CAS Number124-94-7
SynonymsAristocort; Cinolone; EINECS 204-718-7; D1-9a-Fluoro-16a-hydroxyhydrocortisone; MFCD00010477; Triamcinlon; 9α-Fluoro-16α-hydroxyprednisolone; 9a-Fluoro-16a-hydroxyprednisolone; D1-16a-Hydroxy-9a-fluorohydrocortisone; 16a-Hydroxy-9a-fluoroprednisolone; Triamcinolone; (11β,16α)-9-Fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione; Kenalog
Molecular FormulaC21H27FO6
Molecular Weight532.64
Purity99.00%
Density1.4±0.1 g/cm3
Boiling Point587.5±50.0 °C at 760 mmHg
Melting Point262-263 °C(lit.)
AppearanceWhite to off-white crystalline powder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 124-94-7 |
| Catalog No. | 2A-9020539 |
| Chinese Name | 曲安西龙 |
| Synonyms | Aristocort; Cinolone; EINECS 204-718-7; D1-9a-Fluoro-16a-hydroxyhydrocortisone; MFCD00010477; Triamcinlon; 9α-Fluoro-16α-hydroxyprednisolone; 9a-Fluoro-16a-hydroxyprednisolone; D1-16a-Hydroxy-9a-fluorohydrocortisone; 16a-Hydroxy-9a-fluoroprednisolone; Triamcinolone; (11β,16α)-9-Fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione; Kenalog |
| Molecular Formula | C21H27FO6 |
| Molecular Weight | 532.64 |
| Purity | 99.00 |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 587.5±50.0 °C at 760 mmHg |
| Melting Point | 262-263 °C(lit.) |
| Appearance | White to off-white crystalline powder |
| Storage Condition | Storage: sealed at room temperature |
| Application | Triamcinolone is a synthetic, long-acting glucocorticoid. |
| HTC | 2937229000 |
| SMILES | F[C@@]21[C@H]([C@H]4[C@@]([C@@]5(OC(O[C@@H]5C4)(C)C)C(=O)COC(=O)CC(C)(C)C)(C[C@@H]2O)C)CCC3=CC(=O)C=C[C@@]31C |
| InChI | 1S/C30H41FO7/c1-25(2,3)15-24(35)36-16-22(34)30-23(37-26(4,5)38-30)13-20-19-9-8-17-12-18(32)10-11-27(17,6)29(19,31)21(33)14-28(20,30)7/h10-12,19-21,23,33H,8-9,13-16H2,1-7H3/t19-,20-,21-,23+,27-,28-,29-,30+/m0/s1 |
| InChI Key | TZIZWYVVGLXXFV-FLRHRWPCSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/20539_1_124_94_7.pdf |
| Bioactivity | Triamcinolone is a long-acting synthetic corticosteroid.Target: Glucocorticoid ReceptorDimethyl fumarate is an anti-inflammatory. It is indicated for multiple sclerosis patients with relapsing forms and is also being investigated for the treatment of psoriasis. The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MMF up-regulates the Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway that is activated in response to oxidative stress [1]. The mean duration of follow-up was 40 months. The rate of decline in the FEV1 after bronchodilator use was similar in the 559 participants in the triamcinolone group and the 557 participants in the placebo group (44.2±2.9 vs. 47.0±3.0 ml per year, P= 0.50). Members of the triamcinolone group had fewer respiratory symptoms during the course of the study (21.1 per 100 person-years vs. 28.2 per 100 person-years, P=0.005) and had fewer visits to a physician because of a respiratory illness (1.2 per 100 person-years vs. 2.1 per 100 person-years, P=0.03). Those taking triamcinolone also had lower airway reactivity in response to methacholine challenge at 9 months and 33 months (P=0.02 for both comparisons) [2]. Related Catalog Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor Research Areas >> Inflammation/Immunology References [1]. http://www.drugbank.ca/drugs/DB08908#targets [2]. Lung Health Study Research, G., Effect of inhaled triamcinolone on the decline in pulmonary function in chronic obstructive pulmonary disease. N Engl J Med, 2000. 343(26): p. 1902-9. Chemical & Physical Properties Density 1.4±0.1 g/cm3 Boiling Point 587.5±50.0 °C at 760 mmHg Melting Point 262-263 °C(lit.) Molecular Formula C21H27FO6 Molecular Weight 394.434 Flash Point 309.1±30.1 °C Exact Mass 394.179169 PSA 115.06000 LogP 0.83 Vapour Pressure 0.0±3.7 mmHg at 25°C Index of Refraction 1.618 InChIKey GFNANZIMVAIWHM-OBYCQNJPSA-N SMILES CC12C=CC(=O)C=C1CCC1C3CC(O)C(O)(C(=O)CO)C3(C)CC(O)C12F Storage condition 2~8°C |
| Use of | Properties Articles95 Name triamcinolone Synonym More Synonyms Triamcinolone Biological Activity Related Catalog Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor Research Areas >> Inflammation/Immunology References [1]. http://www.drugbank.ca/drugs/DB08908#targets [2]. Lung Health Study Research, G., Effect of inhaled triamcinolone on the decline in pulmonary function in chronic obstructive pulmonary disease. N Engl J Med, 2000. 343(26): p. 1902-9. Chemical & Physical Properties Molecular Formula C21H27FO6 Exact Mass 394.179169 PSA 115.06000 Index of Refraction 1.618 InChIKey GFNANZIMVAIWHM-OBYCQNJPSA-N |
| Transport Info | Product Name: Qu'anxilong |
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