CAS Number549-18-8
SynonymsAmitriptyline Hydrochloride; 3-(5,6-dihydrodibenzo[2,1-b:2',1'-f][7]annulen-11-ylidene)-N,N-dimethylpropan-1-amine,hydrochloride; 3-(10,11-Dihydro-5H-dibenzo[a,d][7]annulen-5-yliden)-N,N-dimethylpropan-1-aminhydrochlorid; 3-(10,11-Dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethylpropan-1-amine hydrochloride (1:1); EINECS 208-964-6; 1-propanamine, 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-, hydrochloride; MFCD00012537; Amitriptyline HCl; 3-(10,11-dihydro-5H-dibenzo[a,d][7]annulén-5-ylidène)-N,N-diméthylpropan-1-amine chlorhydrate; 3-(10,11-Dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethyl-1-propanamine hydrochloride (1:1); 3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethylpropan-1-amine hydrochloride; 5-(3-Dimethylaminopropylidene)di
Molecular FormulaC20H24ClN
Molecular Weight313.86
Purity≥98 (TLC)%
Density1.076g/cm3
Boiling Point398.2ºC at 760 mmHg
Melting Point196-197°C
Appearancepowder
EINECS208-964-6
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 549-18-8 |
| Catalog No. | 2A-9022819 |
| Chinese Name | 盐酸阿米替林 |
| Synonyms | Amitriptyline Hydrochloride; 3-(5,6-dihydrodibenzo[2,1-b:2',1'-f][7]annulen-11-ylidene)-N,N-dimethylpropan-1-amine,hydrochloride; 3-(10,11-Dihydro-5H-dibenzo[a,d][7]annulen-5-yliden)-N,N-dimethylpropan-1-aminhydrochlorid; 3-(10,11-Dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethylpropan-1-amine hydrochloride (1:1); EINECS 208-964-6; 1-propanamine, 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-, hydrochloride; MFCD00012537; Amitriptyline HCl; 3-(10,11-dihydro-5H-dibenzo[a,d][7]annulén-5-ylidène)-N,N-diméthylpropan-1-amine chlorhydrate; 3-(10,11-Dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethyl-1-propanamine hydrochloride (1:1); 3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethylpropan-1-amine hydrochloride; 5-(3-Dimethylaminopropylidene)di |
| Molecular Formula | C20H24ClN |
| Molecular Weight | 313.86 |
| Purity | ≥98 (TLC) |
| Density | 1.076g/cm3 |
| Boiling Point | 398.2ºC at 760 mmHg |
| Melting Point | 196-197°C |
| Appearance | powder |
| Water Solubility | H2O: soluble |
| Storage Condition | 2-8°C |
| Packaging | III |
| Application | Amitriptyline hydrochloride is a tricyclic antidepressant (TCA). |
| EINECS | 208-964-6 |
| PubChem ID | 24278073 |
| MDL Number | MFCD00012537 |
| SMILES | Cl[H].CN(C)CC\C=C1\c2ccccc2CCc3ccccc13 |
| InChI | 1S/C20H23N.ClH/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20;/h3-6,8-12H,7,13-15H2,1-2H3;1H |
| InChI Key | KFYRPLNVJVHZGT-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | 6.1(b) |
| MSDS | msds/22819_1_549_18_8.pdf |
| Bioactivity | Amitriptyline Hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA).Target: OthersAmitriptyline acts primarily as a serotonin-norepinephrine reuptake inhibitor, with strong actions on the serotonin transporter and moderate effects on the norepinephrine transporter. It has negligible influence on the dopamine transporter and therefore does not affect dopamine reuptake, being nearly 1,000 times weaker on it than on serotonin [1]. Amitriptyline additionally functions as a 5-HT2A, 5-HT2C, 5-HT3, 5-HT6, 5-HT7, α1-adrenergic, H1, H2, and mACh receptorantagonist, and σ1 receptor agonist. It has also been shown to be a relatively weak NMDA receptor negative allosteric modulator at the same binding site as phencyclidine. Amitriptyline inhibits sodium channels, L-type calcium channels, and Kv1.1, Kv7.2, and Kv7.3 voltage-gated potassium channels, and therefore acts as a sodium, calcium, and potassium channel blocker as well [2]. Recently, amitriptyline has been demonstrated to act as an agonist of the TrkA and TrkB receptors. It promotes the heterodimerization of these proteins in the absence of NGF and has potent neurotrophic activity both in-vivo and in-vitro in mouse models [3]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Neurological Disease References [1]. Tatsumi, M., et al., Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol, 1997. 340(2-3): p. 249-58. [2]. http://en.wikipedia.org/wiki/Amitriptyline [3]. Jang, S.W., et al., Amitriptyline is a TrkA and TrkB receptor agonist that promotes TrkA/TrkB heterodimerization and has potent neurotrophic activity. Chem Biol, 2009. 16(6): p. 644-56. Chemical & Physical Properties Density 1.076g/cm3 Boiling Point 398.2ºC at 760 mmHg Melting Point 196-197°C Molecular Formula C20H24ClN Molecular Weight 313.864 Flash Point 11 °C Exact Mass 313.159729 PSA 3.24000 LogP 4.97060 InChIKey KFYRPLNVJVHZGT-UHFFFAOYSA-N SMILES CN(C)CCC=C1c2ccccc2CCc2ccccc21.Cl Storage condition 2-8°C Water Solubility H2O: soluble |
| Use of | Properties Articles61 Name Amitriptyline hydrochloride Synonym More Synonyms Amitriptyline Hydrochloride Biological Activity Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Neurological Disease References [1]. Tatsumi, M., et al., Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol, 1997. 340(2-3): p. 249-58. [2]. http://en.wikipedia.org/wiki/Amitriptyline [3]. Jang, S.W., et al., Amitriptyline is a TrkA and TrkB receptor agonist that promotes TrkA/TrkB heterodimerization and has potent neurotrophic activity. Chem Biol, 2009. 16(6): p. 644-56. Chemical & Physical Properties Exact Mass 313.159729 PSA 3.24000 LogP 4.97060 InChIKey KFYRPLNVJVHZGT-UHFFFAOYSA-N Water Solubility H2O: soluble |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Dangerous Regulations for land transport: 2811 International Dangerous Regulations for sea transport: 2811 International Dangerous Regulations for air transport: 2811 14.2 United Nations shipping name European Land Transport Dangerous Regulations: TOXIC SOLID, ORGANIC, N.O.S. (Amitriptyline hydrochloride) IMDG: TOXIC SOLID, ORGANIC, N.O.S. (Amitriptyline hydrochloride) International air transport hazard regulations: Toxic solid, organic, n.o.s. (Amitriptyline hydrochloride) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Dangerous Regulations: Yes International Maritime Transport Dangerous Regulations International Air Transport Dangerous Regulations: No Marine Pollutants (Yes/No): Yes 14.6 Special reminder to users No data available |
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