CAS Number154-21-2
SynonymsLincolnensin Hydrochloride; Lincomycin,(2S-cis)-Isomer; UNII-BOD072YW0F; Lincomycin hydrochloride; Lincomycin (USAN/INN); LINCOMYCIN HCL; EINECS 205-824-6; C18H34N2O6S
Molecular FormulaC18H34O6N2S1
Molecular Weight406.54
Purity98.00%
Density1.16
Boiling Point771.9±70.0 °C
Melting Point261-263°C
AppearanceWhite crystalline solid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 154-21-2 |
| Catalog No. | 2A-9021035 |
| Chinese Name | 林可霉素 |
| Synonyms | Lincolnensin Hydrochloride; Lincomycin,(2S-cis)-Isomer; UNII-BOD072YW0F; Lincomycin hydrochloride; Lincomycin (USAN/INN); LINCOMYCIN HCL; EINECS 205-824-6; C18H34N2O6S |
| Molecular Formula | C18H34O6N2S1 |
| Molecular Weight | 406.54 |
| Purity | 98.00 |
| Density | 1.16 |
| Boiling Point | 771.9±70.0 °C |
| Melting Point | 261-263°C |
| Appearance | White crystalline solid |
| Water Solubility | DMSO: >5 mg/mL at 60 °C |
| Storage Condition | 2-8°C |
| Application | Lincomycin is a lincosamide antibiotic and an antibacterial agent used in the study of Gram-positive bacterial infections [1]. |
| HTC | 2941904000 |
| MDL Number | MFCD00135816 |
| SMILES | CCCC1CC(C(=O)NC(C(C)O)C2OC(SC)C(O)C(O)C2O)N(C)C1 |
| InChI | InChI=1S/C18H34N2O6S.ClH.H2O/c1-5-6-10-7-11(20(3)8-10)17(25)19-12(9(2)21)16-14(23)13(22)15(24)18(26-16)27-4;;/h9-16,18,21-24H,5-8H2,1-4H3,(H,19,25);1H;1H2/t9-,10-,11+,12-,13+,14-,15-,16-,18-;;/m1../s1 |
| InChI Key | OJMMVQQUTAEWLP-KIDUDLJLSA-N |
| MSDS | msds/21035_1_154_21_2.pdf |
| Use of | Lincomycin, a lincosamide antibiotic, is an antimicrobial agent used for the research of Gram-positive bacteria infections[1]. Properties Name lincomycin Synonym More Synonyms Lincomycin Biological Activity Description Lincomycin, a lincosamide antibiotic, is an antimicrobial agent used for the research of Gram-positive bacteria infections[1]. Related Catalog Research Areas >> Infection References [1]. Sasaki E, e al. Construction of the octose 8-phosphate intermediate in lincomycin A biosynthesis: characterization of the reactions catalyzed by LmbR and LmbN. J Am Chem Soc. 2012;134(42):17432-17435. Chemical & Physical Properties Molecular Formula C18H34N2O6S PSA 147.79000 LogP 0.27380 Index of Refraction 1.6510 (estimate) InChIKey OJMMVQQUTAEWLP-KIDUDLJLSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : D-erythro-D-Galacto-octopyranoside, methyl-6,8-dideoxy-6-(1-methyl-4-propyl-L-2- pyrrolidinecarboxamido)-1-thio-, trans-alpha- CAS REGISTRY NUMBER : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C18-H34-N2-O6-S MOLECULAR WEIGHT : WISWESSER LINE NOTATION : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978 Volume(issue)/page/year: 1,186,1978 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Brain and Coverings - recordings from specific areas of CNS Blood - other changes REFERENCE : ANKHEW Antibiotiki i Khimioterapiya. Antibiotics and Chemotherapy. (V/O Me zhdunarodnaya Kniga, 113095 Moskow, USSR) V.33- 1988- Volume(issue)/page/year: 35(2),40,1990 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,185,1971 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Brain and Coverings - recordings from specific areas of CNS Blood - other changes REFERENCE : ANKHEW Antibiotiki i Khimioterapiya. Antibiotics and Chemotherapy. (V/O Me zhdunarodnaya Kniga, 113095 Moskow, USSR) V.33- 1988- Volume(issue)/page/year: 35(2),40,1990 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : AACHAX Antimicrobial Agents and Chemotherapy (1961-70). (Ann Arbor, MI) 1961-70. For publisher information, see AMACCQ. Volume(issue)/page/year: -, 554,1962 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : RMVEAG Recueil de Medecine Veterinaire. (Masson Pub. USA, Inc., Year Book Medical Pub., 35 E. Wacker Dr., Chicago IL 60601) V.1- 1824- Volume(issue)/page/year: 156,915,1980 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : TOXIC EFFECTS : Brain and Coverings - recordings from specific areas of CNS Blood - other changes REFERENCE : ANKHEW Antibiotiki i Khimioterapiya. Antibiotics and Chemotherapy. (V/O Me zhdunarodnaya Kniga, 113095 Moskow, USSR) V.33- 1988- Volume(issue)/page/year: 35(2),40,1990 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3678 No. of Facilities: 147 (estimated) No. of Industries: 2 No. of Occupations: 4 No. of Employees: 1414 (estimated) No. of Female Employees: 161 (estimated) Safety Information Hazard Codes Xi RTECS DV2037500 HS Code 2941904000 Precursor & DownStream Precursor 0 DownStream 3 CAS#:13380-36-4 (trans)-4-Propy... CAS#:14810-93-6 Methyl 6-amino-... CAS#:13380-37-5 (2S,4R)-1-methy... |
| Transport Info | Product Name: Lincomycin |
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