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Hydrocortisone sodium succinate structure, CAS 125-04-2

Hydrocortisone sodium succinate

CAS Number125-04-2

SynonymsSodium 4-{[(11β)-11,17-dihydroxy-3,20-dioxopregn-4-en-21-yl]oxy}-4-oxobutanoate; Solu-Glyc; Butanedioic acid, mono[(11β)-11,17-dihydroxy-3,20-dioxopregn-4-en-21-yl] ester, sodium salt (1:1); Hydrocortisone hemisuccinate sodium salt; Intracort; Hydrocortisone sodium succinate; MFCD00069472; (11b)-21-(3-Carboxy-1-oxopropoxy)-11,17-dihydroxypregn-4-ene-3,20-dione Monosodium Salt; Saxizon; EINECS 204-725-5; Buccalsone; butanedioic acid, mono[(11β)-11,17-dihydroxy-3,20-dioxopregn-4-en-21-yl] ester, monosodium salt; Hydrocortisone 21-sodium succinate; Corlan; Nordicort; Sodium 17-hydroxycorticosterone 21-succinate

Molecular FormulaC25H33NaO8

Molecular Weight484.51

Purity≥90 (HPLC)%

Density

Boiling Point685.5ºC at 760mmHg

Melting Point

Flash Point

Appearancepowder

EINECS204-725-5

MSDSChineseEnglish

Symbol

Signal Word

Cat. No.: 2A-9020541 Purity: ≥90 (HPLC)%
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Quality Control of [ 125-04-2 ] Purity: ≥90 (HPLC)% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number125-04-2
Catalog No.2A-9020541
Chinese Name氢化可的松琥珀酸钠
SynonymsSodium 4-{[(11β)-11,17-dihydroxy-3,20-dioxopregn-4-en-21-yl]oxy}-4-oxobutanoate; Solu-Glyc; Butanedioic acid, mono[(11β)-11,17-dihydroxy-3,20-dioxopregn-4-en-21-yl] ester, sodium salt (1:1); Hydrocortisone hemisuccinate sodium salt; Intracort; Hydrocortisone sodium succinate; MFCD00069472; (11b)-21-(3-Carboxy-1-oxopropoxy)-11,17-dihydroxypregn-4-ene-3,20-dione Monosodium Salt; Saxizon; EINECS 204-725-5; Buccalsone; butanedioic acid, mono[(11β)-11,17-dihydroxy-3,20-dioxopregn-4-en-21-yl] ester, monosodium salt; Hydrocortisone 21-sodium succinate; Corlan; Nordicort; Sodium 17-hydroxycorticosterone 21-succinate
Molecular FormulaC25H33NaO8
Molecular Weight484.51
Purity≥90 (HPLC)
Boiling Point685.5ºC at 760mmHg
Appearancepowder
Water SolubilityH2O: 50 mg/mL
Storage Condition−20℃。
ApplicationHydrocortisone hemisuccinate sodium is an orally active physiological glucocorticoid. Hydrocortisone hemisuccinate sodium inhibits the biological activities of IL-6 and IL-3 with IC50 values ​​of 6.7
EINECS204-725-5
PubChem ID24278463
MDL NumberMFCD00069472
SMILESO=C1CC[C@@]2(C)C(CC[C@]3([H])[C@]2([H])[C@@H](O)C[C@@]4(C)[C@@]3([H])CC[C@]4(O)C(COC(CCC([O-])=O)=O)=O)=C1.[Na+]
InChI1S/C25H34O8.Na/c1-23-9-7-15(26)11-14(23)3-4-16-17-8-10-25(32,24(17,2)12-18(27)22(16)23)19(28)13-33-21(31)6-5-20(29)30;/h11,16-18,22,27,32H,3-10,12-13H2,1-2H3,(H,29,30);/q;+1/p-1/t16-,17-,18-,22+,23-,24-,25-;/m0./s1
InChI KeyHHZQLQREDATOBM-CODXZCKSSA-M
NACRES CodeNA.77
UNSPSC12352209
MSDSmsds/20541_1_125_04_2.pdf
BioactivityHydrocortisone hemisuccinate sodium is an orally active physiological glucocorticoid. Hydrocortisone hemisuccinate sodium inhibits proinflammatory cytokine activity, with IC50s of 6.7 and 21.4 μM for IL-6 and IL-3, respectively. Hydrocortisone hemisuccinate sodium can be used for the research of ulcerative colitis (UC)[1]. Related Catalog Research Areas >> Metabolic Disease Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor In Vitro Hydrocortisone hemisuccinate sodium inhibits IL-6 and IL-3 bioactivity, with IC50s of 6.7 and 21.4 μM, respectively, and shows no cytotoxic effects on IL-6-independent MH60 cells[3]. Hydrocortisone hemisuccinate sodium (0.12-60 μM; 72 h) inhibits phytohemagglutinin (PHA) response in peripheral lymphocytes (PBL) and T-lymphocytes cultures[3]. In Vivo Hydrocortisone hemisuccinate sodium (30 mg/kg; p.o. twice daily for 5 d) reduces the weight loss and increases the food intake in mice[2]. Animal Model: Male Sprague-Dawley rats (200-220 g, 10-11 weeks) are induced colitis[2] Dosage: 30 mg/kg Administration: P.o. twice daily for 5 days Result: Significantly decreased the disease activity index (DAI) scores and myeloperoxidase (MPO) activity compared to the 2, 4, 6-trinitrobenzenesulfonic acid (TNBS) group. Increased the body weight. References [1]. Kang BS, et, al. Inhibitory effects of anti-inflammatory drugs on interleukin-6 bioactivity. Biol Pharm Bull. 2001 Jun;24(6):701-3. [2]. You YC, et, al. In vitro and in vivo application of pH-sensitive colon-targeting polysaccharide hydrogel used for ulcerative colitis therapy. Carbohydr Polym. 2015 Oct 5;130:243-53. [3]. Langhoff E, et, al. The immunosuppressive potency in vitro of physiological and synthetic steroids on lymphocyte cultures. Int J Immunopharmacol. 1987;9(4):469-73. Chemical & Physical Properties Boiling Point 685.5ºC at 760mmHg Molecular Formula C25H33NaO8 Molecular Weight 484.51 Flash Point 231.1ºC Exact Mass 484.207306 PSA 141.03000 LogP 0.86260 Appearance of Characters powder Vapour Pressure 9.36E-22mmHg at 25°C InChIKey LGKJVUKNTHOZJH-CODXZCKSSA-N SMILES CC12CCC(=O)C=C1CCC1C2C(O)CC2(C)C1CCC2(O)C(=O)COC(=O)CCC(=O)O.[Na] Storage condition −20°C Water Solubility H2O: 50 mg/mL
Use ofHydrocortisone hemisuccinate sodium is an orally active physiological glucocorticoid. Hydrocortisone hemisuccinate sodium inhibits proinflammatory cytokine activity, with IC50s of 6.7 and 21.4 μM for IL-6 and IL-3, respectively. Hydrocortisone hemisuccinate sodium can be used for the research of ulcerative colitis (UC)[1]. Properties Articles27 Name Hydrocortisone Hemisuccinate Sodium Salt Synonym More Synonyms Corlan Biological Activity Description Hydrocortisone hemisuccinate sodium is an orally active physiological glucocorticoid. Hydrocortisone hemisuccinate sodium inhibits proinflammatory cytokine activity, with IC50s of 6.7 and 21.4 μM for IL-6 and IL-3, respectively. Hydrocortisone hemisuccinate sodium can be used for the research of ulcerative colitis (UC)[1]. Related Catalog Research Areas >> Metabolic Disease Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor References [1]. Kang BS, et, al. Inhibitory effects of anti-inflammatory drugs on interleukin-6 bioactivity. Biol Pharm Bull. 2001 Jun;24(6):701-3. [2]. You YC, et, al. In vitro and in vivo application of pH-sensitive colon-targeting polysaccharide hydrogel used for ulcerative colitis therapy. Carbohydr Polym. 2015 Oct 5;130:243-53. [3]. Langhoff E, et, al. The immunosuppressive potency in vitro of physiological and synthetic steroids on lymphocyte cultures. Int J Immunopharmacol. 1987;9(4):469-73. Chemical & Physical Properties Molecular Formula C25H33NaO8 Exact Mass 484.207306 PSA 141.03000 LogP 0.86260 Appearance of Characters powder InChIKey LGKJVUKNTHOZJH-CODXZCKSSA-N
Transport InfoProduct Name: Hydrocortisone Sodium Succinate
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