for the treatment of breakthrough chemotherapy-induced nausea and vomiting in patients receiving highly emetogenic chemotherapy. Support Care Cancer. 2013 Jan 12. [2]. Gutiérrez-Hermosillo H, Díaz de León-González E, Beltrán Santiago D et al. Metoclopramide as a risk factor for postprandial hyperglycemia in type 2 diabetes. Nutr Hosp. 2012 Jul-Aug;27(4):1267-71. [3]. Ilan Matok, Sc.Pharm., Rafael Gorodischer, et al. The Safety of Metoclopramide Use in the First Trimester of Pregnancy. N Engl J Med 2009; 360:2528-2535. [4]. DN Bateman, C Kahn, K Mashiter, DS Davies. Pharmacokinetic and concentration-effect studies with intravenous metoclopramide. British Journal of Clinical Pharmacology.1978,6(5): 401-407 Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 454.8±55.0 °C at 760 mmHg Melting Point 146-148°C Molecular Formula C14H22ClN3O2 Molecular Weight 299.80 Flash Point 228.9±31.5 °C PSA 67.59000 LogP 3.10 Vapour Pressure 0.0±1.2 mmHg at 25°C Index of Refraction 1.545 InChIKey TTWJBBZEZQICBI-UHFFFAOYSA-N SMILES CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OC |
| Use of | Metoclopramide is a dopamine D2 antagonist that is used as an antiemetic.IC50 Value:Target: D2 ReceptorMetoclopramide is a dopamine receptor antagonist which has been used for treatment of a variety of gastrointestinal symptoms over the last thirty years. In various countries, metoclopramide is the antiemetic drug of choice in pregnant women. Findings provide reassurance regarding the safety of metoclopramide for the fetus when the drug is given to women to relieve nausea and vomiting during pregnancy. Evidence also supports its use for gastroparesis (poor stomach emptying) and gastroesophageal reflux disease. It appears to bind to dopamine D2 receptors where it is a receptor antagonist, and is also a mixed 5-HT3 receptor antagonist/ 5-HT4 receptor agonist. Properties Articles63 Name metoclopramide Synonym More Synonyms metoclopramide Biological Activity Description Metoclopramide is a dopamine D2 antagonist that is used as an antiemetic.IC50 Value:Target: D2 ReceptorMetoclopramide is a dopamine receptor antagonist which has been used for treatment of a variety of gastrointestinal symptoms over the last thirty years. In various countries, metoclopramide is the antiemetic drug of choice in pregnant women. Findings provide reassurance regarding the safety of metoclopramide for the fetus when the drug is given to women to relieve nausea and vomiting during pregnancy. Evidence also supports its use for gastroparesis (poor stomach emptying) and gastroesophageal reflux disease. It appears to bind to dopamine D2 receptors where it is a receptor antagonist, and is also a mixed 5-HT3 receptor antagonist/ 5-HT4 receptor agonist. Related Catalog Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Endocrinology References [1]. Navari RM, Nagy CK, Gray SE. The use of olanzapine versus metoclopramide for the treatment of breakthrough chemotherapy-induced nausea and vomiting in patients receiving highly emetogenic chemotherapy. Support Care Cancer. 2013 Jan 12. [2]. Gutiérrez-Hermosillo H, Díaz de León-González E, Beltrán Santiago D et al. Metoclopramide as a risk factor for postprandial hyperglycemia in type 2 diabetes. Nutr Hosp. 2012 Jul-Aug;27(4):1267-71. [3]. Ilan Matok, Sc.Pharm., Rafael Gorodischer, et al. The Safety of Metoclopramide Use in the First Trimester of Pregnancy. N Engl J Med 2009; 360:2528-2535. [4]. DN Bateman, C Kahn, K Mashiter, DS Davies. Pharmacokinetic and concentration-effect studies with intravenous metoclopramide. British Journal of Clinical Pharmacology.1978,6(5): 401-407 Chemical & Physical Properties PSA 67.59000 Index of Refraction 1.545 InChIKey TTWJBBZEZQICBI-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified Metoclopramide Modification Number: 4 |
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